Abstract
Oxidative stress has been implicated in a variety of diseases including initiation and progression of cancer. This review will focus on the role of oxidative stress in breast cancer with specific focus on mitochondrial metabolism and mitochondria-derived oxidative stress that affects the breast cancer microenvironment. The review will detail the significant effects of oxidative stress on components of the stroma that in turn plays a critical role in communications with cancer cells, thereby promoting breast cancer cell alterations and progression to solid tumors. Three specific sections will cover (1) The role of mitochondrial metabolism in breast cancer development and progression with focus on mitochondria and ROS production; (2) The breast tumor microenvironment, metabolic interactions and crosstalk between stroma and tumor cells; (3) Oxidative stress as an essential factor in the pathogenesis and progression of breast cancer.
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Schatten, H. (2022). Mitochondrial Metabolism, Oxidative Stress, and the Microenvironment in Breast Cancer Development and Progression. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_56
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DOI: https://doi.org/10.1007/978-981-15-9411-3_56
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