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ILC Differentiation from Progenitors in the Bone Marrow

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Innate Lymphoid Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1365))

Abstract

Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.

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Authors and Affiliations

  1. T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA

    Arundhoti Das, Yi Ding & Avinash Bhandoola

  2. Université de Nantes, CNRS, INSERM, CRCINA, Nantes, France

    Christelle Harly

  3. LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France

    Christelle Harly

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  1. Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Xiao-Hong Sun

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Das, A., Harly, C., Ding, Y., Bhandoola, A. (2022). ILC Differentiation from Progenitors in the Bone Marrow. In: Sun, XH. (eds) Innate Lymphoid Cells. Advances in Experimental Medicine and Biology, vol 1365. Springer, Singapore. https://doi.org/10.1007/978-981-16-8387-9_2

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