Skip to main content
SpringerLink
Log in

Precision Oncology: Grundlagen und Klassifikationen

  • Chapter
  • First Online:
Die Urologie

Part of the book series: Springer Reference Medizin ((SRM))

  • 65 Accesses

Zusammenfassung

Die Präzisions-Onkologie steht für eine zielgerichtete, hoch-effektive sowie nebenwirkungsarme Tumortherapie. Ziel der molekularen Präzisionsonkologie ist die Beeinflussung eines definierten, direkten oder indirekten tumorspezifischen Zielmoleküls. Voraussetzung für diese Entwicklung ist die Identifizierung von klinisch relevanten, funktionalisierten Zielstrukturen in der Pathogenese onkologischer Erkrankungen, die Implementierung von prädiktiven Biomarkern sowie die Translation der gewonnenen Daten (einschließlich Hochdurchsatzverfahren). In diesem Kapitel soll näher auf die Prinzipien der medikamentösen, präzisionsonkologischen Therapiemöglichkeiten eingegangen werden, welche aktuell im Rahmen molekularer Tumorboards an universitären Zentren stattfindet bzw. vorangetrieben werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Abou-Alfa GK, Sahai V, Hollebecque A, Vaccaro G, Melisi D, Al-Rajabi R, Paulson AS, Borad MJ, Gallinson D, Murphy AG, Oh DY, Dotan E, Catenacci DV, Van Cutsem E, Ji T, Lihou CF, Zhen H, Féliz L, Vogel A (2020) Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study. Lancet Oncol 21(5):671–684

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Andre F, Mardis E, Salm M, Soria JC, Siu LL, Swanton C (2014) Prioritizing targets for precision cancer medicine. Ann Oncol 25(12):2295–2303

    Article  CAS  PubMed  Google Scholar 

  • Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, Haller F, Mack E, Nowak D, Paret C, Schanze D, von Bubnoff N, Wagner S, Busch H, Boerries M, Christoph J (2020) Requirements analysis and specification for a molecular tumor board platform based on cBioPortal. Diagnostics (Basel) 10(2):93

    Article  PubMed  Google Scholar 

  • Chakravarty D, Gao J, Phillips SM, Kundra R, Zhang H, Wang J, Rudolph JE, Yaeger R, Soumerai T, Nissan MH, Chang MT, Chandarlapaty S, Traina TA, Paik PK, Ho AL, Hantash FM, Grupe A, Baxi SS, Callahan MK, Snyder A, Chi P, Danila D, Gounder M, Harding JJ, Hellmann MD, Iyer G, Janjigian Y, Kaley T, Levine DA, Lowery M, Omuro A, Postow MA, Rathkopf D, Shoushtari AN, Shukla N, Voss M, Paraiso E, Zehir A, Berger MF, Taylor BS, Saltz LB, Riely GJ, Ladanyi M, Hyman DM, Baselga J, Sabbatini P, Solit DB, Schultz N, Onco KB (2017) A precision oncology knowledge base. JCO Precis Oncol 2017:PO.17.00011

    PubMed  Google Scholar 

  • Cotto KC, Wagner AH, Feng YY, Kiwala S, Coffman AC, Spies G, Wollam A, Spies NC, Griffith OL, Griffith M (2018) DGIdb 3.0: a redesign and expansion of the drug-gene interaction database. Nucleic Acids Res 46(D1):D1068–D1073

    Article  CAS  PubMed  Google Scholar 

  • Damodaran S, Miya J, Kautto E, Zhu E, Samorodnitsky E, Datta J, Reeser JW, Roychowdhury S (2015) Cancer driver log (CanDL): catalog of potentially actionable cancer mutations. J Mol Diagn 17(5):554–559

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dickson D, Johnson J, Bergan R, Owens R, Subbiah V, Kurzrock R (2020) Snapshot: trial types in precision medicine. Cell 181(1):208–208.e1. https://doi.org/10.1016/j.cell.2020.02.032. PMID: 32243791

    Article  CAS  PubMed  Google Scholar 

  • Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM (2018) Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med 378(8):731–739

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, Ding M, Bamford S, Cole C, Ward S, Kok CY, Jia M, De T, Teague JW, Stratton MR, McDermott U, Campbell PJ (2015) COSMIC: exploring the world’s knowledge of somatic mutations in human cancer. Nucleic Acids Res 43(Database issue):D805–D811

    Article  CAS  PubMed  Google Scholar 

  • Hinderer M, Boerries M, Haller F, Wagner S, Sollfrank S, Acker T, Prokosch HU, Christoph J (2017) Supporting molecular tumor boards in molecular-guided decision-making – the current status of five German university hospitals. Stud Health Technol Inform 236:48–54

    PubMed  Google Scholar 

  • Hinderer M, Boerries M, Boeker M, Neumaier M, Loubal FP, Acker T, Brunner M, Prokosch HU, Christoph J (2018) Implementing pharmacogenomic clinical decision support into German hospitals. Stud Health Technol Inform 247:870–874

    PubMed  Google Scholar 

  • Hoefflin R, Geißler AL, Fritsch R, Claus R, Wehrle J, Metzger P, Reiser M, Mehmed L, Fauth L, Heiland DH, Erbes T, Stock F, Csanadi A, Miething C, Weddeling B, Meiss F, von Bubnoff D, Dierks C, Ge I, Brass V, Heeg S, Schäfer H, Boeker M, Rawluk J, Botzenhart EM, Kayser G, Hettmer S, Busch H, Peters C, Werner M, Duyster J, Brummer T, Boerries M, Lassmann S, von Bubnoff N (2018) Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience. JCO Precis Oncol 2:PO.18.00105

    PubMed  PubMed Central  Google Scholar 

  • Hoefflin R, Lazarou A, Hess ME, Reiser M, Wehrle J, Metzger P, Frey AV, Becker H, Aumann K, Berner K, Boeker M, Buettner N, Dierks C, Duque-Afonso J, Eisenblaetter M, Erbes T, Fritsch R, Ge IX, Geißler AL, Grabbert M, Heeg S, Heiland DH, Hettmer S, Kayser G, Keller A, Kleiber A, Kutilina A, Mehmed L, Meiss F, Poxleitner P, Rawluk J, Ruf J, Schäfer H, Scherer F, Shoumariyeh K, Tzschach A, Peters C, Brummer T, Werner M, Duyster J, Lassmann S, Miething C, Boerries M, Illert AL, von Bubnoff N (2021) Transitioning the molecular tumor board from proof of concept to clinical routine: a German single-center analysis. Cancers (Basel) 13(5):1151. https://doi.org/10.3390/cancers13051151. PMID: 33800365; PMCID: PMC7962829

    Article  PubMed  Google Scholar 

  • Horak P, Klink B, Heining C, Gröschel S, Hutter B, Fröhlich M, Uhrig S, Hübschmann D, Schlesner M, Eils R, Richter D, Pfütze K, Geörg C, Meißburger B, Wolf S, Schulz A, Penzel R, Herpel E, Kirchner M, Lier A, Endris V, Singer S, Schirmacher P, Weichert W, Stenzinger A, Schlenk RF, Schröck E, Brors B, von Kalle C, Glimm H, Fröhling S (2017) Precision oncology based on omics data: the NCT Heidelberg experience. Int J Cancer 141(5):877–886

    Article  CAS  PubMed  Google Scholar 

  • Horak P, Leichsenring J, Goldschmid H, Kreutzfeldt S, Kazdal D, Teleanu V, Endris V, Gieldon L, Allgäuer M, Volckmar AL, Dikow N, Renner M, Kirchner M, Penzel R, Ploeger C, Brandt R, Seker-Cin H, Budczies J, Heilig CE, Neumann O, Schaaf CP, Schirmacher P, Fröhling S, Stenzinger A (2021a) Assigning evidence to actionability: an introduction to variant interpretation in precision cancer medicine. Genes Chromosom Cancer. https://doi.org/10.1002/gcc.22987. Epub ahead of print. PMID: 34331337

  • Horak P, Heining C, Kreutzfeldt S, Hutter B, Mock A, Hullein J, Frohlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Mohrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgauer M, Ruhnke L, Lassmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfutze K, Georg C, Meissburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schrock E, Hubschmann D, Weichert W, Glimm H, Frohling S (2021b) Comprehensive genomic and transcriptomic analysis for guiding therapeutic decisions in patients with rare cancers. Cancer Discov candisc.0126.2021. https://doi.org/10.1158/2159-8290.CD-21-0126. Epub ahead of print. PMID: 34112699

  • Landrum MJ, Lee JM, Riley GR, Jang W, Rubinstein WS, Church DM, Maglott DR (2014) ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 42(Database issue):D980–D985

    Article  CAS  PubMed  Google Scholar 

  • Legrand J, Gogdemir R, Bousquet C, Dalleau K, Devignes MD, Digan W, Lee CJ, Ndiaye NC, Petitpain N, Ringot P, Smaïl-Tabbone M, Toussaint Y, Coulet A (2020) PGxCorpus, a manually annotated corpus for pharmacogenomics. Sci Data 7(1):3

    Article  PubMed  PubMed Central  Google Scholar 

  • Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O‘Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N, DePristo M, Do R, Flannick J, Fromer M, Gauthier L, Goldstein J, Gupta N, Howrigan D, Kiezun A, Kurki MI, Moonshine AL, Natarajan P, Orozco L, Peloso GM, Poplin R, Rivas MA, Ruano-Rubio V, Rose SA, Ruderfer DM, Shakir K, Stenson PD, Stevens C, Thomas BP, Tiao G, Tusie-Luna MT, Weisburd B, Won HH, Yu D, Altshuler DM, Ardissino D, Boehnke M, Danesh J, Donnelly S, Elosua R, Florez JC, Gabriel SB, Getz G, Glatt SJ, Hultman CM, Kathiresan S, Laakso M, McCarroll S, McCarthy MI, McGovern D, McPherson R, Neale BM, Palotie A, Purcell SM, Saleheen D, Scharf JM, Sklar P, Sullivan PF, Tuomilehto J, Tsuang MT, Watkins HC, Wilson JG, Daly MJ, MacArthur DG, Exome Aggregation Consortium (2016) Analysis of protein-coding genetic variation in 60,706 humans. Nature 536(7616):285–291

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, Tsimberidou AM, Vnencak-Jones CL, Wolff DJ, Younes A, Nikiforova MN (2017) Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. J Mol Diagn 19(1):4–23

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Q, Wang K (2017) InterVar: clinical interpretation of genetic variants by the 2015 ACMG-AMP guidelines. Am J Hum Genet 100(2):267–280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu X, Jian X, Boerwinkle E (2011) dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions. Hum Mutat 32(8):894–899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu X, Wu C, Li C, Boerwinkle E (2016) dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs. Hum Mutat 37(3):235–241

    Article  PubMed  PubMed Central  Google Scholar 

  • Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T, North-East Japan Study Group (2010) Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362(25):2380–2388

    Article  CAS  PubMed  Google Scholar 

  • Mateo J, Chakravarty D, Dienstmann R, Jezdic S, Gonzalez-Perez A, Lopez-Bigas N, Ng CKY, Bedard PL, Tortora G, Douillard JY, Van Allen EM, Schultz N, Swanton C, André F, Pusztai L (2018) A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Ann Oncol 29(9):1895–1902

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meric-Bernstam F, Johnson A, Holla V, Bailey AM, Brusco L, Chen K, Routbort M, Patel KP, Zeng J, Kopetz S, Davies MA, Piha-Paul SA, Hong DS, Eterovic AK, Tsimberidou AM, Broaddus R, Bernstam EV, Shaw KR, Mendelsohn J, Mills GB (2015) A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst 107(7):djv098

    Article  PubMed  PubMed Central  Google Scholar 

  • Mock A, Heilig CE, Kreutzfeldt S, Huebschmann D, Heining C, Schröck E, Brors B, Stenzinger A, Jäger D, Schlenk R, Glimm H, Fröhling S, Horak P, DKTK MASTER Network (Apostolidis L, Augustin M, Aust D, Bhatti I, Bloehdorn J, Brendel C, Britschgi C, Braess J, Burdach S, Busch E, Casuscelli J, Desuki A, Deutsch T, Dietrich M, Ehmer U, Ettrich T, Falkenhorst J, Fehm T, Flörcken A, Forschner A, Fuxius S, Gonzales-Carmona M, Griesinger F, Grill S, Gröschel S, Haag M, Haag U, Halama N, Hebart H, Heidger N, Hermes B, Hess G, Hettmer S, Hoechstetter M, Hoffmann M, Hüttner F, Illert AL, Jenzer M, Kasper B, Kasper-Virchow S, Kindler T, Koscielniak E, Krönke J, Kühn M, Kunzmann V, Lang A, Leichsenring J, Livingstone E, Liotta L, Luley K, Mack E, Martens U, Metzeler K, Middeke JM, Möhrmann L, Jayarama-Naidu R, Pape UF, Perkhofer L, Pfeufer A, Pixberg C, Quante M, Rendenbach B, Rieke D, Rothermundt C, Sagerer AN, Salzmann M, Saur D, Schilling B, Schleicher J, Schlenska-Lange A, Schmidt T, Schmitz S, Schölch S, Shah R, Shoumariyeh K, Siebenhüner A, Singh M, Siveke J, Springfeld C, Starke H, Strobel S, Teleanu V, Thon N, Wagner S, Walle T, Westphalen B, Whitlock B, Winkler E, Wirsik NM, Woydack L, Zabel-du Bois A, Zschäbitz S) (2019) Community-driven development of a modified progression-free survival ratio for precision oncology. ESMO Open 4(6):e000583

    Article  PubMed  PubMed Central  Google Scholar 

  • Park JJH, Siden E, Zoratti MJ, Dron L, Harari O, Singer J, Lester RT, Thorlund K, Mills EJ (2019) Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols. Trials 20(1):572

    Article  PubMed  PubMed Central  Google Scholar 

  • Rehmat N, Farooq H, Kumar S, ul Hussain S, Naveed H (2020) Predicting the pathogenicity of protein coding mutations using Natural Language Processing. In: 42nd annual international conference of the IEEE engineering in medicine & biology society (EMBC), Montreal, S 5842–584

    Google Scholar 

  • Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, Chiarion-Sileni V, Drucis K, Krajsova I, Hauschild A, Lorigan P, Wolter P, Long GV, Flaherty K, Nathan P, Ribas A, Martin AM, Sun P, Crist W, Legos J, Rubin SD, Little SM, Schadendorf D (2015) Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 372(1):30–39

    Article  PubMed  Google Scholar 

  • Schwaederle M, Zhao M, Lee JJ, Eggermont AM, Schilsky RL, Mendelsohn J, Lazar V, Kurzrock R (2015) Impact of precision medicine in diverse cancers: a meta-analysis of phase II clinical trials. J Clin Oncol 33(32):3817–3825. https://doi.org/10.1200/JCO.2015.61.5997. Epub 2015 Aug 24. PMID: 26304871; PMCID: PMC4737863

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sherry ST, Ward M, Sirotkin K (1999) dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome Res 9(8):677–679

    Article  CAS  PubMed  Google Scholar 

  • Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29(1):308–311

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singer J, Irmisch A, Ruscheweyh HJ, Singer F, Toussaint NC, Levesque MP, Stekhoven DJ, Beerenwinkel N (2019) Bioinformatics for precision oncology. Brief Bioinform 20(3):778–788

    Article  CAS  PubMed  Google Scholar 

  • Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F, PROFILE 1014 Investigators (2014) First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371(23):2167–2177

    Article  PubMed  Google Scholar 

  • Starlinger J, Pallarz S, Ševa J, Rieke D, Sers C, Keilholz U, Leser U (2018) Variant information systems for precision oncology. BMC Med Inform Decis Mak 18(1):107

    Article  PubMed  PubMed Central  Google Scholar 

  • Stenzinger A, Edsjö A, Ploeger C, Friedman M, Fröhling S, Wirta V, Seufferlein T, Botling J, Duyster J, Akhras M, Thimme R, Fioretos T, Bitzer M, Cavelier L, Schirmacher P, Malek N, Rosenquist R; GMS Working Groups and ZPM Working Groups (2021) Trailblazing precision medicine in Europe: a joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany. Semin Cancer Biol S1044-579X(21)00156-5. https://doi.org/10.1016/j.semcancer.2021.05.026. Epub ahead of print. PMID: 34033893

  • Tamborero D, Dienstmann R, Rachid MH, Boekel J, Baird R, Braña I, De Petris L, Yachnin J, Massard C, Opdam FL, Schlenk R, Vernieri C, Garralda E, Masucci M, Villalobos X, Chavarria E, Calvo F, Fröhling S, Eggermont A, Apolone G, Voest EE, Caldas C, Tabernero J, Ernberg I, Rodon J, Lehtiö J, Cancer Core Europe Consortium (2020) Support systems to guide clinical decision-making in precision oncology: the Cancer Core Europe Molecular Tumor Board Portal. Nat Med 26(7):992–994. https://doi.org/10.1038/s41591-020-0969-2. PMID: 32632195

    Article  CAS  PubMed  Google Scholar 

  • Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R (2020) Review of precision cancer medicine: evolution of the treatment paradigm. Cancer Treat Rev 86:102019. https://doi.org/10.1016/j.ctrv.2020.102019. Epub 2020 Mar 31. PMID: 32251926; PMCID: PMC7272286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Unberath P, Mahlmeister L, Reimer N, Busch H, Boerries M, Christoph J (2022) Searching of Clinical Trials Made Easier in cBioPortal Using Patients’ Genetic and Clinical Profiles. Appl Clin Inform 13(2):363–369. https://doi.org/10.1055/s-0042-1743560. Epub 2022 Mar 30. PMID: 35354211; PMCID: PMC8967483

  • Van Allen EM, Wagle N, Stojanov P, Perrin DL, Cibulskis K, Marlow S, Jane-Valbuena J, Friedrich DC, Kryukov G, Carter SL, McKenna A, Sivachenko A, Rosenberg M, Kiezun A, Voet D, Lawrence M, Lichtenstein LT, Gentry JG, Huang FW, Fostel J, Farlow D, Barbie D, Gandhi L, Lander ES, Gray SW, Joffe S, Janne P, Garber J, MacConaill L, Lindeman N, Rollins B, Kantoff P, Fisher SA, Gabriel S, Getz G, Garraway LA (2014) Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med 20(6):682–688

    Article  PubMed  PubMed Central  Google Scholar 

  • Wagner AH, Kiwala S, Coffman AC, McMichael JF, Cotto KC, Mooney TB, Barnell EK, Krysiak K, Danos AM, Walker J, Griffith OL, Griffith M (2020) CIViCpy: a python software development and analysis toolkit for the CIViC knowledgebase. JCO Clin Cancer Inform 4:245–253

    Article  PubMed  Google Scholar 

  • Wehrle J, Philipp U, Jolic M, Follo M, Hussung S, Waldeck S, Deuter M, Rassner M, Braune J, Rawluk J, Greil C, Waller CF, Becker H, Duque-Afonso J, Illert AL, Fritsch RM, Meiss F, Duyster J, von Bubnoff N, Scherer F (2020) Personalized treatment selection and disease monitoring using circulating tumor DNA profiling in real-world cancer patient management. Diagnostics (Basel) 10(8):550

    Article  CAS  PubMed  Google Scholar 

  • Westphalen CB, Bokemeyer C, Büttner R, Fröhling S, Gaidzik VI, Glimm H, Hacker UT, Heinemann V, Illert AL, Keilholz U, Kindler T, Kirschner M, Schilling B, Siveke JT, Schroeder T, Tischler V, Wagner S, Weichert W, Zips D, Loges S (2020) Conceptional framework for precision cancer medicine in Germany – consensus statement of the DKH working group „Molecular Diagnostics and Therapy“. Eur J Cancer 135:1–7

    Article  PubMed  Google Scholar 

  • Yepes AJ, MacKinlay A, Gunn N, Schieber C, Faux N, Downton M, Goudey B, Martin RL (2018 Dec) A hybrid approach for automated mutation annotation of the extended human mutation landscape in scientific literature. AMIA Annu Symp Proc 5(2018):616–623

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Medizinische Bioinformatik und Systemmedizin, Universitätsklinikum Freiburg, Freiburg, Deutschland

    Melanie Boerries

  2. Klinik für Innere Medizin I, Hämatologie, Onkologie und Stammzelltransplantation, Universitätsklinikum Freurg, Freiburg, Deutschland

    Anna L. Illert

Authors
  1. Melanie Boerries
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna L. Illert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Melanie Boerries .

Editor information

Editors and Affiliations

  1. Klinik für Urologie, Universitätsklinikum Mannheim, Mannheim, Deutschland

    Maurice Stephan Michel

  2. Klinik für Urologie, Universitätsklinik Mannheim, Mainz, Deutschland

    Joachim W. Thüroff

  3. Abt. für Urologie, Universitätsklinikum Salzburg, Salzburg, Österreich

    Günter Janetschek

  4. Klinik und Poliklinik für Urologie, Univer Tech Univ Dresden, Dresden, Deutschland

    Manfred P. Wirth

Section Editor information

  1. Urologische und Kinderurologische Klinik, Universitätsklinikum Erlangen, Erlangen, Germany

    Bernd Wullich

  2. Klinik für Urologie, Universitätsklinikum Marburg, Philipps Universität Marburg, Marburg, Germany

    Johannes Huber

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Boerries, M., Illert, A.L. (2023). Precision Oncology: Grundlagen und Klassifikationen. In: Michel, M.S., W. Thüroff, J., Janetschek, G., Wirth, M.P. (eds) Die Urologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63400-4_249

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-63400-4_249

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-63399-1

  • Online ISBN: 978-3-662-63400-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation