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Chemistry and Structure-Activity Relationships of Biguanides

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Oral Antidiabetics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 119))

Abstract

In 1878–1879, Rathke obtained a new compound in very low yield via a condensation reaction of thiourea and phosphorus trichloride (which are cyanamide generators) with guanidine.

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Authors
  1. E. Prugnard
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  2. M. Noel
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Editors and Affiliations

  1. Institut für Klinische Pharmakologie, Bayer AG, Aprather Weg, 42096, Wuppertal, Germany

    Jochen Kuhlmann

  2. Krummacher Straße 200, 42115, Wuppertal, Germany

    Walter Puls

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Prugnard, E., Noel, M. (1996). Chemistry and Structure-Activity Relationships of Biguanides. In: Kuhlmann, J., Puls, W. (eds) Oral Antidiabetics. Handbook of Experimental Pharmacology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09127-2_10

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  • DOI: https://doi.org/10.1007/978-3-662-09127-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-62456-1

  • Online ISBN: 978-3-662-09127-2

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