Fascial Space Infections

Dental infection has plagued humankind for as long as our civilization has been a fight against microorganisms by man dates back to ancient civilization. The discovery of antibiotics is encouraging trends conquest of the microbial infections. Infection of the deep facial spaces of the head and neck still represents a major challenge in hospitals. Untreated infections may result in abscess formation that can spread through different levels in and between the facial spaces and result in life-threatening situations including mediastinitis, pericarditis, meningitis, septic shock, airway compromise, jugular vein thrombosis, and arterial erosion, Although the complications are rare, they are serious and life threatening. The most critical point in the facial space infections is the understanding of the common and uncommon signs and symptoms, choice of antibiotics, definitive treatment and a thorough knowledge about the sequela if left unmanaged.


Definition of Fascial Space
The fascial spaces in the Head and Neck are the potential spaces between the various fascia normally filled with loose connective tissue and bounded by the anatomical barriers usually of bone, muscle, or fascial layers [2].
Facial planes offer anatomic highways for infection to spread superficially to deep planes. Antibiotic availability in fascial spaces is limited due to poor vascularity.

Spread of Infection
The spread of the infections could be either through tissues, blood, or lymphatics leading to fatal consequences like Airway obstruction, Meningitis, and Septicemia; however, various factors influence the spread of infection.
In the Oral and Maxillofacial region, fascial spaces are almost always of relevance due to the spread of odontogenic infections. As such, the spaces can be classified according to their relation to the upper and lower teeth, and whether infection may directly spread into the space called primary space, or must spread via a primary space to the secondary space [3].

Primary Spaces and Secondary Spaces
Failure to adequately treat a primary space infection or a compromised host results in secondary space involvement (Table 21.1).

Cervical Spaces
Since hyoid bone is the most important anatomic structure in the neck that limits the spread of infection, the spaces can be classified according to their relation to the hyoid bone: They are as follows: • Virulence of the organism. • Pathogenicity of the organisms. • Immune status of the patient.   [4] The severity score for a given patient is the sum of the severity scores for all of the spaces involved by cellulitis or abscess, based on clinical and radiological examination (Table 21.2).

Severity Score Anatomic Space
The fascial spaces are divided into: • Spaces around the Maxilla.
• Spaces around the Mandible.
The infections arising from the maxillary anterior teeth spread to Canine space, while the infection from molars spread to Buccal space, Infratemporal space, or cause palatal abscess. Likewise, the infection from the mandibular anterior teeth spread to Submental space or cause gingival abscess. Infection from mandibular molars spread to the Sublingual space or the Submandibular space. While the infection from mandibular third molars spread to Submasseteric space, Pterygomandibular space and Lateral Pharyngeal space.
However, it is not a "rule of thumb" for the involvement of a particular space with a specific tooth infection.

General Priciples of Management of Infection
Pyogenic infections are primarily managed by surgical intervention comprising decompression or drainage. It is better to proceed with decompression at the earliest, without waiting for the localization of the infection (abcess formation), thereby preventing the spread of infection in tissue planes and mounting of pressure under the skin (Table 21.3).

Hilton's Method of Abscess Drainage
(Figs. 21.1a and 21.1b) This is a method of abscess drainage which ensures that no blood vessel or nerve in the vicinity of the incision is damaged. Early decompression has the following benefits: 1. Prevents the spread of infection. 2. Prevents ischemic necrosis of the tissues. 3. Prevents pressure in the tissues. 4. To get rid of toxic purulent discharge. 5. Improves the drainage, by opening the lymphatic and venous channels, which were blocked by the edema and congestion. 6. To allow better perfusion of blood thereby improving the delivery of antibiotics and defensive elements to the required site. 7. Prevents further complications.

Medical Management
Supportive management is mandatory in the form of antibiotics, anti-inflammatory, and electrolytes. The reader is also advised to refer the chapter on general principles of management of facial infections (Chap. 20).

Antibiotic Therapy
Antibiotics are advised depending upon the patient's systemic condition; initially, after pus collection, empirical antibiotic is given; later, after the culture and sensitivity is performed, -specific antibiotics are advised.
Route of administration depends upon the general condition and severity of the infection. Para-enteral route is preferred when the infection is acute and severe or when the patient is nutritionally or medically compromised.
With evidence of slough, gas, crepitus, and foul smell, anaerobic infection may be suspected and appropriate antibiotics have to be given.
Flynn TR [5] in their systemic review concluded that antibiotics should be chosen which are safe and cost effective, because no one antibiotic is clearly superior to all others. In otherwise healthy patient, a 3-4-day regimen of antibiotic therapy should be adequate. The primary importance should be given to the surgical treatment consisting of incision and drainage, extraction, or endodontic therapy of the involved tooth. According to their review, the choice of empiric antibiotics for odontogenic infections is listed in Table 21.4. Martins JR et al. [6] suggests that after incision and drainage/removal of the cause is mandatory. Antibiotics should be administered for the shortest duration possible duration and should act as an adjuvant for the primary surgical treatment in countering any regional or systemic co-morbidities.

Fluid and Electrolytes
Apart from antibiotics and anti-inflammatory drugs, administration of fluids and electrolytes is mandatory, as there is a loss of fluids due to infection and fever. In nonambulatory patients, intravenous fluids are administered depending on their systemic status.
Daily calorie requirement also increases by up to 13% for each degree rise in temperature, which needs to be addressed for a speedy recovery.

Selection of Anesthesia
A simple and superficial abscess can be drained comfortably under local anesthesia, while deep-seated, multi-loculated abcesses may not be amenable for treatment under local anesthesia and may be managed under procedural sedation provided the patient has adequate mouth-opening and patent airway. Fiber-optic intubation or tracheostomy may be considered in; patients with limited mouth opening (trismus) or in patients having intra-oral and pharyngeal infections (sub-lingual, lateral/retropharyngeal spaces) where the chances of aspiration is high in the event of oro/naso-tracheal intubations.

Canine Space/Infraorbital Space
The canine space, synonymous with Infraorbital space, is situated in the anterior surface of the maxilla at the infraorbital region above canine fossa.

Management
Drainage of the space infection either intraorally or percutaneously is done; intraoral incision and drainage are preferred as these will not produce a facial scar. Drainage is made by making an in-depth incision of the maxillary vestibule near canine fossa. Sinus forceps is inserted superiorly, laterally, and medially for complete breakage of locules and drainage. Care is taken while using sinus forceps, so as to not damage the infraorbital nerve and its branches.
Aggressive antibiotic therapy is mandatory to prevent the spread as it lies in the danger area of the face and also to prevent Cavernous sinus thrombosis from septic thrombi entering into angular vein.
The involved tooth is either removed or subjected to root canal treatment with multiple dressings. Patient is advised good hydration and rest.

Buccal Space
The buccal space occupies the portion of the subcutaneous space present between the fascial skin, buccinator muscle, and masseter muscle [8].
Source of infection-From maxillary premolar and molar teeth root apices above buccinator attachment.
From mandibular premolar and molar teeth root apices below the buccinator attachment.

Management
Drainage of the space infection either intraorally or percutaneously is done; intraoral incision and drainage are preferred as these may not produce a facial scar. Drainage is made by making an in-depth incision of the maxillary vestibule near the involved tooth. Sinus forceps is inserted superiorly, laterally, and medially for complete breakage of locules and drainage. Care is taken while using sinus forceps, so as to not to damage duct and artery ( Fig. 21.4a, b, c).
For mandibular buccal space infection, intraoral drainage may not achieve the desired result, hence extraoral drainage at the lower border of mandible is made taking care of the facial artery and marginal mandibular nerve.
The involved tooth is either removed or subjected to root canal treatment as required. Literature advocates early extraction of the involved tooth/teeth. According to Igoumenakis D et al. [9], extraction of the involved tooth shortens the hospital stay and provides faster recovery on a biological level.

Temporal Pouches
Infections in this region are relatively rare to occur when involved swelling occurs at the temporal region above zygomatic arch and behind the lateral orbital rim [10]. They are two in number-Superficial temporal space and Deep temporal space (Fig. 21.5).

Superficial Temporal Space
This space lies between the temporal fascia and temporalis muscle.
Source of infection-From upper third molars and infection from other spaces.
• Anterior-posterior surface of lateral orbital rim.

Contents
• Temporal fat pad.
• Temporal branch of Facial nerve.

Clinical Features
1. Pain and tenderness at the temporal region. 2. Swelling is present above and below zygomatic arch, leading to classical "Dumb bell" shaped appearance ( Fig. 21.6). 3. Trismus may be present.

Management
Surgical drainage is carried out through an incision made above the zygomatic arch; sinus forceps is inserted through the skin incision and passed through the superficial fascia and the temporal fascia.

Deep Temporal Space
This space lies between the temporalis muscle and the skull. Slightly below the level of zygomatic arch; both the superficial and deep temporal spaces communicate with each other.
Source of Infection-Upper third molar and spread from other spaces.

Boundaries
• Superior-Attachment of temporal fascia to the cranium. • Inferior-Lateral pterygoid muscle.
• Medial-Medial pterygoid plate and lower part of infratemporal fossa. • Lateral-Medial surface of the temporalis muscle.

Contents
Branches of Internal maxillary artery. Mandibular division of trigeminal nerve.

Clinical Features
1. Pain. 2. Swelling at the infratemporal region and lateral aspect of the eye. 3. Obliteration of buccal sulcus at tuberosity area. 4. Trismus due to proximity of masticatory muscles. 5. Infection may extend to the infratemporal and pterygomandibular region.

Management
If the trismus is not severe, intraoral incision is given in the buccal sulcus at the second and third molar region. With the sinus forceps, the space is entered medial to coronoid process superiorly and the pus is drained. Corrugated rubber tube is placed and secured with a suture. In case of severe trismus, extraoral incision is made above the zygomatic arch at the junction of frontal and temporal process of zygoma, sinus forceps is inserted and directed inferiorly and medially to enter the space and drain the pus. The disadvantage of this approach is that it cannot produce dependent drainage.

Submental Space
The infection from any of the six anterior teeth in the mandible may perforate the labial bone inferior to the mentalis muscle attachment and the pus may present at the anterior and lower border of the mandible and below the mylohyoid muscle lingually [11].

Management
Transcutaneous approach in the chin region is the most effective drainage; incision is made below the symphysis menti to produce dependent drainage. Sinus forceps is inserted upward and backward to break the locules and the pus is drained. A corrugated rubber drain is inserted and secured with a suture. Intraoral approach is cumbersome as we need to pierce mentalis muscle to reach the submental space and also drainage against gravity is not possible.

Sublingual Space
The space is V-shaped lying lateral to the muscles of the tongue and in the lingual aspect of the body of the mandible. Anteriorly communicates with submental space and posteriorly communicates with the submandibular space at the edge of the mylohyoid muscle [12].

Contents
• Lingual nerve and Hypoglossal nerve.
• Deep part submandibular gland and duct.

Clinical Features
1. Pain and discomfort during deglutition.
2. Due to edema, there is elevation and protrusion of the tongue. 3. In case of laryngeal edema, there may be breathlessness. 4. Speech may be affected. 5. Enlarged and tender submandibular nodes.

Management
• An intraoral incision is made close to lingual cortical plate, near premolar region taking care of lingual nerve and the Wharton's duct. Sinus forceps or a thin mosquito forceps is inserted and the pus is drained. • If an extraoral approach is planned, then incision is placed at the submandibular region, taking care of the facial artery and marginal mandibular nerve; a sinus forceps is inserted piercing the mylohyoid muscle to drain the pus and a corrugated rubber drain is inserted and secured with a suture, as this approach provides gravity-dependent drainage.

Submandibular Space
• The submandibular space is present at the inferior border of the mandible between the anterior and posterior bellies of digastric muscles [13].
• Facial artery and vein. (Fig. 21.9) 1. Pain and tenderness. 2. Swelling is situated at the submandibular region, inferior to the lower of the mandible. 3. Swelling is firm to soft in consistency. 4. Submandibular nodes are palpable and tender. 5. Intraoral-the involved teeth are sensitive. 6. Mild trismus may be noticed.

Management
It is managed through an extraoral approach; incision is placed at the submandibular region in the most dependent area to facilitate gravitational drainage, taking care of the facial artery and marginal mandibular nerve; a sinus forceps is inserted superiorly, medially, and laterally piercing through the superficial fascia. A drain is inserted and secured with a suture to facilitate dependent drainage (Fig. 21.10).

Masticator Space
Masticator space is formed by splitting of the investing fascia into superficial and deep layers. The superficial layer lies along the lateral surface of the masseter and lower half of the temporalis. Deep layer passes along the medial surface of the pterygoid muscles before attaching to the base of the skull superiorly.

Submasseteric Space
Masseter consists of three layers which are firmly attached anteriorly and loose posteriorly. The space is present lateral to ascending ramus of the mandible.  The masticator spaces comprise the following four spaces:

Source of Infection
• Infection from buccally placed lower third molar. • Septic foci from infected angle fracture. • Infection from other space.

Management
The drainage of the infection is done through two approaches.
In intraoral approach, incision is placed at the retromolar area along the anterior border of the ramus of mandible. The sinus forceps is inserted through the incision laterally between the mandibular ramus and the masseter muscle to explore the Submasseteric space. The disadvantage of intraoral technique is that incision and drainage is not gravity dependent.
In extraoral approach, the incision is placed on the skin at the angle and inferior border of the mandible; sinus forceps is inserted directing superiorly piercing the subcutaneous tissue and masseter muscle. Abscess drained corrugated rubber tube is placed and secured with a suture. Precautions are taken not to damage the marginal mandibular nerve (Figs. 21.11 and 21.12).

Pterygomandibular Space
One of the most frequently encountered space in dental office is pterygomandibular space [14].

Source of Infection
• From lower third molar. • Contaminated needle used during inferior alveolar nerve block.

Medial pterygoid muscle Medial Lateral
Masseter muscle ©Association of Oral and Maxillofacial Surgeons of India • Infection from other spaces (Superficial temporal).

Management
Generally, incision and drainage are done through intraoral approach; however, in case of severe trismus, extraoral approach may be indicated. Drainage is done either under general anesthesia or by giving mandibular nerve block.

Intraoral Approach
A vertical incision of 1.5 cm is made at the anterior and medial aspect of the mandible, sinus forceps is inserted into the abscess cavity, and pus is evacuated. Corrugated rubber drain is inserted and sutured to the margins of the incision to prevent dislodgement.

Extraoral Approach
In case of severe trismus, this approach is advised, an incision of 1.5 cm is made on the skin, toward the inner aspect of the angle region. Sinus forceps is inserted toward the medial aspect of the mandible directing superiorly close to the bone. Pus is evacuated and rubber drain is inserted and sutured to the margins of the incision. Figure 21.14 shows various approaches which can be used for fascial space infections and Fig. 21.15 shows submandibular approach to the medial and lateral masticator spaces.

Parapharyngeal Spaces
The spaces around the pharynx form a 'Ring' and a pathway for spread of infections from the orofacial region to the neck and mediastinum. The Parapharyngeal space includes Lateral Pharyngeal space and Retropharyngeal space.

Lateral Pharnygeal Space
It is a potential space lying lateral to the pharynx, extending from base of the skull to the hyoid bone. The space is conical in shape, base being toward the base of the skull and apex toward the hyoid bone.

Management
A combination of intra-oral and extra-oral approaches are advised for the managment of infections of the lateral pharyngeal space. They are preferably done under general anesthesia with care taken to secure the airway. Intraoral approach-A 1.5 cm incision is made on the Pterygomandibular raphe, sinus forceps is passed through the raphe on the medial surface of the mandible, medial aspect of the medial pterygoid muscle, and lateral aspect of the superior constrictor muscle.
Extraoral approach-An incision of 2.5 cm is made in the submandibular region, blunt dissection is then carried through the fascia just anterior to the sternocleidomastoid muscle, and digital palpation can enter and dissect the lateral pharyngeal space bluntly (Fig. 21.16). The landmarks to be palpated are the angle of the mandible anterolaterally, the carotid sheath posterolaterally, the transverse processes of the cervical vertebrae posteromedially, and the endotracheal tube, if present, anteromedially. Caution must be taken not to perforate the posterior oropharyngeal wall by aggressive finger dissection toward the oropharynx [15].
Combined approach-Intraoral incision is made on the mucosa at the medial aspect of the ramus of the mandible, curved hemostasis is inserted lateral to superior constrictor muscle and medial to medial pterygoid muscle and the blunt dissection is carried out posterio-inferiorly below the angle of the mandible. The tip of the instrument is palpated at the anterior border of the sternocleidomastoid muscle extraorally and cutaneous incision is made over the tip. A drain is inserted and sutured to the wound margin to allow drainage.
Maintaining the endo-tracheal tube or tracheostomy may be considered depending on the severity of infection and the success of drainage.

Retropharyngeal Space
It is also called as prevertebral space, which is a potential space present in the midline between the pharyngobasilar ©Association of Oral and Maxillofacial Surgeons of India

Source of Infection
• From Lateral pharyngeal space. • From the lymph nodes that drain into Waldeyer's ring. • Rarely from upper respiratory infections.

Boundaries
• Superior-Base of the skull.

Contents of the Space
• Lymph nodes.

Management
Most important is to secure airway, may be an elective tracheostomy or fiber optic intubation is considered for airway maintenance. Intraoral approach is generally done for the suprahyoid part of the retropharyngeal infection, procedure is similar to the one done for lateral pharyngeal space infection. Intraoral incision is made on the mucosa at the medial aspect of the ramus of the mandible, curved hemostat is inserted lateral to superior constrictor muscle and medial to medial pterygoid muscle, and the blunt dissection is carried out further inferiorly.
Extraoral approach is better for the infection at the infrahyoid region, incision is made transcutaneously anterior to the sternocleidomastoid muscle at the level of the angle of the mandible to the level of the hyoid bone. Both sternocleidomastoid muscle and Carotid sheath are identified, and retracted. Blunt dissection is carried out into lateral and retropharyngeal spaces, later being verified by the palpation of anterior process of the cervical spine posteriorly and the endotracheal tube anteriorly [16]. Drain is placed and secured to the edges of the cutaneous incision.

Peritonsillar Abscess: (Quincy)
It is a localized infection near the tonsils, usually occurring as a secondary infection from the local sites.

Source of Infection
• From tonsillitis. • Rarely from Pericoronitis. • From Lateral pharyngeal space.

Clinical Features
1. Pain in the throat radiating to ear. 2. Fever. 3. Dehydration. 4. Dysphagia. 5. Swelling visible at anterior pillar of tonsillar fauces. 6. Redness and edema may be extended to soft palate. 7. Drooling of saliva. 8. Change of voice and speech difficulty in case of bilateral involvement. 9. Mouth opening difficulty may not be present.

Management
Intraoral approach, superficial incision made at the most prominent area of the swelling near anterior pillar and the soft palate, sinus forceps is inserted deep into the tissues to break all the locules and drain the pus [17].

Sequelae of Space Infections, if Ignored
Possible life-threatening complications may be developed if the space infections of the jaws are not addressed adequately; for ease of understanding, the complications are classified as follows (Table 21.5).

Ludwig's Angina
It was first described by Wilhelm Friedreich Von Ludwig in 1836, and the term Ludwig's Angina was coined by Camerer in 1937. The word Angina is derived from Latin language meaning suffocation or choking. Ludwig's Angina is defined as an acute, firm, nonsuppurating, necrotizing cellulitis involving bilateral Submandibular, Sublingual, and Submental spaces. The condition has been described by medical practitioners, by three unique features, starting with the alphabet 'F'-Feared, Fluctuant rarely, Fatal often.
Many terminologies were used for this condition like Marbus Strangularis, Angina Maligna, and Garotillo.

Specific warning signs in space infections include:
• Dyspnea (difficulty breathing   The infection of the sublingual space rapidly spreads along to its base which is present at the hyoid bone. A characteristic feature is edema of the epiglottis and the vocal cords, due to the spread of infection in a postero-inferior direction from the sub-lingual space to the laryngeal inlet. This may produce acute respiratory obstruction and death [18].

It should be treated as life-threatening situation and intervened aggressively
The treatment of Ludwig's Angina is primarily surgical. The first priority in the management is always the life-saving measure. If the patient shows any signs of dyspnea, Tracheostomy should be performed promptly Endotracheal intubation is nearly impossible due to trismus, tongue elevation, and laryngeal edema. A skilled anesthetist with fiber optic laryngoscope may try Nasoendotracheal intubation, while the patient is conscious and awake, while the tracheostomy kit is kept on standby, in case of emergency (please refer Chap. 7 to read about anesthesia procedures in patients with space infections).
Once the airway is secure, the next step is surgical decompression of spaces and tissue planes; this is achieved by giving multiple cutaneous incisions in the submandibular and submental regions. Decompression of sublingual space is very important, which is achieved by piercing the mylohyoid muscle. This can also be achieved by placing an incision in the floor of the mouth, parallel to the lingual vestibule. There may not be much pus to drain as the condition is usually non-supperative ( Fig. 21.18a, b, c). Corrugated rubber drain may be left in situ to keep the incisions patient and to drain the exudates [19] Treatment protocol is as follows: • Early diagnosis.  After decompression, simultaneous removal of the cause is important, as this is the source of the condition.
Intravenous fluids are administered to maintain proper fluid and electrolyte balance and to fulfill the nutritional requirement of the patient. Definitive antibiotics are given intravenously based on the culture and sensitivity reports. Other symptomatic medicines like anti-inflammatory and analgesics may be prescribed. Local wound care is taken care of by irrigation and dressings. Drains to be changed every 48 hrs and maintained until the condition resolves.

Necrotizing Fasciitis
Necrotizing fasciitis is an uncommon soft tissue infection, occurs due to polymicrobes and spreads rapidly in the subcutaneous tissue and above superficial fascia, and as the disease progresses, muscle and skin involve giving rise to myonecrosis. The other name for this condition is Hospital Gangrene given by Brooks in 1966 and Hemolytic streptococcal gangrene. Necrotizing fasciitis may affect any part of the body; however, it most commonly affects the extremities, abdominal wall, and the perineum following trauma or surgery.
The condition shows no clear boundaries or palpable limits, mainly occurs with immunocompromised patients and those suffering from systemic illnesses (Fig. 21.19).

Source
The causative organisms in this condition are multiple like Aerobic Group A-hemolytic Streptococcus and Staphylococcus and later identified microbes are Bacteroids, Proteus, coliforms, and peptostreptococcus. In most cases, the pathogens gain entry through disruption of the skin caused by trauma or surgery. Continuous bacterial overgrowth and synergy cause a decrease in oxygen tension and develop local ischemia and proliferation of anaerobic bacteria. The fulminating nature of the necrotic process is the result of the symbiotic relationship between the bacteria. (Table 21.

Management
Early recognition and aggressive surgical intervention is mandatory; taking the medical parameters into consideration and airway maintenance, general anesthesia is preferred in most cases. Initially, intravenous broad spectrum antibiotics are administered to control the spread of the infection; these antibiotics may be changed once the culture report is obtained.  Purpose of decompression is threefold: 1. Reduces tension within the tissue planes and prevents further spread of infection. 2. As the pressure in the tissue drops, circulation improves and facilitates the reduction of the edema. 3. Drains septic material and prevents bacteremia.
Surgical treatment is obligatory with incision and drainage, in addition to vigorous debridement of the necrotic fascia, subcutaneous tissue, muscle, and skin. Excision of tissue to the point of fresh bleeding is advised. Multiple and regular change of dressings are needed till the condition is resolved.
Some centers may follow Hyperbaric oxygen therapy for this condition.

Cavernous Sinus Thrombosis
Cavernous sinuses are the venous sinuses situated on either side of the sella tursica. The cavernous sinus on either side communicates freely with each other by anterior and posterior intracavernous sinuses they also communicate with sagittal sinus, transverse, sinus and sigmoid sinus. The cavernous sinus communicates extra cranially with veins of the head and neck.
1. The ophthalmic vein and angular veins into the anterior facial vein. 2. Through emissary veins from the pterygoid plexus of veins.
External route-Infection from face and lips carried by facial and angular veins and nasofrontal veins to the superior ophthalmic vein passes through the superior orbital fissure and enters the cavernous sinus.
Internal route-Infection from the posterior maxillary region to the pterygoid plexus to the inferior ophthalmic vein through the inferior orbital fissure and then through the superior orbital fissure to the cavernous sinus.

Source
The area of the face between the inner canthus of the eyes and the corners of the mouth is called `Danger Triangle` of the face and any kind of severe sepsis in this area can spread in a retrograde manner and can extend to the cavernous sinus through the angular vein and ophthalmic vein.
Causative agents identified are Streptococcus, Staphylococcus, and Gram negative microbes.
• Increased intracranial pressure due to venous congestion and cerebral edema. • Altered level of consciousness. • Pyogenic meningitis leading to brain abscess. • Erosion of the internal carotid artery leading to fatal intracranial hemorrhage.

Eagleton Criteria
Diagnostic criteria were suggested by Eagleton, prior to modern investigative methods.
1. Known site of infection or septicaemia. 2. Evidence of blood stream infection. 3. Early signs of venous obstruction in the retina, conjunctiva, or eyelid. 4. Paresis of the third, fourth, and sixth cranial nerve. 5. Abscess formation in the neighboring soft tissue. 6. Evidence of meningeal irritation.

Management
The patient should be given broad spectrum intra venous antibiotics preferably those which cross the blood brain barrier. Aminoglycosides and Clindamycin are started in high therapeutic doses. IV Mannitol is given to decrease the intra cranial pressure. Anticoagulant Heparin 20,000 units in 1500 ml of 5% Dextrose is advised to reduce thrombosis.
Neurosurgical intervention is mandatory.

Meningitis
It is one of the neurological complications resulting from the infection of oro-facial region. It may develop from metastatic spread or may be due to nearby thrombophlebitis.

Diagnosis
Diagnosis is based on cerebrospinal fluid analysis. In CSF polymorpho-nuclear leukocytes, elevated protein levels and decreased glucose levels are noticed.

Treatment
-Initially with Chloramphenicol 4 g/day-IV associated with Penicillin G 24 million units per day IV -Mandatory neurosurgical consultation.
-For raised intracranial pressure IV Manniotol is given. Maintenance of hydro-electrolyte balance is recommended. Change of antibiotics if required after culture and sensitivity report.

Conclusion
Odontogenic infections are typically polymicrobial. The pathogenesis of odontogenic infections depend on a synergistic relationship between aerobic and anaerobic bacteria.
The last decade showed a notable change in the behavior of odontogenic infections. The severity of these infections is far greater than in the past, demanding swift recognition of the disease followed by prompt and more aggressive treatment. Failing to identify and treat these infections promptly may result in disastrous outcomes.
Definitive treatment includes airway management, adequate resuscitation and optimization of pre-existing medical conditions prior to removal of the source of infection, and drainage of pus.
Oral and high-dose intravenous antibiotics should be administered as required depending on the severity of infection and based on the decision whether the patient is treated on an outpatient or inpatient basis, with the initial choice of antibiotics modified in the light of subsequent bacteriological reports. The treatment of all odontogenic infections must include removal of the focus of infection and drainage of pus.