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Association of Oxidative Stress and Mitochondrial Dysfunction to Gynecological Malignancies

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Abstract

Despite years of concerted research, gynecological malignancies have remained a persistent cause of morbidity and mortality in females across the globe. Nearly asymptomatic initial phases render gynecological cancers difficult to be diagnosed during the early stages, further complicating scopes for therapeutic intervention and disease combat. Based on several studies and advancements, oxidative stress has emerged as a prime regulator of myriad events contributing to cancer progression. The mitochondrion is the major site for intrinsic oxidative stress generation, whereas extrinsic factors include UV irradiation, alcohol, pollutants, etc. The manifestation of oxidative stress-induced cancer progression is through different reactive species of which the reactive oxygen species (ROS) is the most abundant. ROS functions as the key regulator of REDOX imbalance, and the underlying oncogenic events, as per reports, exert dual role by exhibiting both tumor suppressing and tumor promoting functions. Low levels of ROS mainly exert cytotoxic effects on tumor cells, whereas fairly increased ROS levels contribute to cancer progression majorly by remodeling the microenvironment niche, rewiring the cellular bioenergetics, and altering the signaling events. The intricacies of ROS imbalance and the paradigm of its functional relevance in gynecological cancer progression cumulatively emphasize on the need for the understanding of the detailed mechanism therein. This chapter aims at underlining different aspects of mitochondrial dysfunction and oxidative stress that promote oncogenesis, intending to pave ways for newer and effective therapeutic interventions.

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Authors and Affiliations

  1. Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Deepshikha Ghosh, Priti Chatterjee, Tulika Mitra & Sib Sankar Roy

  2. Academy of Scientific and Innovative Research, CSIR- Indian Institute of Chemical Biology Campus, Kolkata, India

    Sib Sankar Roy

  3. Department of Biochemistry, School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India

    Tulika Mitra

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  1. Deepshikha Ghosh
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  2. Priti Chatterjee
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  3. Tulika Mitra
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  4. Sib Sankar Roy
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Correspondence to Sib Sankar Roy .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA

    Bimal K Ray

  3. Saroj Gupta Cancer Centre & Research Ins, Kolkata, India

    Sushanta Roychowdhury

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Ghosh, D., Chatterjee, P., Mitra, T., Roy, S.S. (2021). Association of Oxidative Stress and Mitochondrial Dysfunction to Gynecological Malignancies. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_15-1

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  • DOI: https://doi.org/10.1007/978-981-15-4501-6_15-1

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  • Print ISBN: 978-981-15-4501-6

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