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Targeting Oxidative Stress in Cancer

Opportunity for Natural and Synthetic Compounds, and Cancer Stem Cell Therapy

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Abstract

Oxidative stress plays an immense role in modulating all aspects of cancer and also correlated with the different types of carcinogenesis in the form of tumor-bearing state in the different organs as well as treatment strategy to counteract with the carcinogenesis. The oxidative stress arises from exogenous origins, i.e., ultraviolet rays as well as endogenous origins at the cellular level with the involvement of mitochondria. Modifications of the oxidative stress producing indices trigger gene mutations with alteration of the intracellular signal transduction and transcription leading to carcinogenesis. It also initiates the cellular systems into tumor bearing state with active oxygen production by tumor cells as well as abnormal oxidation-reduction control in the system. Anticancer agents and radiation therapy are beneficial to exert their effects through apoptosis of different cancer cells. Modulation of reactive oxygen species (ROS) is highly significant for cancer therapy because commonly used radio- and chemotherapeutic drugs influence tumor outcome through ROS modulation. In addition, natural compounds, synthetic compounds, and cancer stem cell therapy also play a vital role in modulating oxidative stress and preventing progression of the carcinogenesis. Therefore, these three types of treatment strategy would be the novel biomarkers to forecast the clinical responses through prooxidant therapies of the cancer patients.

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Acknowledgment

The authors acknowledge Department of Zoology, The University of Burdwan.

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Authors and Affiliations

  1. Biomedical Genetics Laboratory, Department of Zoology, The University of Burdwan, Bardhaman, West Bengal, India

    Paramita Mandal, Anindita Goswami, Sarmistha Adhikari & Subham Sarkar

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  1. Paramita Mandal
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  2. Anindita Goswami
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  3. Sarmistha Adhikari
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  4. Subham Sarkar
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Mandal, P., Goswami, A., Adhikari, S., Sarkar, S. (2022). Targeting Oxidative Stress in Cancer. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_19

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