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Nanosystems for Cancer Therapy

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Bio-Nano Interface

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Abstract

The chapter focuses on the various nanosystems and their applications in cancer therapy. The nanosystems comprise nanoscaled biomaterials that carry the drug molecules, proteins and genes into the tumor environment to achieve therapeutic efficacy. The current know-how of the cancer physiology and the cancer milieu facilitates designing nanosystems for cancer therapy. In terms of size, nanosystems are a thousandth part of an average human cell. Nanosystems having a size of less than 300 nm have enhanced permeability and retention in cancer cells than healthy cells.

In comparison, nanosystems less than 50 nm in size easily enter most of the healthy cells. Hence, the size of nanosystems is extremely critical for their enhanced efficacy. By exploiting their small size, nanosystems can interact with physiological molecules both outside and inside the cancer cells. Upon functionalization of nanoparticles with antibodies, drug molecules, and genes, we can have access to all the cells of the body. The system behaves like inject and forget nanodevice which can selectively target cancer cells without affecting normal cells. The nanosystems are building the roadmap for future technologies where these can be potentially used to detect cancer cells and deliver treatment at the targeted site.

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Authors and Affiliations

  1. Department of Pharmacology, Nirmala College of Pharmacy, Atmakur Road, Mangalagiri, Guntur, Andhra Pradesh, India

    Sailendra Kumar Mahanta

  2. Center for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, India

    Manoranjan Arakha

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  1. Sailendra Kumar Mahanta
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Editors and Affiliations

  1. Centre for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

    Manoranjan Arakha

  2. Centre for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

    Arun Kumar Pradhan

  3. Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India

    Suman Jha

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Mahanta, S.K., Arakha, M. (2022). Nanosystems for Cancer Therapy. In: Arakha, M., Pradhan, A.K., Jha, S. (eds) Bio-Nano Interface. Springer, Singapore. https://doi.org/10.1007/978-981-16-2516-9_8

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