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Redox Signaling

Hallmarks of Cancer Progression and Resistance to Treatment

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

A diverse redox microenvironment exists in healthy cells and cancer cells. Homeostasis of the redox microenvironment of a healthy cell is severely deregulated in cancer pathogenesis. The loss and gain of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have a detrimental effect on cellular physiology. Cancer cells are unique for reprogramming and reorganizing the metabolic circuitries and redox signaling to sustain their high proliferation rate, progression, and metastasis. Recent evidence suggested that oxidative stress-induced signaling plays an essential role in the invasion of cancer cells through extracellular matrix (ECM). The dysregulation of ROS generation in the tumor microenvironment affects the extravasation, intravasation, and colonization of target organs by cancer cells during their migration via the interstitial matrix and basement membrane. The present chapter outlines the redox regulation of ECM involved in cancer progression during oxidative stress. We have discussed the pivotal role of the redox system in the remodeling of cytoskeleton, cell–cell junctions, and cell mobility during cancer progression. The contribution of mitochondria in regulating the interplay between redox homeostasis and metabolism within tumor cells is highlighted. We have described the contribution of altered redox signaling in cancer progression and the development of drug resistance in cancer therapies. The epithelial–mesenchymal transition (EMT), the driving force of cancer cell metastasis and drug resistance, is also explored. A better understanding of the redox signaling pathways in cancer progression and cancer treatment resistance might enable us to use novel strategies for therapeutic intervention.

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Authors and Affiliations

  1. Department of Molecular Biology & Bioinformatics, Tripura University (A Central University), Agartala, Tripura, India

    Surajit Bhattacharjee, Suman Paul & Chandan RayBarman

Authors
  1. Surajit Bhattacharjee
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  2. Suman Paul
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  3. Chandan RayBarman
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Corresponding author

Correspondence to Surajit Bhattacharjee .

Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Chair and Department of Toxicology, Jagiellonian University Collegium Medicum, Kraków, Poland

    Maria Walczak

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

    Pulak Kar

  4. University of Burdwan, Bardhaman, West Bengal, India

    Somasri Dam

  5. Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland

    Kuntal Dey

  6. Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA

    Muthusamy Kunnimalaiyaan

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Bhattacharjee, S., Paul, S., RayBarman, C. (2022). Redox Signaling. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_152-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_152-1

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  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

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