Abstract
Quantitative analysis by bone histomorphometry provides information about bone quality and dynamic bone turnover. In this chapter we present histomorphometric analysis of three specific systemic diseases with skeletal disorders. Histomorphometric assessments in hepatic C-associated osteosclerosis, IgG4-related disease, and Ehlers–Danlos syndrome were performed in these cases to clarify bone metabolism and structure. All these cases revealed unknown histomorphometric features in bone biopsies. Hepatic C-associated osteosclerosis demonstrated a thicker cortex with excessive bone formation, IgG4-related disease revealed unusual demineralization of bone, and Ehlers–Danlos syndrome indicated low turnover bone.
The present invited review was completed and submitted to the publisher on 30-May-20.
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References
Takahashi H, et al. Evidence that bone resorption proceeds formation at cellular level. Henry Ford Hosp Med Bull. 1964;12:359–64.
Parfitt AM, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987;2:595–610.
Dempster DW, et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2013;28:2–17.
Chavassieux P, et al. Clinical use of bone biopsy. In: Marcus R, editor. Osteoporosis. 2nd ed. Academic; 2001. p. 501–9.
Recker RR. Bone biopsy and histomorphometry in clinical practice, 7th ed. Primer on the metabolic bone disease and disorders of mineral metabolism, ASBMR; 2008. p. 180–6.
Recker RR, et al. Issues in modern bone histomorphometry. Bone. 2011;49:955–64.
Yamamoto N, et al. Bone cell biology assessed by microscopic approach. Bone histomorphometry of remodeling, modeling and minimodeling. Clin Calcium. 2015;25:1491–7.
Miyamura N, et al. A case of hepatitis C-associated osteosclerosis: accelerated bone turnover controlled by pulse steroid therapy. Endocri Diabet Metab. 2016.
Beighton P, et al. A review of the osteoscleroses. Postgrad Med J. 1977;53:507.
Whyte MP. Heritable metabolic and dysplastic bone disease. Endocrinol Metab Clin N Am. 1990;19:133.
Villareal DT, et al. Painful diffuse osteosclerosis after intravenous drug abuse. Am J Med. 1992;93:371–81.
Serraino C, et al. Hepatic C-associated osteosclerosis: a review of the literature. Intern Med. 2015;54:777–83.
Epperle N, et al. An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis. Skeletal Radiol. 2014;43:1313–8.
Khosla S, et al. Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis. J Clin Endocrinol Metab. 2002;87:3867–70.
Manganelli, et al. POPG/RANKL system imbalance in a case of hepatitis C-associated osteosclerosis: the pathogenetic key? 2005;24:296–300.
Kaji H, et al. Serum soluble factors induce the proliferation, alkaline phosphatase activity and transforming growth factor-beta signal in osteoblastic cells in the patient with hepatitis C-associated osteosclerosis. Exp Clin Endocrinol Diabetes. 2006;114:599–604.
Javier R, et al. Skeletal recovery from hepatitis C-associated osteosclerosis (HCAO) following antiviral treatment. Joint Bone Spine. 2011;78:409–11.
Hassoum AA, et al. Hepatic C-associated osteosclerosis: an unusual syndrome of acquired osteosclerosis in adults. Am J Med. 1997;103:70–3.
Kawakita C, et al. A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure. CEN Case Rep. 2019;8:23–30.
Bilezikian JP. Management of acute hypercalcemia. N Engl J Med. 1992;326:1196–203.
Umehara H, et al. A novel clinical entity, IgG4-related disease: general concept and details. Med Rheumatol. 2012;22:1–14.
Stone JH, et al. IgG4 disease. N Engl J Med. 2012;366:539–51.
Ichiki A, et al. IgG4-related disease with bone marrow involvement. Int Med. 2016;55:2295–9.
Uehara M, et al. Spinal manifestations in 12 patients with musculocontractural Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency (mcEDS-CHST14). Am L Med Genet. 2018;176:2331–41.
Steinmann B, Royce PM, Superti-Furga A. The Ehlers-Danlos syndrome. In: Royce PM, Steinmann B, editors. Connective tissue and its heritable disorders. New York: Wiley-Liss; 2002. p. 431–523.
Jasiewicz B, Potaczek T, Tesiorowski M, Lokas K. Spine deformities in patients with Ehlers-Danlos syndrome, type IV – late results of surgical treatment. Scoliosis. 2010;5:26.
Akpinar S, et al. Surgical management of the spinal deformity in Ehlers-Danlos syndrome type VI. Eur Spine J. 12;135–140.
Liu Y, et al. Posterior spinal fusion for scoliosis in Ehlers-Danlos syndrome, kyphoscoliosis type. Orthopedics. 2011;34:228.
Mazziotti G, et al. High prevalence of radiological vertebral fractures in adult patients with Ehlers-Danlos syndrome. Bone. 2016;84:88–92.
Eller-Vainicher C, et al. Bone involvement in adult patients affected with Ehlers-Danlos syndrome. Osteoporos Int. 2016;27:2525–31.
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Yamamoto, N. et al. (2022). Bone Histomorphometry in Miscellaneous Metabolic Diseases: Hepatic C-Associated Osteosclerosis, IgG4-Related Disease, and Ehlers–Danlos Syndrome. In: Takahashi, H.E., Burr, D.B., Yamamoto, N. (eds) Osteoporotic Fracture and Systemic Skeletal Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-16-5613-2_20
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