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Immune Recognition of Pathogen-Derived Glycolipids Through Mincle

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Lectin in Host Defense Against Microbial Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1204))

Abstract

Mincle (macrophage inducible C-type lectin, Clec4e, Clecsf9) was originally identified as a member of the C-type lectin receptor family in 1999. Then, the function of Mincle to control antifungal immunity by binding to Candida albicans was reported in 2008. Around the same time, it was reported that Mincle recognized damaged cells and induced sterile inflammation by coupling with the ITAM-adaptor molecule FcRγ. In the following year, a breakthrough discovery reported that Mincle was an essential receptor for mycobacterial cord factor (trehalose-6,6′-dimycolate, TDM). Mincle gained increasing attention immediately after this critical finding. Although our understanding of the recognition of Mycobacteria has been advanced significantly, it was also revealed that Mincle interacts with pathogens other than Mycobacteria. In addition, endogenous ligands of Mincle were identified recently. Therefore, Mincle is now considered a danger receptor both for self and non-self ligands, so-called damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). This chapter will give an overview of the accumulated knowledge of the multi-task danger receptor Mincle from its discovery to the latest findings.

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Authors and Affiliations

  1. Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan

    Yasunobu Miyake

  2. Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan

    Sho Yamasaki

  3. Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Sho Yamasaki

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  1. Yasunobu Miyake
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  2. Sho Yamasaki
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Correspondence to Yasunobu Miyake .

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  1. Genomics Research Center, Academia Sinica, Taipei, Taiwan

    Shie-Liang Hsieh

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Miyake, Y., Yamasaki, S. (2020). Immune Recognition of Pathogen-Derived Glycolipids Through Mincle. In: Hsieh, SL. (eds) Lectin in Host Defense Against Microbial Infections. Advances in Experimental Medicine and Biology, vol 1204. Springer, Singapore. https://doi.org/10.1007/978-981-15-1580-4_2

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