Zusammenfassung
Die größte ROS-Menge entsteht in den Mitochondrien. Physiologische Mengen sind Signalsubstanzen und dauerhaft überhöhte schädigen. Die Mitochondrien haben viele Funktionen für den gesunden Zustand und bei krankhaften Entwicklungen.
Aerobes Training verursacht oxidativen Stress, dem die Verbesserung der antioxidativen und der Reparaturkapazität entgegensteht. Das Erbmaterial wird geschützt und u. a. die antionkologische Trainingswirkung mitbegründet. Die ROS sind u. a. Faktoren der kontraktilen Funktion, der Regulation der Immunität, der Myokinproduktion und der Mikrozirkulation.
Dem trainings- steht der inaktivitätsbedingte ROS-Stress entgegen. Die ROS werden zum Ursprung pathophysiologischer Reaktionsketten. Die „Mito-Entzündung“ führt zu schädlichen Reaktionen und pro-inflammatorischen Zytokinen. Chronisch hohe ROS-Spiegel stehen für neurodegenerative, metabolische, kardiovaskuläre, gastrointestinale und onkologische Erkrankungen und den Alterungsprozess.
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Laube, W. (2023). Ausdauer: Mikrozirkulation, aerober Energiestoffwechsel, Sarkopenie, Schmerzen. In: Bewegungsmangel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-67753-7_7
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