Abstract
To observe the effect of modafinil on the visual function of 16-h flight. Methods 5 male healthy subjects were double-blind: placebo group (n = 5) and modafinil group (n = 5), Autologous control. Carry out 16 h (h) continuous simulated long flight test across day and night. First, the visual function is detected before flight, In pairs, at the same time, First phase 8 h at 15:30, After 200 mg, of modafenib or placebo 00:00 Completion of phase 2 h 8 flights, After the flight, the visual function was detected again and the state changes of far and near vision were compared before and after the flight. Results Compared with placebo, the use of modafinil had no significant effect on far and near vision, but increased the long vision of both eyes during flight. Conclusion Routine single dose of modafinil has no significant adverse effect on visual function and can reduce human fatigue perception.
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Acknowledgements
This work is supported by the Military Medical Research Foundation, China, No. AKJ15J002. Feng Wu and Dawei Tian contributed equally to this work.
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The study was approved by the Logistics Department for Civilian Ethics Committee of Air Force Medical Center.
All subjects who participated in the experiment were provided with and signed an informed consent form. All relevant ethical safeguards have been met with regard to subject protection.
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Tian, D. et al. (2022). The Influence of Modafini on the Visual Function of 16-hour Simulation Flight. In: Long, S., Dhillon, B.S. (eds) Man-Machine-Environment System Engineering: Proceedings of the 21st International Conference on MMESE. MMESE 2021. Lecture Notes in Electrical Engineering, vol 800. Springer, Singapore. https://doi.org/10.1007/978-981-16-5963-8_6
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DOI: https://doi.org/10.1007/978-981-16-5963-8_6
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