Skip to main content

Handling of Endoscopic Resected Specimen: Indication for ESD and Grossing of ESD Specimen

  • Chapter
  • First Online:
Interpretation of Endoscopic Biopsy - Gastritis, Gastropathies and Beyond
  • 757 Accesses

Abstract

Treatment for early gastric cancer is carried out with maximum tissue preservation so that the patient may lead a normal life after the definite treatment. Endoscopic mucosal resection is one such step. Handling of such resected specimen at grossing is of utmost importance for proper and complete reporting.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Vieth M, Langner C, Neumann H, et al. Barrett’s esophagus. Practical issues for daily routine diagnosis. Pathol Res Pract. 2012;208:261–8.

    Article  PubMed  Google Scholar 

  2. Bejarano PA, Berho M. Examination of surgical specimens of the esophagus. Arch Pathol Lab Med. 2015;139:1446–54.

    Article  CAS  PubMed  Google Scholar 

  3. Participants in Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon. Gastrointest Endosc. 2003;58:S3–S43.

    Article  Google Scholar 

  4. Brahmania M, Lam E, Telford J, et al. Endoscopic mucosal resection: early experience in British Columbia. Can J Gastroenterol. 2010;24:239–44.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Scudiere JR, Montgomery EA. New treatments, new challenges: Pathology’s perspective on esophageal carcinoma. Gastroenterol Clin N Am. 2009;38:121–33.

    Article  Google Scholar 

  6. Geramizadeh B, Owen D. Handling and pathology reporting of gastrointestinal endoscopic mucosal resection. Middle East J Dig Dis. 2017;9:5–11.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Inoue H, Minami H, Kaga M, et al. Endoscopic mucosal resection and endoscopic submucosal dissection for esophageal dysplasia and carcinoma. Gastrointest Endosc Clin N Am. 2010;20:25–34.

    Article  PubMed  Google Scholar 

  8. Zhou PH, Schumacher B, Yao LQ, et al. Conventional vs. waterjet-assisted endoscopic submucosal dissection in early gastric cancer: a randomized controlled trial. Authors Endoscopy. 2014;46:836–42.

    Google Scholar 

  9. Nagata K, Shimizu M. Pathological evaluation of gastrointestinal endoscopic submucosal dissection materials based on Japanese guidelines. World J Gastrointest Endosc. 2012;4:489–99.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Höbel S, Dautel P, Baumbach R, et al. Single center experience of endoscopic submucosal dissection (ESD) in early Barrett’s adenocarcinoma. Surg Endosc. 2015;29:1591–7.

    Article  PubMed  Google Scholar 

  11. Chevaux JB, Piessevaux H, Jouret-Mourin A, et al. Clinical outcome in patients treated with endoscopic submucosal dissection for superficial Barrett’s neoplasia. Endoscopy. 2015;47:103–12.

    Article  PubMed  Google Scholar 

  12. Mino-Kenudson M, Brugge WR, Puricelli WP, et al. Management of superficial Barrett’s epithelium-related neoplasms by endoscopic mucosal resection: clinicopathologic analysis of 27 cases. Am J Surg Pathol. 2005;29:680–6.

    Article  PubMed  Google Scholar 

  13. Oyama T, Tomori A, Hotta K, et al. Endoscopic submucosal dissection of early esophageal cancer. Clin Gastroenterol Hepatol. 2005;3:S67–70.

    Article  PubMed  Google Scholar 

  14. Ono H. Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes. Eur J Gastroenterol Hepatol. 2006;18:863–6.

    Article  PubMed  Google Scholar 

  15. Japanese gastric cancer association. Gastric cancer treatment guidelines. 3rd ed. Tokyo: Kanehara; 2010.

    Google Scholar 

  16. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011;14:113–23.

    Article  Google Scholar 

  17. Abe N, Watanabe T, Suzuki K, et al. Risk factors predictive of lymph node metastasis in depressed early gastric cancer. Am J Surg. 2002;183:168–72.

    Article  PubMed  Google Scholar 

  18. Kunisaki C, Takahashi M, Nagahori Y, et al. Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer. Endoscopy. 2009;41:498–503.

    Article  CAS  PubMed  Google Scholar 

  19. Yamao T, Shirao K, Ono H, et al. Risk factors for lymph node metastasis from intramucosal gastric carcinoma. Cancer. 1996;77:602–6.

    Article  CAS  PubMed  Google Scholar 

  20. Mita T, Shimoda T. Risk factors for lymph node metastasis of submucosal invasive differentiated type gastric carcinoma: clinical significance of histological heterogeneity. J Gastroenterol. 2001;36:661–8.

    Article  CAS  PubMed  Google Scholar 

  21. Alvarez Herrero L, Pouw RE, van Vilsteren FG, et al. Risk of lymph node metastasis associated with deeper invasion by early adenocarcinoma of the esophagus and cardia: study based on endoscopic resection specimens. Endoscopy. 2010;42:1030–6.

    Article  CAS  PubMed  Google Scholar 

  22. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3:219–25.

    Article  PubMed  Google Scholar 

  23. Nishizawa T, Yahagi N. Long-term outcomes of using endoscopic submucosal dissection to treat early gastric cancer. Gut Liver. 2018;12:119–24.

    Article  PubMed  Google Scholar 

  24. Hirasawa T, Gotoda T, Miyata S, et al. Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer. Gastric Cancer. 2009;12:148–52.

    Article  PubMed  Google Scholar 

  25. Hanaoka N, Tanabe S, Mikami T, et al. Mixed-histologic-type submucosal invasive gastric cancer as a risk factor for lymph node metastasis: feasibility of endoscopic submucosal dissection. Endoscopy. 2009;41:427–32.

    Article  CAS  PubMed  Google Scholar 

  26. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49.

    Article  CAS  PubMed  Google Scholar 

  27. Sako A, Kitayama J, Ishikawa M, et al. Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer. Gastric Cancer. 2006;9:295–302.

    Article  PubMed  Google Scholar 

  28. Yonemura Y, Endou Y, Tabachi K, et al. Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40. Hum Pathol. 2006;37:1193–9.

    Article  CAS  PubMed  Google Scholar 

  29. del Casar JM, Corte MD, Alvarez A, et al. Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance. J Cancer Res Clin Oncol. 2008;134:153–61.

    Article  CAS  PubMed  Google Scholar 

  30. Sugai T, Inomata M, Uesugi N, et al. Analysis of mucin, p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic lesions obtained from endoscopic mucosal resection samples: a proposal for a new classification of intramucosal neoplastic lesions based on nuclear atypia. Pathol Int. 2004;54:425–35.

    Article  CAS  PubMed  Google Scholar 

  31. Ko WJ, Song GW, Kim WH, et al. Endoscopic resection of early gastric cancer: current status and new approaches. Transl Gastroenterol Hepatol. 2016;1:24.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Korea ESD Study Group. Clinical outcomes of endoscopic resection for low-grade dysplasia and high-grade dysplasia on gastric pre-treatment biopsy. Gut Liver. 2021;15:225–31.

    Article  Google Scholar 

  33. Nishizawa T, Suzuki H, Arano T, et al. Characteristics of gastric cancer detected within 1 year after successful eradication of helicobacter pylori. J Clin Biochem Nutr. 2016;59:226–30.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Choi MK, Kim GH, Park DY, et al. Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single center experience. Surg Endosc. 2013;27:4250–8.

    Article  PubMed  Google Scholar 

  35. Nakamura K, Honda K, Akahoshi K, et al. Suitability of the expanded indication criteria for the treatment of early gastric cancer by endoscopic submucosal dissection: Japanese multicenter largescale retrospective analysis of short- and long-term outcomes. Scand J Gastroenterol. 2015;50:413–22.

    Article  PubMed  Google Scholar 

  36. Min BH, Kim KM, Park CK, et al. Outcomes of endoscopic submucosal dissection for differentiated-type early gastric cancer with histological heterogeneity. Gastric Cancer. 2015;18:618–26.

    Article  PubMed  Google Scholar 

  37. Abe S, Oda I, Suzuki H, et al. Short- and long-term outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer. Endoscopy. 2013;45:703–7.

    Article  PubMed  Google Scholar 

  38. Yamamoto Y, Fujisaki J, Miyamoto Y, et al. The long term prognosis of expanded indication lesion of endoscopic submucosal dissection for undifferentiated type early gastric cancer. Stomach Intest. 2014;49:1569–77.

    Google Scholar 

  39. Fukunaga S, Nagami Y, Shiba M, et al. Long-term prognosis of expanded-indication differentiated-type early gastric cancer treated with endoscopic submucosal dissection or surgery using propensity score analysis. Gastrointest Endosc. 2017;85:143–52.

    Article  PubMed  Google Scholar 

  40. Kabashima A, Yao T, Sugimachi K, et al. Relationship between biologic behaviour and phenotypic expression in Intramucosal gastric carcinomas. Hum Pathol. 2002;33:80–6.

    Article  PubMed  Google Scholar 

  41. Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann. 1968;59:252–8.

    Google Scholar 

  42. Tatematsu M, Ichinose M, Miki K, et al. Gastric intestinal phenotypic expression of human stomach cancers as revealed by peptinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn. 1990;40:494–504.

    CAS  PubMed  Google Scholar 

  43. Egashira Y. Mucin histochemical study of differentiated adenocarcinoma of stomach. Jpn J Gastroenterol. 1994;91:839–48.

    CAS  Google Scholar 

  44. Yao T, Kabashima A, Kouzuki T, et al. The phenotypes of the gastric carcinoma—evaluation by a new immunohistochemical method. I To Cho (Stomach Intestine). 1999;34:477–85.

    Google Scholar 

  45. Kabashuma A, Yao T, Tsuneyoshi M. Gastric and intestinal phenotypic expression in the carcinomas and background mucosa of multiple early gastric carcinomas. Histopathology. 2000;37:513–22.

    Article  Google Scholar 

  46. Endoh Y, Tamura G, Motoyama T, et al. Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach. Hum Pathol. 1999;30:826–32.

    Article  CAS  PubMed  Google Scholar 

  47. Yoshino T, Shimoda T, Saitou A, et al. Macroscopic features of differentiated gastric adenocarcinoma with gastric or intestinal phenotype expression in early gastric cancer. I To Cho (Stomach Intestine). 1999;34:507–25.

    Google Scholar 

  48. Kubo K, Yanagisawa A, Ninomiya Y, et al. Characteristics of differentiated-type carcinoma with gastric phenotype of the stomach. I To Cho (Stomach Intestine). 1999;34:487–94.

    Google Scholar 

  49. Koseki K, Takizawa T, Koike M, et al. Subclassification of well differentiated gastric cancer with reference to biological behaviour and malignancy, gastric type vs. intestinal type, and papillary carcinoma vs. tubular carcinoma. I To Cho (Stomach Intestine). 1999;34:507–12.

    Google Scholar 

  50. Oya M, Yao T, Tsuneyoshi M. A correlation of intramural invasion with mucin histochemistry, and immunohistochemical expressions of oncogene-related proteins in early gastric carcinoma. I To Cho (Stomach Intestine). 1997;32:31–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kim Vaiphei .

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vaiphei, K. (2022). Handling of Endoscopic Resected Specimen: Indication for ESD and Grossing of ESD Specimen. In: Interpretation of Endoscopic Biopsy - Gastritis, Gastropathies and Beyond. Springer, Singapore. https://doi.org/10.1007/978-981-16-6026-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-981-16-6026-9_12

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-6025-2

  • Online ISBN: 978-981-16-6026-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics