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Aquaporins in Respiratory System

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Aquaporins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 969))

Abstract

Aquaporins (AQPs ) are water channel proteins supposed to facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion . In this chapter, we mainly focus on the expression of 4 AQPs in the lungs which include AQP1, AQP2 , AQP4 and AQP5 in normal and disease status, and the experience of AQPs function from various model and transgenic mice were summarized in detail to improve our understanding of the role of AQPs in fluid balance of respiratory system. It has been suggested that AQPs play important roles in various physiology and pathophysiology conditions of different lung diseases. There still remains unclear the exact role of AQPs in lung diseases, and thus continuous efforts on elucidating the roles of AQPs in lung physiological and pathophysilogical processes are warranted.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (81100046, 30930090, 81170056), and by grant B115 from Shanghai Leading Academic Discipline Project. Dr. Yuanlin Song was supported by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and Key Medical grant from Shanghai Science and Technology Committee (11411951102, 12JC1402300), by the State Key Basic Research Program (973) project (2015CB553404), and by Doctoral Fund of Ministry of Education of China (20130071110044).

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Yuanlin Song M.D., Linlin Wang M.D., Jian Wang M.D. & Chunxue Bai M.D., Ph.D.

  2. Shanghai Respiratory Research Institute, Shanghai Public Health Clinical Center, Shanghai, 201508, China

    Yuanlin Song M.D.

  3. Zhongshan Hospital, Qingpu Branch, Fudan University, Shanghai, 201700, China

    Yuanlin Song M.D.

Authors
  1. Yuanlin Song M.D.
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  2. Linlin Wang M.D.
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  3. Jian Wang M.D.
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  4. Chunxue Bai M.D., Ph.D.
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Correspondence to Yuanlin Song M.D. .

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Editors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Song, Y., Wang, L., Wang, J., Bai, C. (2017). Aquaporins in Respiratory System. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_7

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