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Pathogenesis of Staphylococcus aureus and Proteomic Strategies for the Identification of Drug Targets

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Abstract

Staphylococcus aureus is a leading pathogen responsible for mild to severe invasive infections in humans. Especially, methicillin-resistant Staphylococcus aureus (MRSA) is prevalent in hospital settings and biomaterial-associated infections. In addition, MRSA is listed as high-priority pathogen in WHO priority pathogen list and occupied the serious threat level in CDC’s drug-resistant bacteria report. Persistent S. aureus infections are often associated with biofilm formation and resistant to conventional antimicrobial therapy. Inhibiting the surface adherence and virulence of the bacterium is the current alternative approach without affecting growth to reduce the possibility of resistance development. Though numerous antibiofilm agents have been identified, their mode of action remains unclear. Proteomics is the powerful approach to delineate the drug targets of bioactive molecules. Bottom-up strategy-based comparative proteomics is extensively used in the field of disease diagnosis and therapy. Molecular targets of antibiotics and antibiofilm agents active against S. aureus have been unveiled using various proteomic approaches and lead to development of drug discovery as well.

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Acknowledgment

The authors sincerely acknowledge DST-FIST [Grant No. SR/FST/LSI-639/2015(C)], UGC-SAP [Grant No. F.5-1/2018/DRS-II(SAP-II)] and DST-PURSE [Grant No. SR/PURSE Phase 2/38 (G)] for providing instrumentation facilities. The authors also thank RUSA 2.0 [F.24-51/2014-U, Policy (TN Multi-Gen), Dept. of Edn, GoI], and SKP is thankful to UGC for Mid-Career Award [F.19-225/2018(BSR)].

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All the authors declare no conflict of interest.

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  1. Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India

    Alaguvel Valliammai, Anthonymuthu Selvaraj & Shunmugiah Karutha Pandian

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  1. Alaguvel Valliammai
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  1. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Haryana, India

    Saif Hameed

  2. Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Haryana, India

    Zeeshan Fatima

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Valliammai, A., Selvaraj, A., Pandian, S.K. (2021). Pathogenesis of Staphylococcus aureus and Proteomic Strategies for the Identification of Drug Targets. In: Hameed, S., Fatima, Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_18

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