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Oral Cancer and Oxidative Stress

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Oral squamous cell carcinoma (OSCC) is one of the common forms of oral cancer associated with significant morbidity and mortality. Over several years, attempts have been made to understand the mechanism of oral carcinogenesis with an intention for early diagnosis and implementation of appropriate therapeutic strategies. OSCC is generally characterized by a complex interplay of environment and genetic factors resulting in its initiation, promotion, and subsequent progression. Etiological factors such as tobacco, smoking, and viruses along with genetic and epigenetic factors are the major contributors of oral carcinomas. Oxidative stress is a general term used to indicate the imbalance associated with either an increased reactive oxygen species or deficient antioxidant defense mechanisms or both. While literature evidence suggests a causal role of oxidative stress in oral carcinogenesis, the effect of oxidative stress and the antioxidants on oral carcinogenesis is still unclear. The purpose of this chapter is to discuss the various effects of oxidative stress on OSCC and enable the understanding of its potential role in oral carcinogenesis.

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Author information

Authors and Affiliations

  1. Department of Oral Pathology and Microbiology, Dr. G. D. Pol Foundation YMT Dental College and Hospital, Navi Mumbai, India

    Gokul Sridharan

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  1. Gokul Sridharan
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Sridharan, G. (2022). Oral Cancer and Oxidative Stress. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_7

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