Abstract
Adipose tissue plays a major role in caloric homeostasis by shifting between lipid mobilization and storage. Its primary functions can be summarized as follows:
-
1.
Hydrolysis of circulating triglycerides combined with plasma proteins in the form of lipoproteins and uptake of fatty acids thus released.
-
2.
Glucose uptake and utilization for the synthesis of lipids.
-
3.
Lipid storage mainly in the form of triglycerides.
-
4.
Lipolysis and fat mobilization.
Keywords
- Antilipolytic Effect
- Free Fatty Acid Metabolism
- Lipolytic Response
- Lipolytic Process
- Drug Affecting Lipid Metabolism
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Armstrong KJ, Stouffer JE (1974) Effects of thyroid hormone deficiency on cyclic adenosine 3′:5′-monophosphate and control of lipolysis in fat cells. J Biol Chem 249:4226–4231
Caparrotta L, Fassina G, Gaion RM, Tessari F (1983) Age related changes in the antilipolytic effects of nicotinic acid in rat adipose tissue. Br J Pharmacol 80:663–670
Carpene C, Berlan M, Lafontan M (1983) Influence of development and reduction of fat stores on the antilipolytic α2 -adrenoceptor in hamster adipocytes: comparison with adenosine and β-adrenergic receptors. J Lipid Res 24:766–774
Chang WC, Roth GS (1981) Changes in prostaglandin E1 stimulation of glucose oxidation in rat adipocytes during maturation and aging. Life Sci 28:623–627
Cooper B, Gregerman RI (1976) Hormone-sensitive fat cell adenylate cyclase in the rat: influence of growth, cell size, and aging. J Clin Invest 57:161–168
DiGirolamo M, Owens JL, Patrik JG, Kuo JF (1977) Protein kinase activity of isolated rat adipocytes as related to cell size. Proc Soc Exp Biol Med 154:513–516
Forn JN, Schonhofer S, Skidmore IF, Krishna G (1970) Effect of aging on the adenylate cyclase and phosphodiesterase activity in isolated fat cells of rat. Biochim Biophys Acta 208:304–309
Hartman AD (1977) Lipoprotein lipase distribution in rat adipose tissue: effect on chylomicron uptake. Am J Physiol 232:E316–E323
Hartman AD, Cohen AI, Richane CJ, Hsu T (1971) Lipolytic response and adenyl cyclase activity in rat adipocytes as related to cell size. J Lipid Res 12:498–505
Hoffman BB, Chang H, Farahbakhsh ZT, Reaven GM (1984) Age-related decrement in hormone-stimulated lipolysis. Am J Physiol 247:E772–E777
Holm G, Jacobson B, Björntorp P, Smith U (1975) Effects of age and cell size on rat adipose tissue metabolism. J Lipid Res 16:461–464
Krishna G, Hynie S, Brodie BB (1968) Effects of thyroid hormones on adenyl cyclase in adipose tissue and on free fatty acid metabolism. Proc Natl Acad Sci 59:884–889
Lafontan M (1979) Inhibition of epinephrine-induced lipolysis in isolated while adipocytes of aging rabbits by increased alpha-adrenergic responsiveness. J Lipid Res 20:208–216
Malbon CC (1980) The effects of thyroid status on the modulation of fat cell β-adrenergic receptor agonist affinity gy guanine nucleotides. Mol Pharmacol 18:193–198
Masoro EJ, Bertrand H, Liepa G, Yu BP (1979) Analysis and exploration of age-related changes in mammalian structure and function. Fed Proc 38:1956–1961
Olefsky JM (1976) The effects of spontaneous obesity in insulin binding, glucose transport and glucose oxidation in isolated rat adipocytes. J Clin Invest 57:842–851
Olefsky JM (1977) Insensitivity of large rat adipocytes to the antilipolytic effects of insulin. J Lipid Res 18:459–464
Rosenqvist U, Efendic S (1971) Stimulatory effect in vitro of prostaglandin E1 on noradrenaline-induced lipolysis in subcutaneous adipose tissue from hypothyroid subjects. Acta Med Scand 190:341–345
Westgren U, Burger A, Ingemansson S, Melander A, Tibblin S, Wahlin E (1976) Blood levels of 3,5,3′-triiodothyronine and thyroxine: differences between children, adults and elderly subjects. Acta Med Scand 200:493–495
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Gaion, R.M., Dorigo, P. (1987). Lipolysis and Antilipolytic Drugs at Different Ages. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-71702-4_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71704-8
Online ISBN: 978-3-642-71702-4
eBook Packages: Springer Book Archive