Skip to main content
SpringerLink
Log in

Unerwünschte Transfusionswirkungen

  • Chapter
  • First Online:
Transfusionspraxis

  • 3052 Accesses

Zusammenfassung

Blutkomponenten unterscheiden sich grundlegend von klassischen Arzneimitteln, denn jede Blutkomponente ist eine individuelle Präparation aus Spenderblut mit spezifischen biologischen Merkmalen. Zelluläre und plasmatische Antigene und Antikörper können beim Transfusionsempfänger Nebenwirkungen auslösen, ohne dass das Präparat aus pharmazeutischer Sicht einen Qualitätsmangel aufweist. Die Einschätzung und Bewertung des Risikos unerwünschter Wirkungen und die Entwicklung von Maßnahmen zur Risikoreduktion hängen entscheidend von der systematischen Überwachung (Hämovigilanz) mit Hilfe eines Meldesystems ab. Zentraler Bestandteil der Hämovigilanz ist die Beobachtung und Meldung von Reaktionen, damit aus diesen Daten Maßnahmen zur weiteren Erhöhung der Sicherheit bei der Hämotherapie entwickelt werden können.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur und Internetadressen

  • Amato A et al. (2011) Perioperative blood transfusions and recurrence of colorectal cancer (Review). The Cochrane Library Issue 2. Available at http://www.thecochranelibrary.com

  • Busch O et al. (1993) Blood transfusions and prognosis in colorectal cancer. N Engl J Med 328:1372–6

    Article  CAS  PubMed  Google Scholar 

  • Busch O et al. (1993) Prognostic impact of blood transfusions on disease-free survival in colorectal carcinoma. Scand J Gastroenterol Suppl 200:21–3

    Article  CAS  PubMed  Google Scholar 

  • Deitenbeck R (2012) Der besondere Fall – Posttransfusionspurpura (PTP) als mögliche Nebenwirkung der Transfusion zellulärer Blutkomponenten: Eine Fallbeschreibung. Hämotherapie 18: 40–44. www.drk-haemotherapie.de

  • Dixon B et al. (2013) The association of blood transfusion with mortality after cardiac surgery: cause or confounding? Transfusion 53:19–27

    Article  PubMed  Google Scholar 

  • Gatermann S (2011) Pathogenecity of bacteria contaminating blood products. Transfus Med Hemother 38:236–238

    Article  PubMed Central  PubMed  Google Scholar 

  • Haarlar JJ et al. (2012) Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial. Ann Surg 256:681–6

    Article  Google Scholar 

  • Hajjar LA et al. (2010) Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 304:1559–67

    Article  CAS  PubMed  Google Scholar 

  • Hämovigilanzbericht des Paul-Ehrlich-Instituts 2010: http://www.pei.de/SharedDocs/Downloads/fachkreise/haemovigilanz/publikationen/haemovigillanz-bericht2010,templateld=raw,property=publicationFile.pdf/haemovigillanz-bericht-2010.pdf

  • Heiss MM et al. (1993) Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery. Lancet 342:1328–33. Erratum in: Lancet 343:64

    Google Scholar 

  • Heiss MM et al. (1997) Modulation of immune response by blood transfusion: evidence for a differential effect of allogeneic and autologous blood in colorectal cancer surgery. Shock 8:402–8

    Article  CAS  PubMed  Google Scholar 

  • Heiss MM et al. (1997) Prognostic influence of blood transfusion on minimal residual disease in resected gastric cancer patients. Anticancer Res 17:2657–61

    CAS  PubMed  Google Scholar 

  • Houbiers JG et al. (1994) Randomised controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in sugery for colorectal cancer. Lancet 344:573–578

    Article  CAS  PubMed  Google Scholar 

  • Hourfar MK et al. (2008) Experience of German Red Cross blood donor services with nucleic acid testing: results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus. Transfusion 48:1558–1566

    Article  PubMed  Google Scholar 

  • http://www.akdae.de

  • http://www.pei.de

  • http://www.rki.de

  • http://www.shotuk.org

  • ISBT Working Party on Haemovigilance. Proposed Standard definitions for surveillance of non infectious adverse transfusion reactions. http://www.ihn-org.com

  • Jensen LS et al. (1996) Randomised comparison of leucocyte-depletetd versus buffy-coat-poor blood transfusion and complications after colorectal surgery. Lancet 348:841–845

    Article  CAS  PubMed  Google Scholar 

  • Juhl D et al. Parvovirus B19 infections and blood count in blood donors. Transfus Med Hemother 2014;41:52–59.

    Article  PubMed Central  PubMed  Google Scholar 

  • Liumbruno GM et al. (2010) Old blood, new blood or better stored blood? Editorial Blood Transfus 8:217–219

    Google Scholar 

  • Querschnittsleitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten. 4. überarbeitetet Auflage 2009. Deutscher Ärzteverlag Köln http://baek.de

  • Offergeld R et al. (2010) Die Rolle des Robert-Koch-Instituts im Transfusionswesen. Hämotherapie 14:74–78. www.drk-haemotherapie.de

  • Opelz G et al. (1973) Effect of transfusions on subsequent kidney transplants. Transplant Proc 5:253–259

    CAS  PubMed  Google Scholar 

  • Pagelino JC et al. (2004) Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction. Transfusion 44:16–24

    Article  Google Scholar 

  • Popovsky MA (ed) (2012) Transfusion Reactions, 4th Edition. AABB Press, Bethesda, Maryland

    Google Scholar 

  • Querschnittsleitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten, Bundesärztkammer

    Google Scholar 

  • Reil A et al. (2007) Transfusionsassoziierte akute Lungeninsuffizienz: Eine unterschätzte Nebenwirkung von Bluttransfusionen. Dtsch Ärztebl 104(15):A-1018/B-904/C–860

    Google Scholar 

  • Richtlinien zur Gewinnung von Blut und Blutbestandteilen, Bundesärztekammer, Paul-Ehrlich Institut

    Google Scholar 

  • Savage WJ et al. (2013) Scratching the surface of allergic transfusion reactions. Transfusion 53:1361–1371

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schmidt M et al. (2011) Sicherheit der Blutprodukte – Update 2011. Transfusionsmedizin 1:28–50

    Article  Google Scholar 

  • Seitz R et al. Die Rolle des Paul-Ehrlich-Instituts im Transfusionswesen. Hämotherapie 2010;14:69–73. www.drk-haemotherapie.de

  • Strumper-Groves D (2006) Perioperative blood transfusion and outcome. Curr Opin Anesth 19:196–206

    Article  Google Scholar 

  • The Age of Blood Evaluation (ABLE) Study. Available from: http://www.controlled-trials.com

  • The Age of Red Blood Cells in Premature Infants (A RIPI). Available from: http://www.controlled-trials.com

  • The Red Cell Storage Duration Study (RECESS). Available from: http://clinicaltrials.gov

  • Tobian AA et al. (2011) Prevention of allergic transfusion reactions to platelets and red cells through plasma reduction. Transfusion 51:1676–1683

    Article  PubMed  Google Scholar 

  • Vamvakas EC (2010) Meta-analysis of clinical studies of the purported deletrious effects of ‘‘old‘‘ (versus ‘‘fresh‘‘) red blood cells: are we at equipoise? Transfusion 2010;50:600–610

    Article  PubMed  Google Scholar 

  • Vamvakas EC et al. (2013) Pneumonia as a complication of blood product transfusion in the critically ill: Transfusion-related immunomodulation (TRIM). Crit Care Med 2006;34,No5(Suppl.):151–159

    Google Scholar 

  • van de Watering (2010) Klinische Studien zur Untersuchung von Nebenwirkungen länger gelagerter Erythrozytenkonzentrate. Hämotherapie 15:33–35. www.drk-haemotherapie.de

  • van de Watering JL (2011) Red cell storage and prognosis. Vox Sang 100:36–45

    Article  PubMed  Google Scholar 

  • van de Watering JL et al. (1998) Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery. Circulation 97(6):562–8

    Article  PubMed  Google Scholar 

  • van de Watering JL for the Biomedical Excellence for safer Transfusion (BEST) Collaborative (2011) Pitfalls in the current published observational literature on the effects of red blood cell storage. Transfusion 51:1847–1854

    Article  Google Scholar 

  • Walther-Wenke G et al. (2011) Impact of bacterial contamination on blood supply. Transfus Med Hemother 38:229–230

    Article  PubMed Central  PubMed  Google Scholar 

  • Walther-Wenke G et al. (2011) Monitoring bacterial contamination of blood components in Germany: effect of contamination reduction measures. Vox Sang 100:356–366

    Article  Google Scholar 

  • Ziemann M et al. (2013) The impact of donor cytomegalovirus DNA on transfusion strategies for at-risk patients. Transfusion 53:2183–2189

    Article  PubMed  Google Scholar 

  • Ziemann M et al. (2014) Prevention of transfusion-transmitted Cytomegalo-virus infections: Which is the optimal strategy. Transfus Med 41:40–44

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. DRK Blutspendedienst West, Zentrum für Transfusionsmedizin Münster, Postfach 1767, 48006, Münster, Deutschland

    G. Walther-Wenke

Authors
  1. G. Walther-Wenke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Walther-Wenke .

Editor information

Editors and Affiliations

  1. Soltau, Germany

    Günter Singbartl

  2. Münster, Germany

    Gabriele Walther-Wenke

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Walther-Wenke, G. (2014). Unerwünschte Transfusionswirkungen. In: Singbartl, G., Walther-Wenke, G. (eds) Transfusionspraxis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55428-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55428-5_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-55427-8

  • Online ISBN: 978-3-642-55428-5

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation