Skip to main content
SpringerLink
Log in

Role of Catecholamines in Blood Pressure Regulation

  • Chapter
Hypertensive Cardiovascular Disease: Pathophysiology and Treatment

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 16))

  • 250 Accesses

Abstract

Catecholamines are compounds composed of a catechol nucleus (a benzene ring with two adjacent hydroxyl groups) and an amine-containing side-chain. The catecholamines occurring in man are dopamine, noradrenaline, and adrenaline. Dopamine serves as a neurotransmitter in the central nervous system. Furthermore, this amine functions as a precursor for noradrenaline and adrenaline. Noradrenaline is synthesized in the chromaffin tissue, in parts of the brain, and in the postganglionic sympathetic nerves, where it serves as the neurotransmitter substance. Adrenaline is synthesized in the brain and in the chromaffin cells. Most of the adrenaline is formed in the chromaffin cells of the adrenal medulla, from where it is secreted into the blood.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blaustein MP: The role of calcium in catecholamine release from adrenergic nerve terminals. In: The Release of Catecholamines from Adrenergic Neurons, pp. 39–58. Paton DM, ed. Oxford: Pergamon, 1979.

    Google Scholar 

  2. Starke K, Taube HD, Borowski E: Presynaptic receptor systems in catecholaminergic transmission. Biochem Pharmacol 26: 259–268, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Stjärne L: Role of prostaglandins and cyclic adenosine monophate in release. In: The Release of Catecholamines from Adrenergic Neurons, pp. 111–142. Paton DM ed. Oxford: Pergamon, 1979.

    Google Scholar 

  4. Muscholl E: Peripheral muscarinic control of norepinephrine release in the cardiovascular system. Am J Physiol 239: H713–H720, 1980.

    PubMed  CAS  Google Scholar 

  5. von Euler US, Franksson C, Hellström J: Adrenaline and noradrenaline output in urine after unilateral and bilateral adrenalectomy in man. Acta Physiol Scand 31: 1–5, 1954.

    Article  Google Scholar 

  6. Reid JL: Plasma noradrenaline as an index of sympathetic activity. In: Hypertension. Mechanisms and Management, pp. 65–71. Philipp T, Distler A, eds. Berlin: Springer-Verlag, 1980.

    Chapter  Google Scholar 

  7. Whitby LG, Axelrod J, Weil-Malherbe H: The fate of H3-norepinephrine in animals. J Pharmacol Exp Ther 132: 193–201, 1961.

    PubMed  CAS  Google Scholar 

  8. Wurtman RJ: Catecholamines. Boston: Little, Brown, 1966.

    Google Scholar 

  9. Kopin IJ: Storage and metabolism of catecholamines: the role of monoamine oxidase. Pharmacol Rev 16: 179–191, 1964.

    PubMed  CAS  Google Scholar 

  10. Kopin IJ: Biochemical assessment of peripheral adrenergic activity. In: The release of catecholamines from adrenergic neurons, pp. 355–372. Paton DM, ed. Oxford: Pergamon, 1979.

    Google Scholar 

  11. Langer SZ, Massingham R, Shepperson NB: Presence of postsynaptic § 2-adrenoceptors of predominantly extrasynaptic location in the vascular smooth muscle of the dog hind limb. Clin Sci 59: 225s–228s, 1980.

    PubMed  CAS  Google Scholar 

  12. Davis JO, Freeman RH: Mechanisms regulating renin release. Physiol Rev 56: 2–56, 1976.

    Google Scholar 

  13. Starke K: Action of angiotensin on uptake, release and metabolism of 14C-noradrenaline by isolated rabbit hearts. Eur J Pharmacol 14: 112–123, 1971.

    Article  PubMed  CAS  Google Scholar 

  14. Philipp T. Brokamp B, Cordes U, Lüth B, Distler A: Sympathikusaktivität und pressorische Wirkung von Noradrenalin bei Patienten mit hypo- und hyperthyreoter Stoffwechsellage. Verh Dtsch Ges Inn Med 85: 1047–1049, 1979.

    Google Scholar 

  15. Abboud FM, Heistad DD, Mark AL, et al.: Reflex control of the peripheral circulation. Prog Cardiovasc Dis 18: 371 - 403, 1976.

    Article  PubMed  CAS  Google Scholar 

  16. Robertson D, Shand DG, Hollifield JW, Nies AS, Frölich JC, Oates JA: Alterations in the responses of the sympathetic nervous system and renin in borderline hypertension. Hypertension 1: 118–124, 1979.

    PubMed  CAS  Google Scholar 

  17. DiCara LV, Miller NE: Instrumental learning of vasomotor responses by rats: learning to respond differentially in the two ears. Science 159: 1485–1486, 1968.

    Article  PubMed  CAS  Google Scholar 

  18. Engelman K, Portnoy B, Lovenberg W: A sensitive and specific double-isotope derivative method for the determination of catecholamines in biological specimens. Am J Med Sci 255: 259–268, 1968.

    Article  PubMed  CAS  Google Scholar 

  19. DaPrada M, Zürcher G: Simultaneous radio-enzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci 19: 1161–1174, 1976.

    Article  CAS  Google Scholar 

  20. Peuler JD, Johnson GA: Simultaneous single isotope radioenzymatic assay of plasma nor-epinephrine, epinephrine and dopamine. Life Sci 21: 625–636, 1977.

    Article  PubMed  CAS  Google Scholar 

  21. Miura Y, Campese V, de Quattro V, Meijer D: Plasma catecholamines via an improved fluorimetric assay: comparison with an enzymatic method. J Lab Clin Med 89: 421–427, 1977.

    PubMed  CAS  Google Scholar 

  22. Sever PS: Catecholamines in essential hypertension: The present controversy. In: Circulating Catecholamines and Blood Pressure, pp. 1–10. Birkenhäger WH, Falke HE, eds. Utrecht: Bunge Scientific, 1978.

    Google Scholar 

  23. Lake CR, Ziegler MG, Coleman MD, Kopin IJ: Age-adjusted plasma-norepinephrine levels are similar in normotensive and hypertensive subjects. N Engl J Med 296: 208–209, 1977.

    Article  PubMed  CAS  Google Scholar 

  24. Pedersen EB, Christensen NJ: Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques. Acta Med Scand 198: 373–377, 1975.

    Article  PubMed  CAS  Google Scholar 

  25. Sever PS, Osikowska B, Birch M, Tunbridge RDG: Plasma noradrenaline in essential hypertension. Lancet 1: 1078–1081, 1977.

    PubMed  CAS  Google Scholar 

  26. De Champlain J, Cousineau D: Lack of correlation between age and circulating catecholamines in hypertensive patients. N Engl J Med 297: 672, 1977.

    PubMed  Google Scholar 

  27. De Quattro V, Chan S: Raised plasma catecholamines in some patients with primary hyper-tension. Lancet 1: 806–809, 1972.

    Article  Google Scholar 

  28. Wallin BG, Sundlöf G, Eriksson B-M, Dominiak P, Grobecker H, Lindblad LE: Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand 111: 69–73, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. De Champlain J, Farley L, Cousineau D, van Ameringen M-R: Circulating catecholamine levels in human and experimental hypertension. Circ Res 38: 109–114, 1976.

    PubMed  Google Scholar 

  30. Lake CR, Ziegler MG, Kopin IJ: Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man. Life Sci 18: 1315–1326, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Vecht RJ, Gordon D, Sever P: Catecholamines, isometric exercise and left ventricular function. In: Hypertension. Mechanisms and Management, pp. 55–63. Philipp T, Distler A, eds. Berlin: Springer-Verlag, 1980.

    Chapter  Google Scholar 

  32. Jones DH, Allison DJ, Hamilton CA, Reid JL: Selective venous sampling in the diagnosis and localization of phaeochromocytoma. Clin Endocrinol 10: 179–186, 1979.

    Article  CAS  Google Scholar 

  33. De Champlain J: The contribution of the sympathetic nervous system to arterial hypertension. Canad J Physiol Pharmacol 56: 341–353, 1978.

    Article  Google Scholar 

  34. Haefely W, Hiirlimann A, Thoenen H: Relation between the rate of stimulation and the quantity of noradrenaline liberated from sympathetic nerve endings in the isolated perfused spleen of the cat. J Physiol 181: 48–58, 1965.

    PubMed  CAS  Google Scholar 

  35. Yamaguchi N, de Champlain J, Nadeau R: Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog. Circulat Res 36: 662–667, 1975.

    PubMed  CAS  Google Scholar 

  36. Irving MH, Britton BJ, Wood WG, Padgham C, Carruthers M: Effects of ß-adrenergic blockade on plasma catecholamines in exercise. Nature (London) 248: 531–533, 1974.

    Article  CAS  Google Scholar 

  37. Distler A, Keim HJ, Cordes U, Philipp T, Wolff HP: Sympathetic responsiveness and anti-hypertensive effect of beta-receptor blockade in essential hypertension. Am J Med 64: 446–451, 1978.

    Article  PubMed  CAS  Google Scholar 

  38. de Leeuw PW, Wester A, Willemse PJ, Birkenhäger WH: Patterns of noradrenaline and renin in essential hypertension - effects of stress and therapy. In: Hypertension. Mechanisms and Management, pp. 49–54. Philipp T, Distler A, eds. Berlin: Springer-Verlag, 1980.

    Chapter  Google Scholar 

  39. Romoff MS, Keusch G, Campese VM, Wang M-S, Friedler RM, Weidmann P, Massry SG: Effect of sodium intake on plasma catecholamines in normal subjects. J Clin Endocrinol Metabol 48: 26–31, 1978.

    Article  Google Scholar 

  40. Bannister R, Sever PS, Gross M: Cardiovascular reflexes and biochemical responses in progressive autonomic failure. Brain: 100: 324–344, 1977.

    Article  Google Scholar 

  41. Louis WJ, Doyle AE, Anavekar SH: Plasma norepinephrine levels in essential hypertension. N Engl J Med 288: 599–601, 1973.

    Article  PubMed  CAS  Google Scholar 

  42. Brecht HM, Schoeppe W: Relation of plasma noradrenaline to blood pressure, age, sex and sodium balance in patients with essential hypertension and in normotensive subjects. Clin Sci mol Med 55: 81s–83s, 1978.

    CAS  Google Scholar 

  43. Bertel O, Bühler FR, Kiowski W, Liitold BE: Decreased beta-adrenoceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 2: 130–138, 1980.

    PubMed  CAS  Google Scholar 

  44. Philipp T, Cordes U, Distler A: Sympathetic nervous system and blood pressure control in essential hypertension. Lancet ii: 959–963, 1978.

    Google Scholar 

  45. Le Blanc J, Côté J, Jobin M, Labrie A: Plasma catecholamines and cardiovascular responses to cold and mental activity. J Appl Physiol 47: 1207–1211, 1979.

    Google Scholar 

  46. Weidmann P, Beretta-Piccoli C, Ziegler WH, Keusch G, Glück Z, Reubi FC: Age versus urinary sodium forjudging renin, aldosterone, and catecholamine levels: studies in normal subjects and patients with essential hypertension. Kidney Int 14: 619–628, 1978.

    Article  PubMed  CAS  Google Scholar 

  47. Engelman K, Portnoy B, Sjoerdsma A: Plasma catecholamine concentrations in patients with essential hypertension. Circ Res 26 and 27 (Suppl. I): 141–145, 1970.

    CAS  Google Scholar 

Download references

Authors
  1. A. Distler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven, K.U. Leuven, 3000, Leuven, Belgium

    A. Amery , R. Fagard , P. Lijnen  & J. Staessen , ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Martinus Nijhoff Publishers, The Hague

About this chapter

Cite this chapter

Distler, A. (1982). Role of Catecholamines in Blood Pressure Regulation. In: Amery, A., Fagard, R., Lijnen, P., Staessen, J. (eds) Hypertensive Cardiovascular Disease: Pathophysiology and Treatment. Developments in Cardiovascular Medicine, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7476-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-7476-0_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7478-4

  • Online ISBN: 978-94-009-7476-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation