Zusammenfassung
Maligne Erkrankungen treten in jugendlichem Alter nur relativ selten auf. Im Zeitraum von 1980-1989 wurde bei insgesamt 247 Frauen im Alter zwischen 20 und 35 Jahren in Freiburg ein Malignom diagnostiziert. Lediglich bei 20 Patientinnen bestand zum Zeitpunkt der Diagnose eine Schwangerschaft. Damit errechnete sich eine Koinzidenz von Schwangerschaft und Malignom von 0,07% im oben genannten Beobachtungszeitraum in Freiburg. Diese Daten stimmen mit epidemiologischen Daten in der Literatur überein. (Tab. 1) (27, 41, 44, 50, 52). Eine medikamentöse Tumortherapie in der Schwangerschaft ist nur sehr selten erforderlich. Tritt allerdings eine solche Situation ein, dann ist dies ein vielschichtiges Problem sowohl für die Patientin und deren Familie als auch für den behandelnden Arzt. Im folgenden soll anhand eigener als auch anhand der in der Literatur mitgeteilten Erfahrungen ein Entscheidungsmodell-Modell entwickelt werden, welches dem behandelnden Arzt in Anpassung an die therapeutischen Optionen und das jeweilige Schwangerschaftsalter Richtlinien für eine optimale Therapieempfehlung an die Hand geben möchte.
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Literatur
Alegre, A., Chunchuretta, R., Rodriguez-Alarcon, J., Cruz, E., Prada, M.: Successful pregnancy in acute promyelocytic leukemia Cancer 49, 152–153, 1982.
Andrieu, J.M., Ochoa-Molina, M.E.: Menstrual cycle, pregnancies and offspring after MOPP therapy for Hodgkin’s disease Cancer 52, 435–438, 1983.
Awidi, A.S:, Tarawneh, M.S., Shubair, K.S., Issa, A.A., Dajani, Y.F.: Acute leukemia in pregnancy: Report of five cases treated with a combination with included a low dose of Adriamycin Eur. J. CAncer. Clin. Oncol. 19, 881–884, 1983.
Bartsch, H.H., Meyer, D., Teichmann, A.T., Speer, C.R: Treatment of promyelocytic leukemia during pregnancy Blut 57, 51–54, 1988.
Berrebi, A., Schattner, A., Mogilner, B.M.: Disseminated Burkitt’s lymphoma during pregnancy Acta haemat. 70, 139–140, 1983.
Blatt, J., Mulvihill, J.J., Ziegler, J.L., Young, R.C., Poplack, D.G.: Pregnancy outcome following cancer chemotherapy Am. J. Med. 69, 828–832, 1980.
Blatt, J., Bleyer, W.A.: Late effects of childhood cancer and its treatment In: Pizzo, A.P, Poplack, D.G. (eds): Principles andpractic oncology. 1003–1025, 1989.
Boike, G.M., Deppe, G., Young, J.D. et al.: Chemotherapy in a pregnant rat model: Mitomycin-C. Gynecol. Oncol. 34, 187–190, 1989.
Boros, S.J., Reynolds, J.W.: Intrauterine growth retardation following third-trimester exposure to busulfan Am. J. Obstet. Gynecol. 129, 111–112, 1977.
Burnier, A.M.: Letter Am. J. Obstet Gynecol. 143, 42–43, 1982.
Cantini, E., Yanes, B.: Acute myelogenous leukemia in pregnancy South. Med. J. 77, 1050–1052, 1984.
Carcassonne, Y., Dodemant, P., Favre, R.: Hodgkin’s disease and pregnancy Acta Haemat. 66, 67–68,1981.
Chrisman, J.E., Teng, N.N.H., Lebovic, G.S., Sikic, B.I.: Delivery of a normal infant following Cisplatin, Vinsblatine and Bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy Gynecol. Oncol. 37, 292–295, 1990.
D’Incalci, M., Sessa, C., Colombo, N.: Transplacental passage of Cyclophosphamide Cancer Treat. Rep. 66, 1681–1682, 1982.
Daly, H., McCann, S.R., Hanratty, T.D, Temperley, I.J.: Successful pregnancy during combination chemotherapy for Hodgkin’s disease Acta heamat 64, 154–156, 1980.
Dara, P., Slater, L.M., Armentrout, A.: Successful pregnancy during chemotherapy for acute leukemia Cancer 47, 845–846, 1981.
Doll, D.C., Ringenberg, Q.S., Yarbo, J.W.: Antineoplasics agents and pregnancy Semin Oncol. 16, 337–346, 1989.
DuBois, A., Runge, M., Schmidt, J., Hillemanns, H.G: Disseminiertes, hochmalignes Non- Hodgkin-Lymphom (NHL) und Schwangerschaft: Polychemotherapie in 2. und 3. Trimester Geburtshilfe und Frauenheilk. 50, 405–409, 1990.
Engert, A., Lathan, B., Cremer, R., Seeber, S., Schulte, M., Diehl, V.: Non-Hodgkin-Lymphom und Schwangerschaft Med. Klin. 85, 734–738, 1990.
Falkson, H.C, Simson, I.W, Falkson, G.: Non-Hodgkin’s Lymphoma in pregnancy Cancer 45, 1679–1682, 1980.
Fassas, A., Kartalis, G., Klearchou, N., Tsatalas, K., Sinacos, Z., Mantalenakis, S., Chemotherapy for acute leukemia during pregnancy: Five case report Nouv. Rev. Fr. Hematol. 26, 19–24, 1984.
Feliu, J., Juarez, S., Ordonez, A., Garcia-Peredes, M.L., Gonzales-Baron, M., Montero, J.M.: Acute leukemia and pregnancy Cancer 61, 580–584, 1988.
Garcia, V., San Miguel, J., Borrasca, A.L.: Doxorubicin in the first trimester of pregnancy Ann. Intern. Med. 94, 547, 1981.
Garg, A., Kochupillai, V.: Non-Hodgkin’s lymphoma in pregnancy South. Med. J. 78, 1263–1264, 1985.
Gondo, H., Hamasaki, Y., Nakayama, H. et al.: Acute leukemia during pregnancy: Association with immune-mediated thrombocytopenia in mother and infant Acta haematol. 83, 140–144, 1990.
Grohard, P., Akbaraly, J.P., Saux, M.C. et al.: Passage transplacentaire dela doxorubicine J. Gynecol. Obstet. Biol. Reprod. 18, 229–235, 1984.
Haas, J.F.: Pregnancy in association with the newly diagnosed cancer: a populationbased api- demiologic assessment Int. J. Cancer 34, 229–235, 1984.
Haerr, R.W., Pratt, A.T.: Multiagent chemotherapy for sarcoma diagnosed during pregnancy Cancer 56, 1028–1033, 1985.
Jacobs, R.W, Donaldson, S.S., Rosenberg, S.A, Kaplan, H.S.: Mamagement of the pregnant patient with Hodgkin’s disease Ann. Inter. Med. 95, 669–675, 1981.
Jacobs, A.S., Marchevsky, A, Gordon, R.E, Deppe, G., Cohen, C.J.: Oat cell carcinoma of the uterine cervix in a pregnant women treated with cis-Diamminedichlorplatinum Gynecol. Oncol. 9, 405–410, 1980.
Kalter, H., Warkany, J.: Congenital malformations: Etiologic factors and their role in prevention N. Engl. J. Med. 308, 423–431, 1983.
Karp, G.I., v.Oeyen, P., Valone, F. et al.: Doxorubicin in pregnancy: Possible transplacental passage Cancer Treat. Rep. 67, 773–777, 1983.
King, L.A., Nevin, P., Williams, P.P., Carson, L.F.: Treatment of advanced epithelial ovarian carcinoma in pregnancy with cisplatin-based chemotherapy Gynecol. Oncol. 41, 78–80, 1991.
Malfetano, J.H., Goldkrand, J.W.: Cis-platinum combination chemotherapy during pregnancy for advanced epithelial ovarian carcinoma Obstet Gynecol. 75, 545–547, 1990.
Malone, J.M., Gershenson, D.M., Creasy, R.K., Kavanagh, J.J., Silva, E.G, Stringer, C.A.: Endodermal sinus tumor of the ovary associated with pregnancy Obstet. Gynecol. 68, 86–89, 1986.
Mulvihill, J.J., McKeen, E.A., Rosner, F., Zarrabi, M.H.: Pregnancy outcome in cancer patients: Experience in a large cooperative group Cancer 60, 1143–1152, 1987.
Murray, C.I., Reichert, J.A., Anderson, J., Twiggs, L.B.: Multimodal cancer therapy for breast cancer in the first trimester of pregnancy JAMA 252, 2607–2608, 1984.
Nicholson, H.O.: Cytotoxic drugs in pregnancy. Review of reported cases J. Obstet. Gynecol. Brit. Cwlth. 75, 307–312, 1988.
Parente, J.T., Amsel, M., Lerner, R., Chinea, F.: Breast cancer associated with pregnancy Obstet Gynecol. 71, 861–864, 1988.
Patel, M., Dukes, I.A.F., Hull, J.C.: Use of hydroxyurea in chronic myeloid leukemia during pregnancy: A case report Am. J. Obstet. Gynecol. 165, 565–566, 1991.
Pepe, F., Pepe, G., Guarnuto, V., Isanguine, G., Bianca, G., Garozzo, G.: Cancero e gravidanza. Studio retrospettivo sulla frequenza in 57.393 parti Giorn. Ital. Oncol. 2–3, 77–79, 1989.
Pizzuto, J., Aviles, A., Noriega, L., Niz, J., Morales, M., Romero, F.: Treatment of acute leukemia during pregnancy: Presentation of nine cases Cancer Treat. Rep. 64, 679–683, 1980.
Plows, C.W.: Acute myelomonocytic leukemia in pregnancy: Report of a case Am. J. Obstet. 143, 41–43, 1982.
Potter, J.F., Schoenemann, M.: Metastasis of maternal cancer to the placenta and fetus cancer 25,380–388, 1970.
Raffles, A.,Williams, J., Costeloe, K., Clark, P.: Transplacental effects of maternal cancer chemotherapy. Case report Br. J. Obstet. Gynaecol 69, 1099–1100, 1989.
Reynoso, E.E., Shepherd, F.A., Messner, H.A., Farquharson, H.A., Garvey, M.B., Baker, M.A.: Acute leukemia during pregnancy: The Toronto Leukemia Study Group experience with long-term following up of children exposed in utero to chemotherapeutic agents J. Clin. Oncol. 5, 1098–1106, 1987.
Schaison, G., Jacquillat, C., Auclerc, G., Weil, M.: Les riques feto-embryonnaires des chimo therapies Bull. Cancer 66, 165–170, 1979.
Schapira, D.V, Chudley, A.E.: Successful pregnancy following continuous treatment with combination chemotherapy before conception and troughout pregnancy cancer 54, 800–803, 1984.
Schleuning, M., Clemm, C.: Chromosol aberrations in a newborn whose mother recieved cytotoxic during pregnancy N. Engl. J. Med. 317, 1666–1667, 1987.
Schräge, R.: Krebsregister Baden-Württemberg 1985–1986 Krebsverband Baden-Württemberg e.V. Stuttgart.
Sigler, E., Varon, D., Lugassy, G., Skurnik, Y., Borenstein, R., Berrebi, A.: Favorable outcome in T-Cell acute lymphoblastic leukemia with mediastinal mass during pregnancy Am. J. 85, 125–126, 1988.
Statistisches Amt des Saarlandes. Morbidität und Mortalität an bösartigen Neubildungen im Saarland 1982–1988. Jahresbericht des Saarländischen Krebsregisters. Saarbrücke 1984–1991, Bd. 125, 129, 133, 137, 14.
Sweet, D.L., Kinzie, J:. Consequences of radiotherapy and antineoplastic therapy for the fetus J. Reprod. Med. 17, 241–246, 1976.
Taylor, G., Blom, J.: Acute leukemia during pregnancy South Med. J. 73, 1314–1315, 1980.
Turchi, J.J., Villasis, C.: Anthracyclines inthe treatment of malignancy in pregnancy Cancer 61,435–440, 1988.
Webb, G.A.: The use of hyperalimentation and chemotherapy in pregnancy: A case report Am. J. Obstet. Gynecol. 137, 263–266, 1980.
Wiesner-Bornstein, R., Niesen, M., Grobe-Einsler, R., Schulte -Holtey, M.: Zytostatika-Therapie bei Morbus Hodgkin in der Schwangerschaft Geburtshilfe und Frauenheilk. 43, 373–376, 1983.
Willense, P.H.H., van der Sude, R., Sleijfer, D.T.: Conbimation chemotherapy and radiation for stage IV breast cancer during pregnancy Gynecol. Oncol. 36, 281–284, 1990.
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du Bois, A., Meerpohl, H.G., Gerner, K. (1993). Medikamentöse Tumortherapie in der Schwangerschaft: Wann und Wie?. In: Krebs, D., Berg, D. (eds) Gynäkologie und Geburtshilfe 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77857-5_257
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