Abstract
Atropine is a poisonous white crystalline alkaloid extracted from roots and leaves of dianqiecao (Belladonnae Herba) and mantuoluo (Mandala). Atropine sulphate is commonly used in clinics. Atropine is a blocker of typical M-choline receptor. Therefore, atropine sulphate was mainly used to treat toxic shock and organic phosphorus pesticide poisoning, to relieve visceral colic, as preanaesthetic medication and to reduce bronchial mucus secretion. The indications of atropine sulphate eye gel are iridocyclitis, fundus examination and mydriasis. However, clinical application of atropine sulphate was limited, because of its toxicity and small dosage window. After a prolonged endeavour, some progress has been made in respects such as fast action, longer duration of action, reduction of side effects and convenient use.
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References
Chinese Pharmacopoeia Commission. Chinese pharmacopoeia. Beijing: The Medical Science and Technology Press of China; 2015. p. 1335–7.
Brief history of drug discovery – atropine. http://news.anychem.com/detail/YRGzaa.html.
Hangzhou first pharmaceutical factory. Synthesis process of atropine sulfate. Chin J Pharm. 1972;8:15–7.
Shi BX. Reasonable application of belladonna drugs to rescue organophosphorus pesticide poisoning. New Drugs Clin Remedies. 1986;5(5):288–91.
Bedrossian RH. The effect of atropine on myopia. Ann Ophthalmol. 1971;3(8):891–7.
Chen M, Wang LC. Research progress of atropine prevention and treatment of myopia. J Med Forum. 2010;31(3):125–7.
Liu JG, Wang Z, Liu ZZ, et al. Preventive application of atropine to patients receiving carotid arteries stenting. Neural Inj Funct Reconstr. 2013;8(3):192–3.
Liu FR, Yi CY. Therapeutic dose of atropine to psychiatric disorders in 1 case. Contemp Med. 2013;19(25):48.
Qin ZG, Chen ZH, Li RD. The research progress of dosage forms of atropine sulfate. Chin Foreign Med Treat. 2009;33:168–9.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Fang, LH., Wang, JH., Du, GH. (2018). Atropine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_29
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DOI: https://doi.org/10.1007/978-981-10-8022-7_29
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