Skip to main content
SpringerLink
Log in

Haemodynamic effects of antihypertensive agents in man

  • Conference paper
Mild Hypertension

  • 43 Accesses

Abstract

The haemodynamic effects of drugs affecting the neutral control of blood pressure in humans can be considered from various standpoints. A long list could be produced of antihypertensive agents acting wholly or partly through the sympathetic nervous system. It would include some drugs not formerly recognized as being in this category (e.g. the diuretics and perhaps even the calcium antagonists). Such drugs cause changes in the peripheral circulation and in the neuromodulation of hormones (such as renin and antidiuretic hormone) which are important in the control of blood pressure and blood volume. The relationship between the clinical effects of these drugs in man and their modes and sites of action in animals is also a matter of considerable interest. This paper, however, concentrates on the effects of antihypertensive drugs on neural cardiovascular regulation and blood pressure homoeostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Mancia G, Ferrari A, Gregorini L, Bianchini C, Terzoli L, Leonetti G, Zauchetti A (1980) Methyldopa and neural control of circulation in essential hypertension. Am J Cardiol 45: 1237–1243.

    Article  PubMed  CAS  Google Scholar 

  2. Ramirez AJ, Bertinieri G, Belli L, Cavallazzi A, Di Rienzo M, Pedotti A, Mancia G: Reflex control of blood pressure and heart rate by arterial baroreceptor, and by cardiopulmonary receptors in the unanaesthetized cat. Submitted for publication.

    Google Scholar 

  3. Korner PI, Oliver JR, Sleight P, Chalmers JP, Robinson JS (1974) Effects of clonidine on the baroreceptor, heart rate reflex and on single aortic baroreceptor fibre discharge. Europ J Pharmacol 20: 189–198.

    Article  Google Scholar 

  4. Parati G, Pomidossi G, Grassi G, Gavazzi C, Ramirez A, Gregorini L, Mancia G (1983) Mechanisms of antihypertensive action of beta-adrenergic blocking drugs: evidence against potentiation of baroreflexes. Europ Heart J Suppl D, 4: 19–25.

    CAS  Google Scholar 

  5. Bristow SD, Honour AS, Pickering GW, Sleight P, Smyth HS (1969) Diminished baroreflex sensitivity in high blood pressure. Circulation 39: 48–54.

    PubMed  CAS  Google Scholar 

  6. Ludbrook J, Mancia G, Ferrari A, Zauchetti A (1977) The variable pressure neck chamber method for studying the carotid baroreflex in man. Clin Sci Mol Med 53: 165–172.

    PubMed  CAS  Google Scholar 

  7. Mancia G, Ferrari A, Gregorini L, Valentini R, Ludbrook J, Zauchetti A (1977) Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. Circulation Res 41: 309–316.

    PubMed  CAS  Google Scholar 

  8. Mancia G, Ludbrook J, Ferrari A, Gregorini L, Zauchetti A (1978) Baroreceptor reflexes in human hypertension. Circulation Res 43: 170–177.

    PubMed  CAS  Google Scholar 

  9. Ricksten Se, Thoan P (1981) Reflex control of sympathetic nerve activity and heart rate from arterial baroreceptors in conscious normotensive and spontaneously hypertensive cats. Clin Sci 61: 169 s-172 s.

    Google Scholar 

  10. Angell-James JE, George MJ (1978) Carotid sinus baroreceptor control of blood pressure and vascular resistance in experimental cardiovascular disease and hypertension. IRCS Med Sci 6: 160.

    Google Scholar 

  11. Mancia G, Ferrari A, Gregorini L, Zauchetti A (1979) Clonidine and carotid baroreflex in essential hypertension. Hypertension 1: 362–370.

    PubMed  CAS  Google Scholar 

  12. Korner PI (1981) Central nervous. control of autonomic cardiovascular function. Handbook of physiology. The cardiovascular system I. Am Physiol Soc Chap 20: 691–739 ( Washington, DC ).

    Google Scholar 

  13. Mancia G, Parati G, Pomidossi G, Grassi G, Buccino N, Ferrari A, Gregorini L, Rupoli L, Zauchetti A (1982) Modification of arterial baroreflexes by captopril in essential hypertension. Am J Cardiol 49: 1415–1419.

    Article  PubMed  CAS  Google Scholar 

  14. Mancia G, Ferrari A, Gregorini L, Ferrari MC, Bianchini C, Teizoli L, Leonetti G, Zauchetti A (1980) Effects of prazosin on autonomic control of circulation in essential hypertension. Hypertension 2: 700–707

    PubMed  CAS  Google Scholar 

  15. Mancia G (1983) Blood pressure variability at normal and high blood pressure. Chest 83:317 S-320 S.

    Google Scholar 

  16. Ferrari A, Gregorini L, Ferrari MC, Preti L, Mancia G (1981) Digitalis and baroreceptor reflexes in man. Circulation 63: 279–285.

    Article  PubMed  CAS  Google Scholar 

  17. Ferrari A, Bonazzi O, Gregorini L, Gardinini M, Perondi R, Mancia G (1983) Modification of the baroreceptor control of atrio-ventricular conduction induced by digitalis in man. Cardiovascular Res 17: 633–641.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Clinica Medica IV, Universita di Milano, Via F. Sforza, 35, 20122, Milano, Italy

    Professor G. Mancia

Authors
  1. A. Zanchetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Professor G. Mancia
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hypertension Center, Veterans Administration Center, 5901 East 7th Street, 90822, Long Beach, California, USA

    M. A. Weber

  2. Medical Unit, St. Mary’ Hospital Medical School, Norfolk Place, W2 1PG, London, Great Britain

    C. J. Mathias M. B., B. S., D. Phil., M. R. C. P. (Senior Wellcome Fellow in Clinical Science, Honorary Consultant Physician and Senior Lecturer in Medicine) (Senior Wellcome Fellow in Clinical Science, Honorary Consultant Physician and Senior Lecturer in Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

About this paper

Cite this paper

Zanchetti, A., Mancia, G. (1984). Haemodynamic effects of antihypertensive agents in man. In: Weber, M.A., Mathias, C.J. (eds) Mild Hypertension. Steinkopff. https://doi.org/10.1007/978-3-642-85334-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85334-0_5

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85336-4

  • Online ISBN: 978-3-642-85334-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation