Abstract
Mesenchymal stem cells (MSC) are specific cell types that enable tissue renewal within the body and are activated during the regeneration processes in response to injury. These cells are present in all human and animal tissues. In medical and biological research, MSCs are isolated and purified from the donor organism and cultured in vitro before use in the treatment of a variety of diseases and conditions associated with tissue damage and cell loss, including ocular lesions. This approach is called cell-based therapy or regenerative medicine. Despite the many existing therapeutic strategies in the area of cell therapy in relation to curing ocular diseases in recent years, advances and new regenerative therapy methods have also been developed and consolidated, giving us a new perspective. Therefore, it is necessary to implement standardization and comparison of cell therapy results. Experimentation using animal models has played a central role in biomedical research. The safety and efficacy of new drugs are usually tested in animal models of human diseases prior to entering human clinical trials. Nevertheless, the pathophysiological mechanisms of eye diseases are complex and multifactorial; hence it is crucial that experimental animal models with clinical relevance provide adequate information and sufficiently replicate the eye diseases being assessed and demonstrate the effects of MSC therapy.
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Abbreviations
- ADMSC:
-
Adipose-derived mesenchymal stem cells
- AMD:
-
Age-related macular degeneration
- BDNF:
-
Brain-derived neurotrophic factor
- BMSC:
-
Bone marrow stromal cells
- CNV:
-
Choroidal neovascularization
- DR:
-
Diabetic retinopathy
- ES:
-
Embryonic stem cells
- GCL:
-
Ganglion cell layer
- GFP:
-
Green fluorescent protein
- PVPC:
-
Multipotent perivascular progenitor cells derived from human
- hESC:
-
Embryonic stem cells
- hRPC:
-
Human retinal progenitor cells
- LEC:
-
Lens epithelial cells
- LHON:
-
Leberโs hereditary optic neuropathy
- MSC:
-
Mesenchymal stem cells
- NF1:
-
Neurofibromatosis type 1
- POAG:
-
Primary open-angle glaucoma
- RCS:
-
Retinal dystrophy of Royal College of Surgeons rats
- RGC:
-
Retinal ganglion cells
- RP:
-
Retinitis pigmentosa
- RPE:
-
Retinal pigment epithelial cells
- SC:
-
Stem cells
- UMSC:
-
Umbilical cord mesenchymal stem cells
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This work was funded by the subsidy allocated to KFU for the state assignment 0671-2020-0058 in the sphere of scientific activities. This work is part of the Kazan Federal University Strategic Academic Leadership Program.
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Zakirova, E., Aimaletdinov, A.M., Malanyeva, A.G., Rutland, ะก.S., Rizvanov, A.A. (2022). Preclinical Research of Mesenchymal Stem Cell-Based Therapy for Ocular Diseases. In: Haider, K.H. (eds) Handbook of Stem Cell Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-16-6016-0_12-1
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