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Zebrafish As an Animal Model for Cancer Research

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Zebrafish has emerged as a veritable animal tool used for modeling human cancers. It is currently used to study the development of tumors in several organs in relation to human cancers. This model studies the similarity in the morphology, histology, physiology, and genetic composition of zebrafish cancer model and human malignancies. This model gives room for cancer therapeutic research, drug design, and modification. With the zebrafish as an animal model for cancer, research tools can have relatively short duration and little amount of drug can be easily tested, easily manipulated, transparent, and highly predictable. It is of note that the zebrafish cancer model provides suitable underlying and unique insights into mechanisms of cancers. It may provide possible cancer chemopreventive actions based on the underlying mechanisms. This chapter compiles the biology of zebrafish and its suitability as an animal model for cancer.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Federal University of Technology, Akure, Nigeria

    Stephen Adeniyi Adefegha & Aderonke Elizabeth Fakayode

  2. Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

    Olorunfemi Raphael Molehin

  3. Department of Animal Health, Federal College of Agriculture, Akure, Nigeria

    Omowunmi Monisola Adefegha

Authors
  1. Stephen Adeniyi Adefegha
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  2. Olorunfemi Raphael Molehin
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  3. Omowunmi Monisola Adefegha
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  4. Aderonke Elizabeth Fakayode
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Editor information

Editors and Affiliations

  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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© 2022 Springer Nature Singapore Pte Ltd.

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Adefegha, S.A., Molehin, O.R., Adefegha, O.M., Fakayode, A.E. (2022). Zebrafish As an Animal Model for Cancer Research. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_9-1

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  • DOI: https://doi.org/10.1007/978-981-19-1282-5_9-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-1282-5

  • Online ISBN: 978-981-19-1282-5

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