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Modulation of JAK/STAT Pathways in Cancer by Phytochemicals

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Cancer remains a global major health burden. Activation of certain signaling pathways such as Janus kinase (JAK)/signal transducer and activator of transcription (STAT) is found to be an important regulatory defect present in most cancerous cells amongst other factors. The signaling of Cytokine causes the activation of “STAT proteins” in regulating the proliferation and differentiation of cells, more so its role in the modulation of targeted genes cannot be over emphasized. Phytochemicals play significant role in the inhibition of the JAK/STAT signaling in antigen-presenting cells by targeting different pathways. In this review, Resveratrol, cucurbitacin, curcumin, Epigallocatechin-3-gallate and others are promising phytochemicals discussed. Extensive studies have now shown that phytochemicals perform crucial functions in inhibiting the multiplication and proliferation of cancerous cell thus providing novel channels for targeting cancer therapeutically.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

    Olorunfemi R. Molehin, Ajibade O. Oyeyemi & Oluwatumininu O. Adesua

  2. Bioinformatics and Molecular Biology Unit, Department of Biochemistry, Federal University of Technology Akure, Akure, Nigeria

    Olusola O. Elekofehinti

  3. Na Moda Naturals, Federal Housing Estate, Ibadan, Nigeria

    Oluwatosin B. Olusakin

  4. Department of Biochemistry and Molecular Biology, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Nigeria

    Aderonke E. Fakayode

  5. Department of Pharmacology and Therapeutics, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria

    Ezekiel T. Ige

Authors
  1. Olorunfemi R. Molehin
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  2. Olusola O. Elekofehinti
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  3. Ajibade O. Oyeyemi
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  4. Oluwatosin B. Olusakin
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  5. Aderonke E. Fakayode
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  6. Ezekiel T. Ige
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  7. Oluwatumininu O. Adesua
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Corresponding author

Correspondence to Olorunfemi R. Molehin .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA

    Bimal K Ray

  3. Saroj Gupta Cancer Centre & Research Ins, Kolkata, India

    Sushanta Roychowdhury

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Molehin, O.R. et al. (2021). Modulation of JAK/STAT Pathways in Cancer by Phytochemicals. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_88-1

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  • DOI: https://doi.org/10.1007/978-981-15-4501-6_88-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4501-6

  • Online ISBN: 978-981-15-4501-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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