Abstract
A steady rise in the use of point-of-care devices is warranted by the growing demand for medical attention and increased use of portable biosensing devices across various industries in different domains. Portable point-of-care devices provide simple, cost- and time-effective, reliable detection of various chemicals such as biomolecules, toxins or environmental pollutants, and microscopic entities such as parasites, viruses, bacteria and other pathogens. Among different biosensors, optical biosensors offer high sensitivity in the range of 10−6–10−8 RIU, real-time monitoring capability, cost-effectiveness, rapidity and compatibility to miniaturization. The versatility of this class of biosensors makes them attractive candidates, holding promising potential for use as next-generation point-of-care testing devices.
Optical biosensors use optical field parameters such as the amplitude, frequency, phase and polarization state to probe molecular interactions. Optical biosensors can be classified into label-based (e.g. fluorescence) and label-free (e.g. surface plasmon resonance) biosensors. Advances in the optical biosensing domain towards integrated optics, integration of microfluidic technology and microelectromechanical systems-assisted sensor fabrication techniques have significantly contributed to the field as they facilitate the fabrication and development of portable, cost-effective and high-throughput optical biosensing device. Label-based techniques offer excellent sensitivity and specificity for interrogating biomolecular interactions. Whereas label-free techniques directly detect and interpret the changes in optical parameters of the incident light wave on the biomolecules embedded on sensor surfaces, without hindered by photo-bleaching or other limitations faced by marker-dependent approaches. This chapter provides a brief overview of currently available label-based and label-free biosensors and discusses the potential and key limitations that require further advances in the field to facilitate successful commercialization of these techniques.
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References
WHO.: Report of the third global survey on eHealth Global Observatory for eHealth Global diffusion of eHealth: Making universal health coverage achievable [Internet]. (2016), http://apps.who.int/bookorders
Christodouleas, D.C., Kaur, B., Chorti, P.: From point-of-care testing to eHealth diagnostic DEvices (eDiagnostics). ACS Cent. Sci. (2018)
Shaw, T., McGregor, D., Brunner, M., Keep, M., Janssen, A., Barnet, S.: What is eHealth (6)? Development of a conceptual model for ehealth: qualitative study with key informants. J. Med. Internet Res. (2017)
World Health Organization: Telemedicine: opportunities and developments report on the second global survey on eHealth Global Observatory for eHealth series-Volume 2 Telemedicine in Member States (2010)
Konwar, A.N., Borse, V.: Current status of point-of-care diagnostic devices in the Indian healthcare system with an update on COVID-19 pandemic. Sens. Int. 1, 100015 (2020a). Elsevier BV
Vikram, T.: Essence of point-of-care diagnostic testing (POCT) in remote healthcare in India [Internet]. https://www.linkedin.com/pulse/essence-point-of-care-diagnostic-testing-poct-remote-india-thaploo (2017)
Kosack, C.S., Page, A.L., Klatser, P.R.: A guide to aid the selection of diagnostic tests. Bull. World Health Organ. [Internet]. 95(9), 639–645 (2017). World Health Organization. https://pubmed.ncbi.nlm.nih.gov/28867844/
Luppa, P.B.: Point-of-care testing at the interface of emerging technologies and new clinical applications [Internet]. J. Lab. Med. 59–61 (2020). Walter de Gruyter GmbH, https://doi.org/10.1515/labmed-2020-0020
Purohit, B., Vernekar, P.R., Shetti, N.P., Chandra, P.: Biosensor nanoengineering: design, operation, and implementation for biomolecular analysis. Sens. Int. [Internet]. 1(July), 100040 (2020), Elsevier Ltd. https://doi.org/10.1016/j.sintl.2020.100040
Dincer, C., Bruch, R., Costa-Rama, E., Fernández-Abedul, M.T., Merkoçi, A., Manz, A., et al. Disposable sensors in diagnostics, food, and environmental monitoring. Adv. Mater. (2019)
Chen, C., Wang, J.: Optical biosensors: an exhaustive and comprehensive review. Anal. Royal Soc Chem.145(5), 1605–1628 (2020)
Damborský, P., Švitel, J., Katrlík, J.: Optical biosensors. Essays Biochem. 60(1), 91–100 (2016)
Huertas, C.S., Calvo-Lozano, O., Mitchell, A., Lechuga, L.M.: Advanced evanescent-wave optical biosensors for the detection of nucleic acids: an analytic perspective. Front. Chem. 1–25, 7(October). (2019a)
Long, F., Zhu, A., Shi, H.: Recent advances in optical biosensors for environmental monitoring and early warning. Sensors (Switzerland) (2013)
Dey, D., Goswami, T.: Optical biosensors: a revolution towards quantum nanoscale electronics device fabrication. J. Biomed Biotechnol. (2011)
Inan, H., Poyraz, M., Inci, F., Lifson, M.A., Baday, M., Cunningham, B.T., et al.: Photonic crystals: emerging biosensors and their promise for point-of-care applications. Chem. Soc. Rev. (2017)
Ulep, T.H., Yoon, J.Y.: Challenges in paper-based fluorogenic optical sensing with smartphones. Nano Convergence (2018)
Mahato, K., Purohit, B., Kumar, A., Chandra, P.: Paper-based biosensors for clinical and biomedical applications: emerging engineering concepts and challenges. Compr. Anal.Chem. (2020)
Duque, T., Chaves Ribeiro, A.C., de Camargo, H.S., Costa Filho, P.A., da Mesquita Cavalcante, H.P., Lopes, D.: New insights on optical biosensors: techniques, construction and application. State of the Art in Biosensors—General Aspects [Internet]. (2013), InTech, https://doi.org/10.5772/52330
Hussain, S.A., Dey, D., Chakraborty, S., Saha, J., Roy, A.D., Chakraborty, S., et al.: Fluorescence resonance energy transfer (FRET) sensor. BMC Pharmacology [Internet]. 8(S1), (2014) Springer Nature, Aug 26 http://arxiv.org/abs/1408.6559
Zhang, J., Shikha, S., Mei, Q., Liu, J., Zhang, Y.: Fluorescent microbeads for point-of-care testing: a review. Microchim. Acta (2019a)
Raja, S., Ching, J., Xi, L., Hughes, S.J., Chang, R., Wong, W., et al.: Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing. Clin. Chem. 51(5), (2005)
Hochreiter, B., Garcia, A.P., Schmid, J.A.: Fluorescent proteins as genetically encoded FRET biosensors in life sciences [Internet]. Sensors (Switzerland). 26281–26314 (2015). MDPI AG, /pmc/articles/PMC4634415/?report=abstract
A., S.J., C P.L: Existing and emerging technologies for point-of-care testing—PubMed [Internet]. https://pubmed.ncbi.nlm.nih.gov/25336761/
D’Auria, S., Ghirlanda, G., Parracino, A., de Champdoré, M., Scognamiglio, V., Staiano, M., et al.: Fluorescence biosensors for continuously monitoring the blood glucose level of diabetic patients. Glucose Sensing. [Internet]. pp. 117–130, Springer, US (2006) https://doi.org/10.1007/0-387-33015-1_5
Hartman, M.R., Ruiz, R.C.H., Hamada, S., Xu, C., Yancey, K.G., Yu, Y., et al.: Point-of-care nucleic acid detection using nanotechnology. Nanoscale [Internet]. 5(21), 10141–54 (2013). The Royal Society of Chemistry, https://pubs.rsc.org/en/content/articlehtml/2013/nr/c3nr04015a
Radiometer.: Analyseur d’immunodosage AQT90 FLEX—Radiometer [Internet]. https://www.radiometer.fr/fr-fr/produits/analyseur-d’immunodosage/analyseur-dimmunodosage-aqt90-flex
Serra, P.A.: Biosensors for health, environment and biosecurity [Internet]. InTech, [cited 9 Nov 2020]. https://www.intechopen.com/books/biosensors-for-health-environment-and-biosecurity (2012)
Taguchi, M., Ptitsyn, A., McLamore, E.S., Claussen, J.C.: Nanomaterial-mediated biosensors for monitoring glucose [Internet]. J. Diabetes Sci. Technol. 403–411 (2014). Diabetes Technology Society, /pmc/articles/PMC4455391/?report=abstract
Geldert, A., Kenry, Lim, C.T.: Paper-based MoS2 nanosheet-mediated FRET aptasensor for rapid malaria diagnosis. Sci. Rep. [Internet]. 7(1) (2017) Nature Publishing Group,https://pubmed.ncbi.nlm.nih.gov/29235484/
Zhang, X., Hashem, M.A., Chen, X., Tan, H.: On passing a non-Newtonian circulating tumor cell (CTC) through a deformation-based microfluidic chip. Theor. Comput. Fluid Dyn. [Internet]. 32(6), 753–764 (2018). Springer New York LLC, https://ui.adsabs.harvard.edu/abs/2018ThCFD..32..753Z/abstract
Khan, R., Khurshid, Z., Yahya Ibrahim Asiri, F.: Advancing point-of-care (PoC) testing using human saliva as liquid biopsy. Diagnostics (2017)
Shin, Y., Kim, J., Lee, T.Y.: A solid phase-bridge based DNA amplification technique with fluorescence signal enhancement for detection of cancer biomarkers. Sens. Actuators B Chem. (2014)
Kosaka, P.M., Pini, V., Calleja, M., Tamayo, J.: Ultrasensitive detection of HIV-1 p24 antigen by a hybrid nanomechanical-optoplasmonic platform with potential for detecting HIV-1 at first week after infection. PLoS ONE (2017)
Girigoswami, K., Akhtar, N.: Nanobiosensors and fluorescence based biosensors: an overview. Int. J. Nano Dimension (2019)
Tokel, O., Inci, F., Demirci, U.: Advances in plasmonic technologies for point of care applications. Chem. Rev. 114(11), 5728–5752 (2014)
Förster, T.: Zwischenmolekulare Energiewanderung und Fluoreszenz. Annalen der Physik. (1948)
Zadran, S., Standley, S., Wong, K., Otiniano, E., Amighi, A., Baudry, M.: Fluorescence resonance energy transfer (FRET)-based biosensors: visualizing cellular dynamics and bioenergetics [Internet]. Applied Microbiology and Biotechnology. Appl. Microbiol. Biotechnol. 895–902 (2012) https://pubmed.ncbi.nlm.nih.gov/23053099/
Zhang, X., Hu, Y., Yang, X., Tang, Y., Han, S., Kang, A., et al.: FÖrster resonance energy transfer (FRET)-based biosensors for biological applications [Internet]. Biosens. Bioelectron. (2019c). Elsevier Ltd, https://pubmed.ncbi.nlm.nih.gov/31096114/
Hellenkamp, B., Schmid, S., Doroshenko, O., Opanasyuk, O., Kühnemuth, R., Rezaei Adariani, S., et al.: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study. Nat. Methods (2018)
Sandbhor Gaikwad, P., Banerjee, R.: Advances in point-of-care diagnostic devices in cancers. Analyst (2018)
Zhang, J., Shikha, S., Mei, Q., Liu, J., Zhang, Y.: Fluorescent microbeads for point-of-care testing: a review. Microchim. Acta (2019b)
Qiu, X., Hildebrandt, N.: A clinical role for Förster resonance energy transfer in molecular diagnostics of disease [Internet]. Expert Rev. Mol Diagn. 767–771 (2019) Taylor and Francis Ltd, https://doi.org/10.1080/14737159.2019.1649144
van der Fels-Klerx, H.J., van Asselt, E.D., Raley, M., Poulsen, M., Korsgaard, H., Bredsdorff, L., et al.: Critical review of methods for risk ranking of food-related hazards, based on risks for human health. Critical Rev. Food Sci Nutr. (2018)
Choi, J.R., Yong, K.W., Choi, J.Y., Cowie, A.C.: Emerging point-of-care technologies for food safety analysis. Sensors (Switzerland) (2019)
Morales-Narváez, E., Naghdi, T., Zor, E., Merkoçi, A.: Photoluminescent lateral-flow immunoassay revealed by graphene oxide: highly sensitive paper-based pathogen detection. Anal. Chem. (2015)
Zhang, Y., Zuo, P., Ye, B.C.: A low-cost and simple paper-based microfluidic device for simultaneous multiplex determination of different types of chemical contaminants in food. Biosens. Bioelectron. (2015)
Mei, Q., Jing, H., Li, Y., Yisibashaer, W., Chen, J., Nan Li, B., et al.: Smartphone based visual and quantitative assays on upconversional paper sensor. Biosens. Bioelectron. (2016)
Petryayeva, E., Algar, W.R.: Multiplexed homogeneous assays of proteolytic activity using a smartphone and quantum dots. Anal. Chem. (2014)
Mizutani, T., Kondo, T., Darmanin, S., Tsuda, M., Tanaka, S., Tobiume, M., et al.: A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells. Clin. Cancer Res. 16(15), 3964–3975 (2010)
Lu, S., Wang, Y.: Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy. Clin. Cancer Res. (2010)
Carrascosa, L.G., Huertas, C.S., Lechuga, L.M.: Prospects of optical biosensors for emerging label-free RNA analysis. Trac, Trends Anal. Chem. (2016)
Ermini, M.L., Mariani, S., Scarano, S., Minunni, M.: Bioanalytical approaches for the detection of single nucleotide polymorphisms by Surface Plasmon Resonance biosensors [Internet]. Biosens. Bioelectron. 28–37 (2014). Elsevier Ltd, https://pubmed.ncbi.nlm.nih.gov/24841091/
González-Guerrero, A.B., Maldonado, J., Herranz, S., Lechuga, L.M.: Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics [Internet]. Anal. Methods. 8380–8394 (2016) Royal Society of Chemistry, https://pubs.rsc.org/en/content/articlehtml/2016/ay/c6ay02972h
Huertas, C.S., Calvo-Lozano, O., Mitchell, A., Lechuga, L.M.: Advanced evanescent-wave optical biosensors for the detection of nucleic acids: an analytic perspective. Front. Chem. (2019b)
Ahn, H., Song, H., Choi, J.R., Kim, K.: A localized surface plasmon resonance sensor using double-metal-complex nanostructures and a review of recent approaches. Sensors (Switzerland) 18(1) (2018)
Harpaz, D., Koh, B., Marks, R.S., Seet, R.C.S., Abdulhalim, I., Tok, A.I.Y.: A functionalized gold chip with specific antibody. pp. 1–16, (2019)
Tang, Y., Zeng, X., Liang, J.: Surface plasmon resonance: an introduction to a surface spectroscopy technique. J. Chem. Edu. (2010)
Endo, T., Kerman, K., Nagatani, N., Takamura, Y., Tamiya, E.: Label-free detection of peptide nucleic acid-DNA hybridization using localized surface plasmon resonance based optical biosensor. Anal. Chem. [Internet]. 77(21), 6976–6984 (2005). American Chemical Society, https://doi.org/10.1021/ac0513459
Mayer, K.M., Hafner, J.H.: Localized surface plasmon resonance sensors. Chem. Rev. (2011)
Park, K.H., Kim, S., Yang, S.M., Park, H.G.: Detection of DNA immobilization and hybridization on gold/silver nanostructures using localized surface plasmon resonance. J. Nanosci. Nanotechnol. [Internet]. 1374–1378 (2009) https://pubmed.ncbi.nlm.nih.gov/19441528/
Roether, J., Chu, K.Y., Willenbacher, N., Shen, A.Q., Bhalla, N.: Real-time monitoring of DNA immobilization and detection of DNA polymerase activity by a microfluidic nanoplasmonic platform. Biosens. Bioelectron. (2019)
Bhalla N, Sathish S, Sinha A, Shen AQ. Large-Scale Nanophotonic Structures for Long-Term Monitoring of Cell Proliferation. Adv. Biosyst. [Internet]. 2(4), 1700258 (2018), Wiley, [cited 10 Nov 2020]. https://doi.org/10.1002/adbi.201700258
Huang, C., Ye, J., Wang, S., Stakenborg, T., Lagae, L.: Gold nanoring as a sensitive plasmonic biosensor for on-chip DNA detection. Appl. Phy. Lett. [Internet]. 100(17), 173114 (2012). American Institute of PhysicsAIP, https://doi.org/10.1063/1.4707382
Schneider, T., Jahr, N., Jatschka, J., Csaki, A., Stranik, O., Fritzsche, W.: Localized surface plasmon resonance (LSPR) study of DNA hybridization at single nanoparticle transducers. J. Nanopart. Res. [Internet]. 15(4), 1–10 (2013) Springer, https://doi.org/10.1007/s11051-013-1531-7
Sun, L.L., Leo, Y.S., Zhou, X., Ng, W., Wong, T.I., Deng, J.: Localized surface plasmon resonance based point-of-care system for sepsis diagnosis. Mater. Sci. Energy Technol. 3, 274–281 (2020). Elsevier BV
Steiner, G.: Surface plasmon resonance imaging. Anal. Bioanal. Chem. [Internet]. Anal. Bioanal. Chem. [cited 10 Nov 2020], 379(3), 328–331 (2004). https://pubmed.ncbi.nlm.nih.gov/15127177/
Homola, J.: Surface plasmon resonance sensors for detection of chemical and biological species [Internet]. Chem. Rev. American Chemical Society. 462–493 (2008) https://doi.org/10.1021/cr068107d
Campbell, C.T., Kim, G.: SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics. Biomaterials (2007)
Fu, E., Foley, J., Yager, P.: Wavelength-tunable surface plasmon resonance microscope. Rev. Sci. Instrum. [Internet]. 74(6):3182–3184 (2003). American Institute of Physics AIP, https://doi.org/10.1063/1.1574603
Shumaker-Parry, J.S., Campbell, C.T.: Quantitative methods for spatially resolved adsorption/desorption measurements in real time by surface plasmon resonance microscopy. Anal. Chem. [Internet]. American Chemical Society, Feb 15,76(4), 907–917 (2004) https://doi.org/10.1021/ac034962a
Wang D, Loo JFC, Chen J, Yam Y, Chen SC, He H, et al. Recent advances in surface plasmon resonance imaging sensors. Sensors (Switzerland) (2019)
Jordan, C.E., Com, R.M.: Surface plasmon resonance imaging measurements of electrostatic biopolymer adsorption onto chemically modified gold surfaces. Anal. Chem. (1997)
Nelson, B.P., Grimsrud, T.E., Liles, M.R., Goodman, R.M., Corn, R.M.: Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays. Anal. Chem. (2001)
Wegner, G.J., Lee, H.J., Corn, R.M.: Characterization and optimization of peptide arrays for the study of epitope-antibody interactions using surface plasmon resonance imaging. Anal. Chem. (2002)
Liu, Y., Liu, Q., Chen, S., Cheng, F., Wang. H., Peng, W.: Surface plasmon resonance biosensor based on smart phone platforms. Sci. Rep. (2015b)
Ho, H.P., Huang, Y.H., Wu, S.Y., Kong, S.K.: Detecting phase shifts in surface plasmon resonance: a review. Adv. Opt. Technol. (2012)
Lee, K.H., Su, Y.D., Chen, S.J., Tseng, F.G., bin Lee, G.: Microfluidic systems integrated with two-dimensional surface plasmon resonance phase imaging systems for microarray immunoassay. Biosens. Bioelectron. (2007)
Wang, D., Ding, L., Zhang, W., Luo, Z., Ou, H., Zhang, E., et al.: A high-throughput surface plasmon resonance biosensor based on differential interferometric imaging. Measur. Sci. Technol. [Internet]. Institute of Physics Publishing, 2012 May 4, 23(6), 065701. https://doi.org/10.1088/0957-0233/23/6/065701
Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., Fabris, L.: A review on surface-enhanced Raman scattering. Biosensors (2019)
Huang, C.C., Cheng, C.Y., Lai, Y.S.: Paper-based flexible surface enhanced Raman scattering platforms and their applications to food safety. Trends. Food Sci. Technol. (2020)
Lee, C.H., Tian, L., Singamaneni, S.: Paper-based SERS swab for rapid trace detection on real-world surfaces. ACS Appl. Mater. Interfaces (2010)
Liu, X., Wang, J., Tang, L., Xie, L., Ying, Y.: Flexible plasmonic metasurfaces with user-designed patterns for molecular sensing and cryptography. Adv. Funct. Mater. (2016)
Park, M., Jung, H., Jeong, Y., Jeong, K.H.: Plasmonic schirmer strip for human tear-based gouty arthritis diagnosis using surface-enhanced Raman scattering. ACS Nano (2017)
Qiu, H., Wang, M., Jiang, S., Zhang, L., Yang, Z., Li, L., et al.: Reliable molecular trace-detection based on flexible SERS substrate of graphene/Ag-nanoflowers/PMMA. Sens. Actuators B Chem. (2017)
Xu, K., Zhou, R., Takei, K., Hong, M.: Toward flexible surface-enhanced raman scattering (SERS) sensors for point-of-care diagnostics. Adv. Sci. (2019)
Martens, D., Bienstman, P.: Study on the limit of detection in MZI-based biosensor systems. Sci. Rep. 9(1), 1–8 (2019)
Tian, L., Jiang, Q., Liu, K.K., Luan, J., Naik, R.R., Singamaneni, S.: Bacterial nanocellulose-based flexible surface enhanced raman scattering substrate. Adv. Mater. Interfaces (2016)
Rajan, Chand S, Gupta, B.D.: Fabrication and characterization of a surface plasmon resonance based fiber-optic sensor for bittering component-Naringin. Sens Actuators B Chem. (2006)
Sharma, A.K., Gupta, B.D.: On the sensitivity and signal to noise ratio of a step-index fiber optic surface plasmon resonance sensor with bimetallic layers. Opt. Commun. (2005)
Zanchetta, G., Lanfranco, R., Giavazzi, F., Bellini, T., Buscaglia, M.: Emerging applications of label-free optical biosensors. Nanophotonics (2017)
Sharma, A.K., Gupta, B.D.: Absorption-based fiber optic surface plasmon resonance sensor: a theoretical evaluation. Sens. Actuators B Chem. (2004)
Slavík, R., Homola, J., Tyroký, J., Brynda, E.: Novel spectral fiber optic sensor based on surface plasmon resonance. Sens. Actuators B Chem. (2001)
Gupta, B.D., Verma, R.K.: Surface plasmon resonance-based fiber optic sensors: principle, probe designs, and some applications. J. Sens. (2009)
Liu, Q., Yuan, H., Liu, Y., Wang, J.: Real-time biodetection using a smartphone-based dual-color surface plasmon resonance sensor. J. Biomed. Opt. (2018)
John, S.: Strong localization of photons in certain disordered dielectric superlattices. Phys. Rev Lett. (1987)
Yablonovitch, E.: Inhibited spontaneous emission in solid-state physics and electronics. Phys. Rev. Lett. (1987)
Dinish, U.S., Fu, C.Y., Soh, K.S., Ramaswamy, B., Kumar, A., Olivo, M.: Highly sensitive SERS detection of cancer proteins in low sample volume using hollow core photonic crystal fiber. Biosens. Bioelectron. (2012)
Dorfner, D., Zabel, T., Hürlimann, T., Hauke, N., Frandsen, L., Rant, U., et al.: Photonic crystal nanostructures for optical biosensing applications. Biosens. Bioelectron. (2009)
Scullion, M.G., di Falco, A., Krauss, T.F.: Slotted photonic crystal cavities with integrated microfluidics for biosensing applications. Biosens. Bioelectron. (2011)
Zinoviev, K., Carrascosa, L.G., del Río, J.S., Sepúlveda, B., Domínguez, C., Lechuga, L.M.: Silicon photonic biosensors for lab-on-a-chip applications. Adv. Opt. Technol. (2008)
Scott, A., Florjańczyk, M., Cheben, P., Janz, S., Solheim, B., Xu, D.-X:. Micro-interferometer with high throughput for remote sensing. In: Dickensheets, D.L., Schenk, H., Piyawattanametha, W., (eds.) MOEMS and Miniaturized Systems VIII [Internet]. SPIE; 2009 p. 72080G. https://doi.org/10.1117/12.808271
Liu, Q., Shin, Y., Kee, J.S., Kim, K.W., Mohamed Rafei, S.R., Perera, A.P., et al.: Mach-Zehnder interferometer (MZI) point-of-care system for rapid multiplexed detection of microRNAs in human urine specimens. Biosens. Bioelectron. (2015a)
Bastos, A.R., Vicente, C.M.S., Oliveira-Silva, R., Silva, N.J.O., Tacão, M., da Costa, J.P., et al.: Integrated optical Mach-Zehnder interferometer based on organic-inorganic hybrids for photonics-on-a-chip biosensing applications. Sensors (Switzerland) (2018)
Gauglitz, G.: Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects. Anal. Bioanal. Chem. (2020)
Kussrow, A., Enders, C.S., Bornhop, D.J.: Interferometric methods for label-free molecular interaction studies. Anal. Chem. (2012)
Liang, Y., Zhao, M., Wu, Z., Morthier, G.: Bimodal waveguide interferometer RI sensor fabricated on low-cost polymer platform. IEEE Photonics J. (2019)
Duval, D., González-Guerrero, A.B., Dante, S., Osmond, J., Monge, R., Fernández, L.J., et al.: Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers. Lab Chip (2012)
Herranz, S., Gavela, A.F., Lechuga, L.M.: Label-free biosensors based on bimodal waveguide (BiMW) interferometers. Methods Mol. Biol. (2017)
Zinoviev, K.E., González-Guerrero, A.B., Domínguez, C., Lechuga, L.M.: Integrated bimodal waveguide interferometric biosensor for label-free analysis. J. Lightwave Technol. (2011)
Konwar, A.N., Borse, V.: Current status of point-of-care diagnostic devices in the Indian healthcare system with an update on COVID-19 pandemic. Sens. Int. (2020b)
Zhang, C.Y., Yeh, H.C., Kuroki, M.T., Wang, T.H.: Single-quantum-dot-based DNA nanosensor. Nat. Mater. (2005)
Zeni, L., Perri, C., Cennamo, N., Arcadio, F., D’Agostino, G., Salmona, M., et al.: A portable optical-fibre-based surface plasmon resonance biosensor for the detection of therapeutic antibodies in human serum. Sci. Rep. (2020)
Arunya Revathi, A., Rajeswari, D.: Surface plasmon resonance biosensor-based dual-core photonic crystal fiber: design and analysis. J. Opt. (India) [Internet]. 49(2), 163–167, (2020), Springer, https://doi.org/10.1007/s12596-020-00600-y
Eom, H., Kim, J.H., Hur, J., Kim, T.S., Sung, S.K., Choi, J.H., et al.: Nanotextured polymer substrate for flexible and mechanically robust metal electrodes by nanoimprint lithography. ACS Appl. Mater. Interfaces (2015)
Jiang, J., Zou, S., Ma, L., Wang, S., Liao, J., Zhang, Z.: Surface-enhanced raman scattering detection of pesticide residues using transparent adhesive tapes and coated silver nanorods. ACS Appl. Mater. Interfaces (2018)
Mungroo, N.A., Neethirajan, S.: Biosensors for the detection of antibiotics in poultry industry-a Review. Biosensors (2014)
Shu, Y., Tian, H., Yang, Y., Li, C., Cui, Y., Mi, W., et al.: Surface-modified piezoresistive nanocomposite flexible pressure sensors with high sensitivity and wide linearity. Nanoscale (2015)
Singh, J.P., Chu, H., Abell, J., Tripp, R.A., Zhao, Y.: Flexible and mechanical strain resistant large area SERS active substrates. Nanoscale (2012)
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Joseph, V.E., Ramadoss, A. (2022). Optical Biosensors Towards Point of Care Testing of Various Biochemicals. In: Joshi, S.N., Chandra, P. (eds) Advanced Micro- and Nano-manufacturing Technologies. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-3645-5_11
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