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Uncommon Types of Gastritis and Gastropathies Including Anti-parietal Cell, GVHD, Reactive and Granulomatous Gastritis

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Interpretation of Endoscopic Biopsy - Gastritis, Gastropathies and Beyond

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Abstract

Besides other autoimmune related gastritis indicated by lymphocytic dominance cell response, anti-parietal cell-related gastritis has different significance both morphologically and clinically. In addition, there are other autoantibody-related conditions like inflammatory bowel disease and graft versus host disease, which show specific morphological changes in gastric biopsies. Stomach is the first organ where many of the substances consumed, produces mucosal injury with specific cellular response. Granulomatous gastritis is a separate entity in itself. Gastropathy is a term coined for gastric mucosal abnormality with minimal inflammatory cell response.

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References

  1. Toh BH, Sentry JW, Alderuccio F. The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis. Immunol Today. 2000;21:348–54.

    CAS  PubMed  Google Scholar 

  2. Faber K. Achylia gastrica mit Anamie. Med Klin. 1909;5:1310–25.

    Google Scholar 

  3. Cabrera de León A, Almeida González D, Almeida AA, et al. Factors associated with parietal cell autoantibodies in the general population. Immunol Lett. 2012;147:63–6.

    PubMed  Google Scholar 

  4. Toh BH, Chan J, Kyaw T, Alderuccio F. Cutting edge issues in autoimmune gastritis. Clin Rev Allergy Immunol. 2012;42:269–78.

    CAS  PubMed  Google Scholar 

  5. Lenti MV, Rugge M, Lahner E, et al. Autoimmune gastritis. Nat Rev Dis Primers. 2020;6:56.

    PubMed  Google Scholar 

  6. El-Zimaity H, Riddell R. Stomach and proximal duodenum: inflammatory and miscellaneous disorders. In: Riddell R, Jain D, editors. Lewin, Weinstein, and Riddell’s gastrointestinal pathology and its clinical implications. Philadelphia, PA: Wolters Kluwer; 2014. p. 635–43.

    Google Scholar 

  7. Hall SN, Appelman HD. Autoimmune gastritis. Arch Pathol Lab Med. 2019;143:1327–31.

    CAS  PubMed  Google Scholar 

  8. Minalyan A, Benhammou JN, Artashesyan A, et al. Autoimmune atrophic gastritis: current perspectives. Clin Exp Gastroenterol. 2017;10:19–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Neumann WL, Coss E, Rugge M, et al. Autoimmune atrophic gastritis—pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol. 2013;10:529–41.

    CAS  PubMed  Google Scholar 

  10. Abdullah BA, Gupta SK, Croffie JM, et al. The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study. J Pediatr Gastroenterol Nutr. 2002;35:636–40.

    PubMed  Google Scholar 

  11. Burke KE, Boumitri C, Ananthakrishnan AN. Modifiable environmental factors in inflammatory bowel disease. Curr Gastroenterol Rep. 2017;19:21.

    PubMed  PubMed Central  Google Scholar 

  12. McHugh JB, Gopal P, Greenson JK. The clinical significance of focally enhanced gastritis in children. Am J Surg Pathol. 2013;37:295–9.

    PubMed  Google Scholar 

  13. Kundhal PS, Stormon MO, Zachos M, et al. Gastric antral biopsy in the differentiation of pediatric colitides. Am J Gastroenterol. 2003;98:557–61.

    CAS  PubMed  Google Scholar 

  14. Putra J, Ornvold K. Focally enhanced gastritis in children with inflammatory bowel disease: a clinicopathological correlation. Correspondence. 2017;49:808–10.

    Google Scholar 

  15. Meining A, Bayerdörffer E, Bästlein E, et al. Focal inflammatory infiltrations in gastric biopsy specimens are suggestive of Crohn’s disease. Scand J Gastroenterol. 1997;32:813–8.

    CAS  PubMed  Google Scholar 

  16. Oberhuber G, Püspök A, Oesterreicher C, et al. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease. Gastroenterology. 1997;112:698–706.

    CAS  PubMed  Google Scholar 

  17. Parente F, Cucino C, Bollani S, et al. Focal gastric inflammatory infiltrates in inflammatory bowel disease: prevalence, immunohistochemical characteristics, and diagnostic role. Am J Gastroenterol. 2000;95:705–11.

    CAS  PubMed  Google Scholar 

  18. Xin W, Greenson JK. The clinical significance of focally enhanced gastritis. Am J Surg Pathol. 2004;28:1347–51.

    PubMed  Google Scholar 

  19. Westerhoff M, Lamps L. Mucosal biopsy after bone marrow transplantation. Surg Pathol Clin. 2017;10:909–30.

    PubMed  Google Scholar 

  20. Lubner MG, Menias CO, Agrons M, et al. Imaging of abdominal and pelvic manifestations of graft-versus-host disease after hematopoietic stem cell transplant. Am J Roentgenol. 2017;209:33–45.

    Google Scholar 

  21. Salomao M, Dorritie K, Mapara MY, et al. Histopathology of graft-vs-host disease of gastrointestinal tract and liver: an update. Am J Clin Pathol. 2016;145:591–603.

    CAS  PubMed  Google Scholar 

  22. Brodoefel H, Bethge W, Vogel M, et al. Early and late-onset acute GvHD following hematopoietic cell transplantation: CT features of gastrointestinal involvement with clinical and pathological correlation. Eur J Radiol. 2010;73:594–600.

    CAS  PubMed  Google Scholar 

  23. Washington K, Jagasia M. Pathology of graft-versus-host disease in the gastrointestinal tract. Hum Pathol. 2009;40:909–17.

    PubMed  Google Scholar 

  24. Malard F, Mohty M. New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. Mediators Inflammation. 2014;2014:701013.

    Google Scholar 

  25. Spencer GD, Shulman HM, Myerson D, et al. Diffuse intestinal ulceration after marrow transplantation: a clinicopathologic study of 13 patients. Hum Pathol. 1986;17:621–33.

    CAS  PubMed  Google Scholar 

  26. Sauer S, Radujkovic A, Hegenbart U, et al. Cytokeratin (CK)-18 and CK18 fragments as sensitive and specific biomarkers of acute hepato-intestinal GVHD: results of a prospective observational study. Blood. 2015;126:3083.

    Google Scholar 

  27. Sauer S, Hüsing J, Hajda J, et al. A prospective study on serum cytokeratin (CK)-18 and CK18 fragments as biomarkers of acute hepato-intestinal GVHD. Leukemia. 2018;32:2685–92.

    CAS  PubMed  Google Scholar 

  28. Shulman HM, Cardona DM, Greenson JK, et al. NIH consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report. Biol Blood Marrow Transplant. 2015;21:589–603.

    PubMed  PubMed Central  Google Scholar 

  29. Jagasia MH, Greinix HT, Arora M, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant. 2015;21:389–401.

    PubMed  Google Scholar 

  30. Lee SJ, Wolff D, Kitko C, et al. Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group Report. Biol Blood Marrow Transplant. 2015;21:984–99.

    PubMed  PubMed Central  Google Scholar 

  31. Peled JU, Hanash AM, Jenq RR. Role of the intestinal mucosa in acute gastrointestinal GVHD. Hematol Am Soc Hematol Educ Prog. 2016;2016:119–27.

    Google Scholar 

  32. Hartley CP, Carrillo-Polanco LF, Rowan DJ, et al. Colonic graft-vs.-host disease in autologous versus allogeneic transplant patients: earlier onset, more apoptosis, and lack of regulatory T-cell attenuation. Mod Pathol. 2018;31:1619–26.

    CAS  PubMed  Google Scholar 

  33. Bensley EH. Alexis St Martin. Can Med Assoc J. 1959;80:907–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Cotton PB, Rosenberg MT, Axon AT, et al. Diagnostic yield of fibre-optic endoscopy in the operated stomach. Br J Surg. 1973;60:629–32.

    CAS  PubMed  Google Scholar 

  35. Krentz K. Gastroscopic and aspiration biopsy findings on the operated stomach. Dtsch Med Wochenschr. 1964;89:664–71.

    CAS  PubMed  Google Scholar 

  36. Lechner HJ, Anton D. The histology of gastric mucosa in B II-stomach. Z Gastroenterol. 1979;17:674–9.

    CAS  PubMed  Google Scholar 

  37. Mosimann F, Sorgi M, Wolverson RL, et al. Bile reflux after duodenal ulcer surgery. A study of 114 asymptomatic and symptomatic patients. Scand J Gastroenterol Suppl. 1984;92:224–6.

    CAS  PubMed  Google Scholar 

  38. Langhans P, Bues M, Bunte H. Morphological changes in the operated stomach under the influence of duodenogastric reflux. Clinical follow-up over 20 years. Scand J Gastroenterol Suppl. 1984;92:145–8.

    CAS  PubMed  Google Scholar 

  39. Langhans P, Heger RA, Stegemann B. The cancer risk in the stomach subjected to nonresecting procedures. An experimental long-term study. Aliment Pharmacol Ther. 2012;36:736–43.

    Google Scholar 

  40. Offerhaus GJ, Stadt J, Huibregtse K, et al. Endoscopic screening for malignancy in the gastric remnant: the clinical significance of dysplasia in gastric mucosa. J Clin Pathol. 1984;37:748–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Dewar P, Dixon MF, Johnston D. Bile reflux and degree of gastritis in patients with gastric ulcer: before and after operation. J Surg Res. 1984;37:277–84.

    CAS  PubMed  Google Scholar 

  42. Dixon MF, O’Connor HJ, Axon AT, et al. Reflux gastritis: distinct histopathological entity? J Clin Pathol. 1986;39:524–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Dixon MF, Genta RM, Yardley JH. Classification and grading of gastritis. The updated Sydney System. International Workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol. 1994;20:1161–81.

    Google Scholar 

  44. Genta RM. Differential diagnosis of reactive gastropathy. Semin Diagn Pathol. 2005;22:273–83.

    PubMed  Google Scholar 

  45. Wyatt JI, Dixon MF. Chronic gastritis—a pathogenesis approach. J Pathol. 1988;40:113–24.

    Google Scholar 

  46. De Nardi F, Riddell RH. Reactive (chemical) gastropathy and gastritis. In: Graham DY, Genta RM, Dixon MF, editors. Gastritis. Philadelphia, PA: Lippincott Williams & Wilkins; 1999. p. 125–47.

    Google Scholar 

  47. Owen D. Gastritis and carditis. Mod Pathol. 2003;16:325–41.

    PubMed  Google Scholar 

  48. Srivastava A. Pathology of non-infective gastritis. Histopathology. 2007;50:15–29.

    CAS  PubMed  Google Scholar 

  49. Ramos S, del Pilar M, Baquero M, et al. Reactive gastropathy: frequency in endoscopic biopsies evaluated at the Universidad Nacional de Colombia. Rev Colomb Gastroenterol. 2011;26:253–60.

    Google Scholar 

  50. Maguilnik WL, Neumann A, Sonnenberg R, et al. Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract. Aliment Pharmacol Ther. 2012;36:736–43.

    CAS  PubMed  Google Scholar 

  51. Nakos A, Kouklakis G, Pitiakoudis M, et al. The histological and immunohistochemical aspects of bile reflux in patients with gastroesophageal reflux disease. Gastroenterol Res Pract. 2011;2011:905872. https://doi.org/10.1155/2011/905872.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Raja J, Meriam S, Meriam N, et al. Granulomatous gastritis: a clinicopathologic analysis of 39 biopsy cases. J Spleen Liver Res. 2018;1:10–5.

    Google Scholar 

  53. Ectors NL, Dixon MF, Geboes KJ, et al. Granulomatous gastritis: a morphological and diagnostic approach. Histopathology. 1993;23:55–61.

    CAS  PubMed  Google Scholar 

  54. Shapiro JL, Goldblum JR, Petras RE. A clinicopathologic study of 42 patients with granulomatous gastritis. Is there really an “idiopathic” granulomatous gastritis? Am J Surg Pathol. 1996;20:462–70.

    CAS  PubMed  Google Scholar 

  55. Maeng L, Lee A, Choi K, et al. Granulomatous gastritis: a clinicopathologic analysis of 18 biopsy cases. Am J Surg Pathol. 2004;28:941–5.

    PubMed  Google Scholar 

  56. Genta RM. Granulomatous gastritis. In: Graham DY, Genta RM, Dixon MF, editors. Gastritis. Philadelphia, PA: Lippincott Williams & Wilkins; 1999.

    Google Scholar 

  57. Amarnath S, Deeb L, Philipose J, et al. A comprehensive review of infectious granulomatous diseases of the gastrointestinal tract. Gastroenterol Res Pract. 2021;2021:8167149. https://doi.org/10.1155/2021/8167149.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Miyamoto M, Yoshihara K, Haruma M, et al. isolated granulomatous gastritis: successfully treated by H pylori eradication: a possible association between gastritis granulomatous and Helicobacter pylori. J Gastroenterol. 2003;38:371–5.

    PubMed  Google Scholar 

  59. Dor-Ben D, Landa E, Delgado S. Granulomatous gastritis and H pylori Infection. Isr Med Assoc J. 2013;15:385–6.

    Google Scholar 

  60. Lauwers GY. Gastritis: beyond Helicobacter pylori. Int J Surg Pathol. 2010;18:28S.

    PubMed  Google Scholar 

  61. Vahid B, Spodik M, Braun KN, et al. Sarcoidosis of gastrointestinal tract: a rare disease. Dig Dis Sci. 2007;52:3316.

    PubMed  Google Scholar 

  62. Masiak A, Zdrojewski Ł, Zdrojewski Z, et al. Gastrointestinal tract involvement in granulomatosis with polyangiitis. Przegl Gastroenterol. 2016;11:270–5.

    Google Scholar 

  63. Zheng Z, Ding J, Li X, et al. Gastric presentation (vasculitis) mimics a gastric cancer as initial symptom in granulomatosis with polyangiitis: a case report and review of the literature. Rheumatol Int. 2015;35:1925–9.

    PubMed  Google Scholar 

  64. Temmesfeld-Wollbrueck B, Heinrichs C, Szalay A, et al. Granulomatous gastritis in Wegener’s disease: differentiation from Crohn’s disease supported by a positive test for antineutrophil antibodies. Gut. 1997;40:550–3.

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Liang WY, Lauwers GY. Granulomatous gastritis. In: Carneiro F, Chaves P, Ensari A, editors. Pathology of the gastrointestinal tract. Encyclopedia of pathology. Cham: Springer; 2017. https://doi.org/10.1007/978-3-319-40560-5_1614.

    Chapter  Google Scholar 

  66. Yan F, Zhou Q, Gao Y, et al. Isolated Langerhans cell histiocytosis of the stomach: a case report and literature review. Int J Clin Exp Pathol. 2018;11:5962–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Lee SJ, Hwang CS, Huh GY, et al. Gastric Langerhans cell histiocytosis: case report and review of the literature. J Pathol Transl Med. 2015;49:421–3.

    PubMed  PubMed Central  Google Scholar 

  68. Leeds JS, McAlindon ME, Lorenz E, et al. Gastric sarcoidosis mimicking irritable bowel syndrome—cause not association? World J Gastroenterol. 2006;12:4754–6.

    PubMed  PubMed Central  Google Scholar 

  69. Bhattarai B, Mandal A, Lamichhane J, et al. A symptomatic gastric sarcoidosis and asymptomatic pulmonary sarcoidosis: a rare manifestation. J Community Hosp Intern Med Perspect. 2019;9:440–2.

    PubMed  PubMed Central  Google Scholar 

  70. Sameh S, Mohamed Salah H, Mohamed G, et al. Gastric sarcoidosis: rare revealing feature of systemic sarcoidosis. Arab J Gastroenterol. 2020;21:62–4.

    PubMed  Google Scholar 

  71. Uzzan M, Ko H, Mehandru S, et al. Gastrointestinal disorders associated with common variable immune deficiency (CVID) and chronic granulomatous disease (CGD). Curr Gastroenterol Rep. 2016;18:17–29.

    PubMed  PubMed Central  Google Scholar 

  72. Bigotti G, Coli A, Magistrelli P, De Ninno M, Antonacci V, Crucitti A, Federico F, Antinori A, Massi G. Gastric adenocarcinoma associated with granulomatous gastritis. Case report and review of the literature. Tumori. 2002;88(2):163–6.

    PubMed  Google Scholar 

  73. El Demellawy D, Otero C, Radhi J. Primary gastric lymphoma with florid granulomatous reaction. J Gastrointest Liver Dis. 2009;18(1):99–101.

    Google Scholar 

  74. Barros MHM, Leite E, Chabay P, et al. Diagnosing lymphoma in a setting with a high burden of infection: a pediatric case of Epstein-Barr virus-associated aggressive B-cell lymphoma with t(8,14) (q23;q32) and extensive necrosis mimicking tuberculosis. Rev Soc Bras Med Trop. 2015;48:108–11.

    PubMed  Google Scholar 

  75. Niitsu H, Tanabe K, Tokumoto N, et al. Idiopathic granulomatous gastritis resembling a gastrointestinal stromal tumor. Case Rep Gastroenterol. 2012;6:502–9.

    PubMed  PubMed Central  Google Scholar 

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  1. Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Kim Vaiphei

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Vaiphei, K. (2022). Uncommon Types of Gastritis and Gastropathies Including Anti-parietal Cell, GVHD, Reactive and Granulomatous Gastritis. In: Interpretation of Endoscopic Biopsy - Gastritis, Gastropathies and Beyond. Springer, Singapore. https://doi.org/10.1007/978-981-16-6026-9_19

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