Abstract
Mollusca is one of the largest phyla in the animal kingdom that inhabit diverse ecosystems across the planet earth. The innate immunity of mollusk plays a significant role in recognizing and eliminating pathogen as it lacks antibody mediated immunity. Pattern recognition receptors (PRRs) in the cytoplasm of molluscs recognize conserved structures of different pathogen associated molecule patterns (PAMPs) which is vital for pathogen physiology and pathogen fitness. One of the domains in PRRs is lectin which is a carbohydrate binding protein that acts as a defense molecule against pathogens, excludes them out and protects the animal. Mollusc has different types of lectins such as C-type, P-type, F-type, I-type, S-type (Galectins), Ficolins and Chitinase like lectins which have greater applications as therapeutic agent to treat cancer, bacterial, and fungal diseases. Mollusc lectins are involved in host recognition and tissue adhesion and also in drug discovery process. Most of the researchers found that C-type lectins play a key role in immune recognition and defense mechanism.
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Abbreviations
- ADEL:
-
Aplysia dactylomela egg lectin
- AK:
-
Arginine kinase
- C3:
-
Complement component 3
- CGL:
-
Crenomytilus grayanus lectin
- CRD:
-
Carbohydrate recognition domain
- CTL:
-
C-type lectins
- DlFBL:
-
Dicentrarchus labrax fucose binding lectin
- FBG:
-
Fibrinogen like domain
- FREPS:
-
Fibrinogen related proteins
- HddSBL:
-
Haliotis discus discus Sialic acid binding lectin
- Ig:
-
Immunoglobulin
- LPS:
-
Lipopolysaccharide
- LRR:
-
Leucine rich repeat
- LTA:
-
Lipoteichoic acid
- M6P:
-
Mannose-6-phosphate
- MAC:
-
Membrane attack complex
- MAN:
-
Mannan
- MCL:
-
Mytilus californianus lectin
- PAMPs:
-
Pathogen associated molecule patterns
- PEPCK:
-
Phosphoenol pyuruvate carboxy kinase
- PGN:
-
Peptidoglycan
- PRRs:
-
Pattern recognition receptors
- SABL:
-
Sialicacid binding lectins
- SR:
-
Scavenger receptor
- TLRs:
-
Toll like receptors
References
Adhya M, Choi KSA, Yu Y, Cho M (2010) Expression and localization of McSialec, a Sialic acid specific lectin in the marine bivalve Manila clam, Ruditapes philppinarum. J Fish Dis 33(11):889–899. https://doi.org/10.1111/j.1365-2761.2010.01195.x
Allam B, Raftos D (2015) Immune responses to infectious diseases in bivalves. J Invertebr Pathol 131:121–136. https://doi.org/10.1016/j.jip.2015.05.005
Allam S, Allam B, Espinosa EP (2020) Regulation of mucosal lectins in the oyster Crassostrea virginica in response to food availability and environmental factors. J Moll Stud:1–8. https://doi.org/10.1093/mollus/eyaa037
Angata T, Linden ECMBV (2002) I—type lectins. Biochim Biophys Acta 1572:294–316. https://doi.org/10.1016/S0304-4165(02)00316-1
Badariotti F, Kypriotou M, Lelong C, Dubos M, Renard E, Galera P, Favrel P (2006) The phylogenetically conserved molluscan chitinase-like protein 1 (Cg-Clp1), homologue of human HC-gp39, stimulates proliferation and regulates synthesis of extracellular matrix components of mammalian chondrocytes. J Biol Chem 281:29583–29596. https://doi.org/10.1074/jbc.M605687200
Biswas C, Sinha D, Mandal C (2000) Investigation on interaction of Achatinin, a 9-O-acetyl sialic acid binding lectin with lipo polysaccharide in the innate immunity of Achatina fulica snails. Mol Immunol 37:745–754. https://doi.org/10.1016/S0161-5890(00)00096-1
Chikalovetes IV, Chernikov OV, Pirkin MV, Molchanova VI, Litovchenko A, Li W, Lukyanov PA (2015) A lectin with antifungal activity from the mussel Crenotilus grayanus. Fish Shellfish Immunol 42:503–507. https://doi.org/10.1016/j.fsi.2014.11.036
Espinosa RA, Lozano BA (1997) Biochemical properties of hemagglutinins in the mollusc Pomacea flagellate. Biochem Mol Biol Int 43(6):1241–1251. https://doi.org/10.1080/15216549700205071
Espinosa EP, Perrigault MJ, Ward E, Shumway SE, Allam B (2009) Lectins associated with the feeding organs of the oyster Crassostrea virginica can mediate particle selection. Biol Bull 217:130–141. https://doi.org/10.1086/BBLv217n2p130
Fortunato H (2015) Molluscs: tools in environmental and climate research. Am Malacol Bull 33(2):310–324. https://doi.org/10.4003/006.033.0208
GarcÃa-Maldonado E, Cano-Sánchez P, Hernández-Santoyo A (2017) Molecular and functional characterizationof a glycosylated galactose-binding lectin from Mytilus californianus. Fish Shellfish Immunol 66:564–574. https://doi.org/10.1016/j.fsi.2017.05.057
Ghosh S (2017) Sialic acid binding lectins (SABL) from mollusca, a review and insilico study of SABL from Solen grandis and Limax flavus. J Entomol Zool Stud 5(6):1563–1572
Hamid R, Masood A, Wani IH, Rafiq S (2013) Lectins: proteins with diverse applications. J Appl Pharmaceut Sci 3(4):S93–S103. https://doi.org/10.7324/JAPS.2013.34.S18
He X, Zhang Y, Yu F, Yu Z (2011) A novel sialic acid binding lectin with antibacterial activity from the hongkong oyster (Crassostrea hongkongensis). Fish Shellfish Immunol 31:1247–1250. https://doi.org/10.1016/j.fsi.2011.08.021
Hickman CP, Roberts LS, Larson A (2002) Animal diversity, 3rd edn. McGraw-Hill Science, Boston
Huang M, Zhang H, Jiang S, Wang L, Liu R, Yi Q, Song L (2014) An EPD/WSD motifs containing C-type lectin from Argopectens irradians recognizes and binds microbes with broad spectrum. Fish Shellfish Immunol 43:287–293. https://doi.org/10.1016/j.fsi.2014.12.035
Khalaifah HA, Nasser AA (2018) Immune response of molluscs. Intech open book series. https://doi.org/10.5772/intechopen.81778.
Kovalchuk SN, Chikalovetes IV, Chernikov OV, Molchanova VI, Li W, Rasskazov VA, Lukyanov PA (2013) cDNA cloning and structural characterization of a lectin from mussel Crenomytilus grayanus with unique aminoacid sequence and antibacterial activity. Fish Shellfish Immunol 35(4):1320–1324. https://doi.org/10.1016/j.fsi.2013.07.011
Kumar KK, Chandra LP, Sumanthi J, Reddy SG, Shekar CP, Reddy BVR (2015) Biological role of lectins: a review. J Orofac Sci 4(1):20–25. https://doi.org/10.4103/0975-8844.99883
Li C, Yu S, Zhao J, Su X, Li T (2011) Cloning and characterization of a sialic acid binding lectins (SABL) from Manila clam Venerupis philippinarum. Fish Shellfish Immunol 30:1202–1206. https://doi.org/10.1016/j.fsi.2011.02.022
Loh SH, Park JY, Cho EH, Nah SY, Kang YS (2015) Animal lectins: potential receptors for ginseng polysaccharides. J Ginseng Res:1–9. https://doi.org/10.1016/j.jgr.2015.12.006
Mayer AMS, Rodriguez AD, Taglialatela-Scafati O, Fuestani N (2013) Marine pharmacology in 20092011: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar Drugs 11(7):2510–2573. https://doi.org/10.3390/md11072510
Ogawa T, Watanabe M, Naganuma T, Muramoto K (2011) Diversified carbohydrate binding lectins from marine resources. Res J Amino Acids 2011:838914. https://doi.org/10.4061/2011/838914
Pati P, Sahu BK, Panigrahy RC (2015) Marine molluscs as a potential drug cabinet: an overview. Indian J Geo-Mar Sci 44(7):961–970
Santos AFS, Silva MDS, Napoleao TH, Paiva PMG, Corneia MTS, Coelho LCBB (2014) Lectins: function, structure, biological properties and potential applications. Curr Topics Peptide Protein Res 15:41–62
Sharon N, Lis H (2013) Lectins. Lipids carbohydrates membranes and membrane proteins. Elsevier, Amsterdam, pp 701–705. https://doi.org/10.1021/cr940413g
Singh RS, Tiwary AK, Kennedy JT (1999) Lectins: sources, activities and applications. Crit Rev Biotechnol 19(2):145–178. https://doi.org/10.1080/0738-859991229224
Sivasubramanian K, Ravichandran S, Kumaresan M (2011) Preliminary studies for a new antibiotic from the marine mollusk Melomelo (Lightfoot, 1786). Asian Pac J Trop Med 4(4):310–314. https://doi.org/10.1016/S1995-7645(11)60092-8
Srikumaran N, Bragadeeswaran S, Thangaraj S (2011) Screening for antimicrobial activities of marine molluscsThais tissoti (Petit, 1852) and Babylonia spirata (Linnaeus, 1758) against human, fish and biofilm pathogenic microorganisms. Afr J Microbiol Res 5(24):4155–4161
Takahashi KG, Kuroda T, Muroga K (2008) Purification and antibacterial characterization of novel isoform of the Manila clam lectin (MCL-4) from the plasma of the Manila clam Ruditapes philippinarum. Comp Biochem Physiol Pt B:45–52. https://doi.org/10.1016/j.cbpb.2008.01.006
Varrot A, Blanchard B, Imberty A (2011) Lectin binding and its structural basis. In: Carbohydrate recognition: biological problems, methods and applications, 1st edn. Wiley, Hoboken, NJ, pp 329–347. https://doi.org/10.1002/9781118017586.ch13
Wang L, Wang L, Huang M, Zhang H, Song L (2011) The immune role of C- type lectins in molluscs. Int Scholars J 8:241–246
Wang L, Qiu L, Zhou Z, Song L (2013) Research Progress on the mollusc immunity in china. Dev Comp Immunol 39:2–10. https://doi.org/10.1016/j.dci.2012.06.014
Wang L, Yue F, Song X, Song L (2014) Maternal immune transfer in mollusc. Dev Comp Immunol 48:354–359. https://doi.org/10.1016/j.dci.2014.05.010
Wang W, Song X, Wang L, Song L (2018) Pathogen derived carbohydrate recognition in molluscs immune defense. Int J Mol Sci 19:1–20. https://doi.org/10.3390/ijms19030721
Wu B, Mei S, Cui L, Zhao Z, Chen J, Wu T, Li G (2017) Marine lectins DIFBL and HddSBL fused with soluble coxsackie-adenovirus receptor facilitate adenovirus infection in cancer cells but have different effects on cell survival. Mar Drugs 15:1–13. https://doi.org/10.3390/md15030073
Xiang Z, Qu F, Wang F, Li J, Zhang Y, Yu Z (2014) Characteristic and functional analysis of a ficolin-likeprotein from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol 40:514–523. https://doi.org/10.1016/j.fsi.2014.08.006
Yang J, Wang L, Zhang H, Qiu L, Wang H, Song L (2011) C-type lectin in Chlamys farreri (Cf Lec-1) mediating immune recognition and opsonization. PLoS One 6(2):e17089. https://doi.org/10.1371/journal.pone.0017089
Yang J, Wei X, Liu X, Xu J, Yang D, Yang J (2012) Cloning and transcriptional analysis of two sialic acid binding lectins (SABLs) from razor clam Solen grandis. Fish Shellfish Immunol 32:578–585. https://doi.org/10.1016/j.fsi.2012.01.012
Acknowledgments
The authors are thankful to the authorities of Thiagarajar College, Madurai, India for the institutional facilities.
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Chellapackialakshmi, M., Ravi, C. (2022). Investigation on Mollusc Lectins. In: Elumalai, P., Vaseeharan, B., Lakshmi, S. (eds) Aquatic Lectins. Springer, Singapore. https://doi.org/10.1007/978-981-19-0432-5_5
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