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Pickering Emulsions for Controlled Drug Delivery to the Skin

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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Emulsions stabilized by solid particles in place of emulsifiers are known as Pickering emulsions. The dense coating made of solid particles adsorbed at the surface of emulsion droplets provides specific properties that strongly influence the transfer of drugs from emulsion droplets to the skin. After a short review about physicochemical properties of Pickering emulsions, the skin delivery of drugs controlled by Pickering emulsions is discussed with the help of examples. Further, possible mechanisms by which such emulsions contribute to drug transport and/or accumulation in the skin are discussed. Penetration-enhancing activity specific to Pickering emulsions comes from the adhesion of droplets onto the skin surface, allowing the transfer of loaded drug molecules to the skin. Application of Pickering emulsions for topical delivery of drugs and cosmetics may be quite a direct implementation of already existing manufacturing processes of classical emulsions.

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Authors and Affiliations

  1. Laboratoire d’Automatique et de Génie des Procédés (LAGEP), CNRS UMR 5007, University of Lyon, Université Claude Bernard Lyon 1, 43 bd 11 Novembre, Villeurbanne, 69622, France

    Yves Chevalier, Marie-Alexandrine Bolzinger & Stéphanie Briançon

Authors
  1. Yves Chevalier
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  2. Marie-Alexandrine Bolzinger
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  3. Stéphanie Briançon
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Correspondence to Yves Chevalier .

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Editors and Affiliations

  1. Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Chevalier, Y., Bolzinger, MA., Briançon, S. (2015). Pickering Emulsions for Controlled Drug Delivery to the Skin. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45013-0_19

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  • DOI: https://doi.org/10.1007/978-3-662-45013-0_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45012-3

  • Online ISBN: 978-3-662-45013-0

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