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Endogene Cannabinoide und das Endocannabinoidsystem

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Handbuch Psychoaktive Substanzen

Part of the book series: Springer Reference Psychologie ((SRP))

Zusammenfassung

Das Endocannabinoidsystem mit seinen endogenen Cannabinoiden, Cannabinoid- und anderen Rezeptoren sowie Proteinen, die für die Biosynthese und den Abbau von Endocannabinoiden wie Anandamid (N-Arachidonoylethanolamid) und 2-AG (2-Arachidonoylglycerol) verantwortlich sind, übt im zentralen Nervensystem und in vielen anderen Organen wichtige biologische Funktionen aus. Heute sind etwa 200 endocannabinoidähnliche Substanzen bekannt. Störungen der normalen Funktionsweise dieses Neurotransmittersystems können zu Beeinträchtigungen von Organfunktionen führen, wie beispielsweise Störungen der Hirnleistungsfähigkeit, von Fortpflanzungs-, Immun- und Magendarmfunktionen. Seine Hauptfunktion besteht in der Hemmung der Freisetzung anderer Neurotransmitter. Bei Erkrankungen kann eine spezifische Beeinflussung des Endocannabinoidsystems, beispielsweise durch eine Hemmung des Abbaus von Endocannabinoiden oder die Zufuhr pflanzlicher Cannabinoide, die an Cannabinoidrezeptoren binden oder die Konzentration von Endocannabinoiden beeinflussen, von Nutzen sein.

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Authors and Affiliations

  1. Chemiepark Knapsack, nova-Institut GmbH, Industriestr. 300, 50354, Hürth, Deutschland

    Franjo Grotenhermen

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  1. Franjo Grotenhermen
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Correspondence to Franjo Grotenhermen .

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Editors and Affiliations

  1. FINDER academy and research , Berlin, Germany

    Maximilian von Heyden

  2. FINDER academy and research , Berlin, Germany

    Henrik Jungaberle

  3. St. Hedwig Krankenhaus, Charité Universitätsmedizin Berlin St. Hedwig Krankenhaus, Berlin, Berlin, Germany

    Tomislav Majić

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Grotenhermen, F. (2016). Endogene Cannabinoide und das Endocannabinoidsystem. In: von Heyden, M., Jungaberle, H., Majić, T. (eds) Handbuch Psychoaktive Substanzen. Springer Reference Psychologie . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55214-4_39-1

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  • DOI: https://doi.org/10.1007/978-3-642-55214-4_39-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-55214-4

  • Online ISBN: 978-3-642-55214-4

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