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Formation of New Cardiomyocytes in Exercise

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Exercise for Cardiovascular Disease Prevention and Treatment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 999))

Abstract

Heart failure is a life-threatening disorder associated with the loss of cardiomyocytes. The heart has some endogenous although limited regenerative capacity, thus enhancing cardiac regeneration or stimulating endogenous repair mechanism after cardiac injury is of great interest. The benefits of exercise in heart diseases have been recognized for centuries. Besides the promotion of a favorable cardiac function, exercise is also associated with new cardiomyocytes formation. Exercise may lead to cardiomyocytes renewal from pre-existing cardiomyocytes proliferation or cardiac stem/progenitor cells differentiation. A deep understanding of exercise-induced formation of new cardiomyocytes will enable us to develop novel therapeutics for heart diseases.

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Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China (81570362, 91639101 and 81200169 to JJ Xiao and 81400647 to Y Bei), and the development fund for Shanghai talents (to JJ Xiao), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042), the grant from Science and Technology Commission of Shanghai Municipality (17010500100).

Competing Financial Interests

The authors declare no competing financial interests.

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Author notes

  1. Liang Shen, Hui Wang and Yihua Bei contributed equally to this work.

Authors and Affiliations

  1. Physical Education College of Shanghai University, Shanghai, 200444, China

    Liang Shen

  2. Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China

    Hui Wang

  3. Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China

    Yihua Bei & Junjie Xiao

  4. Victor Babes National Institute of Pathology, Bucharest, 050096, Romania

    Dragos Cretoiu & Sanda Maria Cretoiu

  5. Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania

    Dragos Cretoiu & Sanda Maria Cretoiu

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  1. Liang Shen
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  2. Hui Wang
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  3. Yihua Bei
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  4. Dragos Cretoiu
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  6. Junjie Xiao
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Correspondence to Junjie Xiao .

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Editors and Affiliations

  1. Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Shen, L., Wang, H., Bei, Y., Cretoiu, D., Cretoiu, S.M., Xiao, J. (2017). Formation of New Cardiomyocytes in Exercise. In: Xiao, J. (eds) Exercise for Cardiovascular Disease Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 999. Springer, Singapore. https://doi.org/10.1007/978-981-10-4307-9_6

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