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Deciphering the Role of Epigenetic Reprogramming in Host-Pathogen Interactions

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Integrated Omics Approaches to Infectious Diseases

Abstract

The success of a pathogen within the host depends on various extrinsic factors that work in a synergistic mechanism to promote pathogenesis. One such factor is driven by the changes observed within the host genome, providing survival and establishment of pathogens inside the host. Pathogens are also known for establishing their intracellular niche within the host by mimicking the host enzymes and immune system for survival. Understanding the strategies used by pathogens to intervene in host genetic machinery for pathogenesis is important for creating successful targets and personalized drugs to counterbalance their effects. Accumulation of omics data and simultaneous development of bioinformatics analysis tools have allowed researchers to understand the interplay between prokaryotic and eukaryotic cells through the multi-omics approach. This permits a better understanding of diseases associated with host-parasite interactions and subsequent development of personalized medicines as therapeutics.

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Acknowledgment

AKK would like to acknowledge the UGC, Government of India for SRF. UD is supported by the SERB-DST grant (ECR/2017/000605).

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Authors and Affiliations

  1. Department of Biomedical Science, Bhaskaracharya College of Applied Sciences, University of Delhi, New Delhi, India

    Amandeep Kaur Kang & Uma Dhawan

  2. School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India

    Andrew M. Lynn

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  1. Amandeep Kaur Kang
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  1. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Haryana, India

    Saif Hameed

  2. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Haryana, India

    Zeeshan Fatima

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Kang, A.K., Lynn, A.M., Dhawan, U. (2021). Deciphering the Role of Epigenetic Reprogramming in Host-Pathogen Interactions. In: Hameed, S., Fatima, Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_3

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