Abstract
A collaborative effort between researchers at Chas. Pfizer, Inc. and at the Sloan-Kettering Institute led to the discovery that a filtrate from cultures of Streptomyces flocculus had significant anticancer and antibiotic activity. The active agent was eventually isolated, named streptonigrin, and shown to have the structure depicted in (1). During the last twenty years streptonigrin has been the subject of intensive study regarding its use as an anticancer drug, its cytotoxic mechanism of action, its laboratory synthesis, and its biosynthesis.
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References
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Gould, S.J., Weinreb, S.M. (1982). Streptonigrin. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8656-5_3
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