Skip to main content
SpringerLink
Log in

Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases

  • Chapter
  • First Online:
Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

  • 703 Accesses

Abstract

Chronic respiratory diseases include chronic obstructive pulmonary disease (COPD), pulmonary tuberculosis, idiopathic pulmonary fibrosis (IPF), cystic fibrosis, asthma, and lung cancers. These diseases have high mortality and morbidity rates. These persistent disorders are fatal in majority of the cases, and in advance stages, the damage done is non-repairable, almost null. There is still a significant need to carry out extensive research studies to establish liposomes as the most preferred drug carrier, especially for respiratory system related disorders. Therefor they seem to hold promise with their tremendous potential of targeting the desired site in the studies done so far.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Agee J (2007) 81 an approach to the child. Gen Pract 56:844

    Google Scholar 

  • Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8:102

    Article  PubMed  PubMed Central  Google Scholar 

  • Alpes H, Allmann K, Plattner H, Reichert J, Rick R, Schulz S (1986) Formation of large Unilamellar vesicles using alkyl Maltoside detergents. Biochim Biophys Acta Biomembr 862:294–302

    Article  CAS  Google Scholar 

  • Anderson CF, Grimmett ME, Domalewski CJ, Cui H (2020) Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol 12:E1586

    Article  CAS  PubMed  Google Scholar 

  • Atrooz O (2011) Effects of alkylresorcinolic lipids obtained from acetonic extract of Jordanian wheat grains on liposome properties. Int J Biol Chem 5:314–321

    Article  CAS  Google Scholar 

  • Bahadori M, Mohammadi F (2012) Nanomedicine for respiratory diseases. Tanaffos 11:18

    PubMed  PubMed Central  Google Scholar 

  • Baker KE, Bonvini SJ, Donovan C, Foong RE, Han B, Jha A, Shaifta Y, Smit M, Johnson JR, Moir LM (2014) Novel drug targets for asthma and Copd: lessons learned from in vitro and in vivo models. Pulm Pharmacol Ther 29:181–198

    Article  CAS  PubMed  Google Scholar 

  • Barenholz YC (2012) Doxil®—The first Fda-approved nano-drug: lessons learned. J Control Release 160:117–134

    Article  CAS  PubMed  Google Scholar 

  • Barker KF (1999) Antibiotic resistance: a current perspective. Br J Clin Pharmacol 48:109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Batzri S, Korn ED (1973) Single bilayer liposomes prepared without sonication. Biochim Biophys Acta Biomembr 298:1015–1019

    Article  CAS  Google Scholar 

  • Baughman R (1999) The lung in the immunocompromised patient. Respiration 66:95–109

    Article  CAS  PubMed  Google Scholar 

  • Bendas ER, Tadros MI (2007) Enhanced transdermal delivery of salbutamol sulfate via Ethosomes. AAPS PharmSciTech 8:213

    Article  PubMed Central  Google Scholar 

  • Benech R-O, Kheadr E, Laridi R, Lacroix C, Fliss I (2002) Inhibition of Listeria Innocua in Cheddar cheese by addition of Nisin Z in liposomes or by in situ production in mixed culture. Appl Environ Microbiol 68:3683–3690

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berne RM, Levy MN, Koeppen BM (2008) Berne & Levy physiology. Elsevier, Brasil

    Google Scholar 

  • Bhardwaj A, Kumar L, Narang R, Murthy R (2013) Development and characterization of ligand-appended liposomes for multiple drug therapy for pulmonary tuberculosis. Artific Cells Nanomed Biotechnol 41:52–59

    Article  CAS  Google Scholar 

  • Burgess DS (1999) Pharmacodynamic principles of antimicrobial therapy in the prevention of resistance. Chest 115:19s–23s

    Article  CAS  PubMed  Google Scholar 

  • Burns DM (2000) Primary prevention, smoking, and smoking cessation: implications for future trends in lung cancer prevention. Cancer 89:2506–2509

    Article  CAS  PubMed  Google Scholar 

  • Cagle PT, Allen TC, Olsen RJ (2013) Lung cancer biomarkers: present status and future developments. Arch Pathol Lab Med 137:1191–1198

    Article  CAS  PubMed  Google Scholar 

  • Champion JA, Mitragotri S (2009) Shape induced inhibition of phagocytosis of polymer particles. Pharm Res 26:244–249

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Huang W, Wong BC, Yin L, Wong YF, Xu M, Yang Z (2012) Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Int J Nanomedicine 7:1139

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cruz AA (2007) Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. World Health Organization, Geneva

    Google Scholar 

  • D’alonzo GE, Dantzker DR (1983) Respiratory failure, mechanisms of abnormal gas exchange, and oxygen delivery. Med Clin N Am 67:557–571

    Article  PubMed  Google Scholar 

  • Darquenne C, Fleming JS, Katz I, Martin AR, Schroeter J, Usmani OS, Venegas J, Schmid O (2016) Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung. J Aerosol Med Pulm Drug Deliv 29:107–126

    Article  PubMed  PubMed Central  Google Scholar 

  • De Backer L, Cerrada A, Pérez-Gil J, De Smedt SC, Raemdonck K (2015) Bio-inspired materials in drug delivery: exploring the role of pulmonary surfactant in Sirna inhalation therapy. J Control Release 220:642–650

    Article  PubMed  Google Scholar 

  • Deamer D, Bangham A (1976) Large volume liposomes by an ether vaporization method. Biochim Biophys Acta Biomembr 443:629–634

    Article  CAS  Google Scholar 

  • Dharmadhikari AS, Mphahlele M, Venter K, Stoltz A, Mathebula R, Masotla T, Van Der Walt M, Pagano M, Jensen P, Nardell E (2014) Rapid impact of effective treatment on transmission of multidrug-resistant tuberculosis. Int J Tuberc Lung Dis 18:1019–1025

    Article  CAS  PubMed  Google Scholar 

  • Drake R, Vogl AW, Mitchell AW (2009) Gray’s anatomy for students E-book. Elsevier Health Sciences TW

    Google Scholar 

  • Durham AL, Caramori G, Chung KF, Adcock IM (2016) Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease. Transl Res 167:192–203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dye C, Williams BG (2010) The population dynamics and control of tuberculosis. Science 328:856–861

    Article  CAS  PubMed  Google Scholar 

  • Escombe AR, Moore DA, Gilman RH, Pan W, Navincopa M, Ticona E, Martínez C, Caviedes L, Sheen P, Gonzalez A (2008) The infectiousness of tuberculosis patients Coinfected with HIV. PLoS Med 5:E188

    Article  PubMed  PubMed Central  Google Scholar 

  • Fujita Y, Takeshita F, Kuwano K, Ochiya T (2013) Rnai therapeutic platforms for lung diseases. Pharmaceuticals 6:223–250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gabizon A, Goren D, Cohen R, Barenholz Y (1998) Development of liposomal anthracyclines: from basics to clinical applications. J Control Release 53:275–279

    Article  CAS  PubMed  Google Scholar 

  • Ganong WF (1995) Review of medical physiology. Mcgraw-Hill, Lange, USA

    Google Scholar 

  • Gao L, Tao Y, Zhang L, Jin Q (2010) Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and Meta-analysis. Int J Tuberc Lung Dis 14:15–23

    CAS  PubMed  Google Scholar 

  • Greene KE, Peters JI (1994) Pathophysiology of acute respiratory failure. Clin Chest Med 15:1–12

    Article  CAS  PubMed  Google Scholar 

  • Halbert R, Natoli J, Gano A, Badamgarav E, Buist AS, Mannino D (2006) Global burden of Copd: systematic review and meta-analysis. Eur Respir J 28:523–532

    Article  CAS  PubMed  Google Scholar 

  • Henning A, Schneider M, Nafee N, Muijs L, Rytting E, Wang X, Kissel T, Grafahrend D, Klee D, Lehr C-M (2010) Influence of particle size and material properties on mucociliary clearance from the airways. J Aerosol Med Pulm Drug Deliv 23:233–241

    Article  CAS  PubMed  Google Scholar 

  • Hofheinz R-D, Gnad-Vogt SU, Beyer U, Hochhaus A (2005) Liposomal encapsulated anti-cancer drugs. Anti Cancer Drugs 16:691–707

    Article  CAS  PubMed  Google Scholar 

  • Holgate ST, Polosa R (2006) The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 368:780–793

    Article  CAS  PubMed  Google Scholar 

  • Hua S (2013) Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies. Front Pharmacol 4:127

    Article  PubMed  PubMed Central  Google Scholar 

  • Jain V, Bhardwaj A (2019) Pneumonia pathology. Statpearls [internet]. Statpearls Publishing, Treasure Island (FL)

    Google Scholar 

  • Janssens J-P, Pache J-C, Nicod L (1999) Physiological changes in respiratory function associated with ageing. Eur Respir J 13:197–205

    Article  CAS  PubMed  Google Scholar 

  • Jin J, Hu K, Zhou Y, Li W (2017) Clinical utility of the modified Glasgow prognostic score in lung cancer: a meta-analysis. PLoS One 12:E0184412

    Article  PubMed  PubMed Central  Google Scholar 

  • Johnson L (1998) Essential medical physiology. Lippincott, Philadelphia, PA, pp 468–472

    Google Scholar 

  • Johnston MJ, Semple SC, Klimuk SK, Ansell S, Maurer N, Cullis PR (2007) Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochim Biophys Acta Biomembr 1768:1121–1127

    Article  CAS  Google Scholar 

  • Karn PR, Vanić Z, Pepić I, Å kalko-Basnet N (2011) Mucoadhesive liposomal delivery systems: the choice of coating material. Drug Dev Ind Pharm 37:482–488

    Article  CAS  PubMed  Google Scholar 

  • Kataria S, Sandhu P, Bilandi A, Akanksha M, Kapoor B (2011) Stealth liposomes: a review. Int J Res Ayurveda Pharm 2

    Google Scholar 

  • Kelly HW, Murphy S (1992) Beta-adrenergic agonists for acute, severe asthma. Ann Pharmacother 26:81–91

    Article  CAS  PubMed  Google Scholar 

  • Kelly C, Jefferies C, Cryan S-A (2011) Targeted liposomal drug delivery to monocytes and macrophages. J Drug Del 2011

    Google Scholar 

  • Kleinnijenhuis J, Joosten LA, Van De Veerdonk FL, Savage N, Van Crevel R, Kullberg BJ, Van Der Ven A, Ottenhoff TH, Dinarello CA, Van Der Meer JW (2009) Transcriptional and Inflammasome-mediated pathways for the induction of Il-1β production by Mycobacterium Tuberculosis. Eur J Immunol 39:1914–1922

    Article  CAS  PubMed  Google Scholar 

  • Kocher F, Hilbe W, Seeber A, Pircher A, Schmid T, Greil R, Auberger J, Nevinny-Stickel M, Sterlacci W, Tzankov A (2015) Longitudinal analysis of 2293 Nsclc patients: a comprehensive study from the Tyrol registry. Lung Cancer 87:193–200

    Article  PubMed  Google Scholar 

  • Kumana CR, Yuen KY (1994) Parenteral aminoglycoside therapy. Drugs 47:902–913

    Article  CAS  PubMed  Google Scholar 

  • Lai SK, Suk JS, Pace A, Wang Y-Y, Yang M, Mert O, Chen J, Kim J, Hanes J (2011) Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials 32:6285–6290

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee W-H, Loo C-Y, Traini D, Young PM (2015) Nano-and micro-based inhaled drug delivery systems for targeting alveolar macrophages. Expert Opin Drug Deliv 12:1009–1026

    Article  CAS  PubMed  Google Scholar 

  • Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar J-S, Squire J (2013) Molecular testing guideline for selection of lung Cancer patients for Egfr and Alk tyrosine kinase inhibitors: guideline from the college of American pathologists, international association for the study of lung cancer, and association for molecular pathology. J Thorac Oncol 8:823–859

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, Colasacco C, Dacic S, Hirsch FR, Kerr K (2018) Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors: guideline from the college of American pathologists, the international association for the study of lung cancer, and the association for molecular pathology. J Thorac Oncol 13:323–358

    Article  CAS  PubMed  Google Scholar 

  • Lombry C, Edwards DA, Préat V, Vanbever R (2004) Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules. Am J Phys Lung Cell Mol Phys 286:L1002–L1008

    CAS  Google Scholar 

  • Mälkki-Laine L, Purra K, Kähkönen K, Tammilehto S (1995) Decomposition of salbutamol in aqueous solutions. Ii. The effect of buffer species, Ph, buffer concentration and antioxidants. Int J Pharm 117:189–195

    Article  Google Scholar 

  • Maslan J, Mims JW (2014) What is asthma? Pathophysiology, demographics, and health care costs. Otolaryngol Clin N Am 47:13–22

    Article  Google Scholar 

  • Masoli M, Fabian D, Holt S, Beasley R, Program GIFA (2004) The global burden of asthma: executive summary of the Gina dissemination committee report. Allergy 59:469–478

    Article  PubMed  Google Scholar 

  • Mayer LD, Bally MB, Hope MJ, Cullis PR (1986) Techniques for encapsulating bioactive agents into liposomes. Chem Phys Lipids 40:333–345

    Article  CAS  PubMed  Google Scholar 

  • Møller H, Jørgensen N, Forman D (1995) Trends in incidence of testicular cancer in boys and adolescent men. Int J Cancer 61:761–764

    Article  PubMed  Google Scholar 

  • Moller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Haussinger K, Kreyling WG (2008) Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 177:426–432

    Article  PubMed  Google Scholar 

  • Moore KL, Dalley AF (2018) Clinically oriented anatomy. Wolters Kluwer India Pvt Ltd., India

    Google Scholar 

  • Mosgoeller W, Prassl R, Zimmer A (2012) Nanoparticle-mediated treatment of pulmonary arterial hypertension. Methods in Enzymology 508:325–354

    Article  CAS  PubMed  Google Scholar 

  • Mozafari MR (2005) Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett 10:711

    CAS  PubMed  Google Scholar 

  • Nizet T, Broeders M, Folgering HTM (2004) Tremor side effects of salbutamol, quantified by a laser pointer technique. Respir Med 98:844–850

    Article  CAS  PubMed  Google Scholar 

  • Nunn A, Phillips PP, Abubakar I (2013) Treatment of pulmonary tuberculosis. Curr Opin Pulm Med 19:273–279

    Article  PubMed  Google Scholar 

  • Oyen WJ, Boerman OC, Storm G, Bloois LV, Koenders EB, Claessens RA, Perenboom RM, Crommelin DJ, Van Der Meer JW, Corstens FH (1996) Detecting infection and inflammation with technetium-99m-labeled stealth liposomes. J Nucl Med 37(8):1392–1397

    CAS  PubMed  Google Scholar 

  • Pocock G, Richards CD, Richards DA (2013) Human physiology. Oxford University Press, Oxford

    Google Scholar 

  • Raesch SS, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge CA, Perez-Gil J, Schaefer UF, Lehr C-M (2015) Proteomic and Lipidomic analysis of nanoparticle corona upon contact with lung surfactant reveals differences in protein, but not lipid composition. ACS Nano 9:11872–11885

    Article  CAS  PubMed  Google Scholar 

  • Ramakrishnan L (2012) Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol 12:352–366

    Article  CAS  PubMed  Google Scholar 

  • Ratemi E, Sultana Shaik A, Al Faraj A, Halwani R (2016) Alternative approaches for the treatment of airway diseases: focus on nanoparticle medicine. Clin Exp Allergy 46:1033–1042

    Article  CAS  PubMed  Google Scholar 

  • Restrepo RD (2007) Inhaled adrenergics and anticholinergics in obstructive lung disease: do they enhance mucociliary clearance? Respir Care 52:1159–1175

    PubMed  Google Scholar 

  • Riaz M (1996) Liposomes preparation methods. Pak J Pharm Sci 9:65–77

    CAS  PubMed  Google Scholar 

  • Robertson JD, Ward JR, Avila-Olias M, Battaglia G, Renshaw SA (2017) Targeting neutrophilic inflammation using polymersome-mediated cellular delivery. J Immunol 198:3596–3604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruppert C, Schmidt R, Grimminger F, Suzuki Y, Seeger W, Lehr C-M, Günther A (2002) Chemical coupling of a monoclonal antisurfactant protein-B antibody to human Urokinase for targeting surfactant-incorporating alveolar fibrin. Bioconjug Chem 13:804–811

    Article  CAS  PubMed  Google Scholar 

  • Sáenz B, Hernandez-Pando R, Fragoso G, Bottasso O, Cárdenas G (2013) The dual face of central nervous system tuberculosis: a new Janus Bifrons? Tuberculosis 93:130–135

    Article  PubMed  Google Scholar 

  • Sahoo SK, Labhasetwar V (2003) Nanotech approaches to drug delivery and imaging. Drug Discov Today 8:1112–1120

    Article  CAS  PubMed  Google Scholar 

  • Sahoo B, Devi KSP, Banerjee R, Maiti TK, Pramanik P, Dhara D (2013) Thermal and Ph responsive polymer-tethered multifunctional magnetic nanoparticles for targeted delivery of anticancer drug. ACS Appl Mater Interfaces 5:3884–3893

    Article  CAS  PubMed  Google Scholar 

  • Samet JM (2018) Lung cancer, smoking, and obesity: it’s complicated. Oxford University Press, Oxford

    Google Scholar 

  • Schieren H, Rudolph S, Finkelstein M, Coleman P, Weissmann G (1978) Comparison of large Unilamellar vesicles prepared by a petroleum ether vaporization method with multilamellar vesicles: Esr, diffusion and entrapment analyses. Biochim Biophys Acta Gen Sub 542:137–153

    Article  CAS  Google Scholar 

  • Schiffelers RM, Bakker-Woudenberg IA, Snijders SV, Storm G (1999) Localization of sterically stabilized liposomes in Klebsiella Pneumoniae-infected rat lung tissue: influence of liposome characteristics. Biochim Biophys Acta Biomembr 1421:329–339

    Article  CAS  Google Scholar 

  • Schiffelers RM, Bakker-Woudenberg IA, Storm G (2000) Localization of sterically stabilized liposomes in experimental rat Klebsiella Pneumoniae pneumonia: dependence on circulation kinetics and presence of poly (ethylene) glycol coating. Biochim Biophys Acta Biomembr 1468:253–261

    Article  CAS  Google Scholar 

  • Schiffelers RM, Storm G, Marian T, Bakker-Woudenberg IA (2001) Therapeutic efficacy of liposome-encapsulated gentamicin in rat Klebsiella Pneumoniae pneumonia in relation to impaired host defense and low bacterial susceptibility to gentamicin. Antimicrob Agents Chemother 45:464–470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schmidt-Rohr K (2020) Oxygen is the high-energy molecule powering complex multicellular life: fundamental corrections to traditional bioenergetics. Acs Omega 5:2221–2233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shaheen SM, Shakil Ahmed F, Hossen MN, Ahmed M, Amran MS, Ul-Islam M (2006) Liposome as a carrier for advanced drug delivery. Pak J Biol Sci 9:1181–1191

    Article  CAS  Google Scholar 

  • Sharma A, Sharma US (1997) Liposomes in drug delivery: progress and limitations. Int J Pharm 154:123–140

    Article  CAS  Google Scholar 

  • Shehata T, Ogawara K-I, Higaki K, Kimura T (2008) Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers. Int J Pharm 359:272–279

    Article  CAS  PubMed  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30

    Article  Google Scholar 

  • Smola M, Vandamme T, Sokolowski A (2008) Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. Int J Nanomedicine 3:1

    CAS  PubMed  PubMed Central  Google Scholar 

  • Song H, Geng H, Ruan J, Wang K, Bao C, Wang J, Peng X, Zhang X, Cui D (2011) Development of polysorbate 80/phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. Nanoscale Res Lett 6:354

    Article  PubMed  PubMed Central  Google Scholar 

  • Sullivan JT, Young EF, Mccann JR, Braunstein M (2012) The Mycobacterium Tuberculosis Seca2 system subverts phagosome maturation to promote growth in macrophages. Infect Immun 80:996–1006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sweetman SC (2009) Martindale: the complete drug reference. Pharmaceutical Press, London

    Google Scholar 

  • Todoroff J, Vanbever R (2011) Fate of nanomedicines in the lungs. Curr Opin Colloid Interface Sci 16:246–254

    Article  CAS  Google Scholar 

  • Tortora GJ, Derrickson BH (2018) Principles of anatomy and physiology. John Wiley & Sons Inc., USA

    Google Scholar 

  • Tu J, Inthavong K, Ahmadi G (2012) Computational fluid and particle dynamics in the human respiratory system. Springer Science & Business Media, Germany

    Google Scholar 

  • Van Crevel R, Ottenhoff TH, Van Der Meer JW (2002) Innate immunity to Mycobacterium Tuberculosis. Clin Microbiol Rev 15:294–309

    Article  PubMed  PubMed Central  Google Scholar 

  • Wagner A, Vorauer-Uhl K (2011) Liposome technology for industrial purposes. J Drug Deliv 2011

    Google Scholar 

  • Wan C, Allen T, Cullis P (2014) Lipid nanoparticle delivery systems for Sirna-based therapeutics. Drug Deliv Transl Res 4:74–83

    Article  CAS  PubMed  Google Scholar 

  • Wasthi V, Goins B, Klipper R, Loredo R, Korvick D, Phillips WT (1998) Imaging experimental osteomyelitis using radiolabeled liposomes. J Nucl Med 39:1089–1094

    Google Scholar 

  • Wheeler CJ, Felgner PL, Tsai YJ, Marshall J, Sukhu L, Doh SG, Hartikka J, Nietupski J, Manthorpe M, Nichols M (1996) A novel cationic lipid greatly enhances plasmid Dna delivery and expression in mouse lung. Proc Natl Acad Sci 93:11454–11459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Williams SG, Schmidt DK, Redd SC, Storms W (2003) Key clinical activities for quality asthma care. Recommendations of the national asthma education and prevention program. MMWR Recomm Rep 52:1–8

    PubMed  Google Scholar 

  • Witts L (1962) Year book of medicine. Br Med J 1:1188

    Article  PubMed Central  Google Scholar 

  • World Health Organization (2013) Global tuberculosis report 2013. World Health Organization

    Google Scholar 

  • Ww B (2001) Lemanske Rf Jr. Asthma. N Engl J Med 344:350–362

    Google Scholar 

  • Zhang Y (2011) Relationship between size and function of natural substance particles. Nano Biomed Eng 3

    Google Scholar 

  • Zhang T, Chen Y, Ge Y, Hu Y, Li M, Jin Y (2018) Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers. Acta Pharm Sin B 8:440–448

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

    Mangesh Pradeep Kulkarni & Rajesh Kumar

  2. University of Greenwich, Kent, UK

    Poluri Sesha Sai Kiran

Authors
  1. Mangesh Pradeep Kulkarni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Poluri Sesha Sai Kiran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rajesh Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  2. Regulatory Affairs Coordinator, Bioproperties Pty Ltd, Glenorie, NSW, Australia

    Kavita Pabreja

  3. School of Pharmacy, Al-Karim University, Katihar, Bihar, India

    Md. Faiyazuddin

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kulkarni, M.P., Kiran, P.S.S., Kumar, R. (2022). Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases. In: Chellappan, D.K., Pabreja, K., Faiyazuddin, M. (eds) Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases . Springer, Singapore. https://doi.org/10.1007/978-981-16-4392-7_20

Download citation

Publish with us

Policies and ethics

Search

Navigation