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PanVascular Medicine pp 1–32Cite as

Neurosurgery in Ischemic Stroke

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Introduction

Ischemic stroke , in which brain tissue injury results from blood supply insufficient to prevent cell death by inadequate provision of oxygen and nutrients and removal of waste products, accounts for approximately 80 % of all strokes, the remainder being hemorrhagic strokes including intracerebral hemorrhage and subarachnoid hemorrhage (Thrift et al. 2000; Donnan et al. 2008). Typically ischemic stroke is the result of focal arterial occlusion from thrombosis or embolism but may also be secondary to global cerebral hypoperfusion, as in cardiac arrest or hypotension, or secondary to venous thrombosis.

Pathophysiology of Cerebral Ischemia

The mechanisms underlying cell death following cerebral ischemia are now well known. Before describing the events that occur at a microscopic and macroscopic level after ischemia, it is worthwhile considering normal brain tissue metabolism and blood supply.

Normal Brain Metabolism and Substrate Transport

The brain is a highly aerobic organ,...

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References

  • (STAIR) S. T. A. I. R. (1999) Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke J Cereb Circ 30(12):2752–2758

    Google Scholar 

  • Adeeb N, Mortazavi MM et al (2012) The cranial dura mater: a review of its history, embryology, and anatomy. Child’s Nerv Syst 28(6):827–837

    Google Scholar 

  • Albano C, Comandante L et al (2005) Innovations in the management of cerebral injury. Crit Care Nurs Q 28(2):135–149

    PubMed  Google Scholar 

  • Alvarez B, Ferrer-Sueta G et al (1998) Slowing of peroxynitrite decomposition in the presence of mannitol and ethanol. Free Radic Biol Med 24(7–8):1331–1337

    CAS  PubMed  Google Scholar 

  • Amin-Hanjani S (2011) Cerebral revascularization: extracranial-intracranial bypass. J Neurosurg Sci 55(2):107–116

    CAS  PubMed  Google Scholar 

  • Araki Y, Andoh H et al (1999) Permissible arterial occlusion time in aneurysm surgery: postoperative hyperperfusion caused by temporary clipping. Neurol Med Chir 39(13):901–906; discussion 906–907

    CAS  Google Scholar 

  • Arnaout OM, Aoun SG et al (2011) Decompressive hemicraniectomy after malignant middle cerebral artery infarction: rationale and controversies. Neurosurg Focus 30(6):E18

    PubMed  Google Scholar 

  • Astrup J, Siesjo BK et al (1981) Thresholds in cerebral ischemia – the ischemic penumbra. Stroke J Cereb Circ 12(6):723–725

    CAS  Google Scholar 

  • Ausman JI, Diaz FG et al (1985) Current management of cerebral aneurysms: is it based on facts or myths? Surg Neurol 24(6):625–635

    CAS  PubMed  Google Scholar 

  • Bandera E, Botteri M et al (2006) Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review. Stroke J Cereb Circ 37(5):1334–1339

    Google Scholar 

  • Bardutzky J, Schwab S (2007) Antiedema therapy in ischemic stroke. Stroke J Cereb Circ 38(11):3084–3094

    CAS  Google Scholar 

  • Batjer HH, Frankfurt AI et al (1988) Use of etomidate, temporary arterial occlusion, and intraoperative angiography in surgical treatment of large and giant cerebral aneurysms. J Neurosurg 68(2):234–240

    CAS  PubMed  Google Scholar 

  • Becker A, Kuhnt T et al (2002) Oxygenation measurements in head and neck cancers during hyperbaric oxygenation. Strahlentherapie Onkol 178(2):105–108

    Google Scholar 

  • Bell BA (1984) A history of the study of the cerebral circulation and the measurement of cerebral blood flow. Neurosurgery 14(2):238–246

    CAS  PubMed  Google Scholar 

  • Benmira S, Banda ZK et al (2011) The start of a new era for stroke treatment: mechanical thrombectomy devices. Curr Neurovasc Res 8(1):75–85

    PubMed  Google Scholar 

  • Bereczki D, Fekete I et al (2007) Mannitol for acute stroke. Cochrane Database Syst Rev 3:CD001153

    PubMed  Google Scholar 

  • Blanco M, Nombela F et al (2007) Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology 69(9):904–910

    CAS  PubMed  Google Scholar 

  • Bosel J, Hacke W et al (2012) Treatment of acute ischemic stroke with clot retrieval devices. Curr Treat Options Cardiovasc Med 14(3):260–272

    PubMed  Google Scholar 

  • Branston NM, Symon L et al (1974) Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 45(2):195–208

    CAS  PubMed  Google Scholar 

  • Buchthal A, Belopavlovic M et al (1988) Evoked potential monitoring and temporary clipping in cerebral aneurysm surgery. Acta Neurochir 93(1–2):28–36

    CAS  PubMed  Google Scholar 

  • Bulters D, Kirkpatrick P (2011) Intracranial cerebral revascularization. J Neurosurg Sci 55(2):97–105

    CAS  PubMed  Google Scholar 

  • Carmichael ST (2005) Rodent models of focal stroke: size, mechanism, and purpose. NeuroRx 2(3):396–409

    PubMed Central  PubMed  Google Scholar 

  • Carvi y Nievas M, Toktamis S et al (2005) Hyperacute measurement of brain-tissue oxygen, carbon dioxide, pH, and intracranial pressure before, during, and after cerebral angiography in patients with aneurysmatic subarachnoid hemorrhage in poor condition. Surg Neurol 64(4):362–367; discussion 367

    PubMed  Google Scholar 

  • Cerejo A, Silva PA et al (2011a) Monitoring of brain oxygenation in surgery of ruptured middle cerebral artery aneurysms. Surg Neurol Int 2:70

    PubMed Central  PubMed  Google Scholar 

  • Cerejo A, Silva PA et al (2011b) Monitoring of brain tissue oxygenation in surgery of middle cerebral artery incidental aneurysms. Surg Neurol Int 2:37

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chan KH, Dearden NM et al (1992) Transcranial Doppler waveform differences in hyperemic and nonhyperemic patients after severe head injury. Surg Neurol 38(6):433–436

    CAS  PubMed  Google Scholar 

  • Charbel FT, Ausman JI et al (1991) Temporary clipping in aneurysm surgery: technique and results. Surg Neurol 36(2):83–90

    CAS  PubMed  Google Scholar 

  • Cho DY, Chen TC et al (2003) Ultra-early decompressive craniectomy for malignant middle cerebral artery infarction. Surg Neurol 60(3):227–232; discussion 232–223

    PubMed  Google Scholar 

  • Collaboration, S. U. T. (2007) Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev 4:CD000197

    Google Scholar 

  • Czosnyka M, Pickard JD (2004) Monitoring and interpretation of intracranial pressure. J Neurol Neurosurg Psychiatry 75(6):813–821

    CAS  PubMed Central  PubMed  Google Scholar 

  • Czosnyka M, Smielewski P et al (2007) Intracranial pressure: more than a number. Neurosurg Focus 22(5):E10

    PubMed  Google Scholar 

  • Davidson LSP (1956) Principles and practice of medicine. Livingstone, Edinburgh

    Google Scholar 

  • Degracia DJ (2010) Towards a dynamical network view of brain ischemia and reperfusion. Part III: therapeutic implications. J Exp Stroke Transl Med 3(1):90–103

    PubMed Central  PubMed  Google Scholar 

  • den Hertog HM, van der Worp HB et al (2009) The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol 8(5):434–440

    Google Scholar 

  • Dennis MS, Lewis SC et al (2005) Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial. Lancet 365(9461):764–772

    CAS  PubMed  Google Scholar 

  • Dennis M, Sandercock PA et al (2009) Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial. Lancet 373(9679):1958–1965

    PubMed  Google Scholar 

  • Diringer MN, Zazulia AR (2004) Osmotic therapy: fact and fiction. Neurocrit Care 1(2):219–233

    CAS  PubMed  Google Scholar 

  • Dirnagl U, Kaplan B et al (1989) Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model. J Cereb Blood Flow Metab: Off J Int Soc Cereb Blood Flow Metab 9(5):589–596

    CAS  Google Scholar 

  • Doerfler A, Forsting M et al (1996) Decompressive craniectomy in a rat model of “malignant” cerebral hemispheric stroke: experimental support for an aggressive therapeutic approach. J Neurosurg 85(5):853–859

    CAS  PubMed  Google Scholar 

  • Donnan GA, Fisher M et al (2008) Stroke. Lancet 371(9624):1612–1623

    CAS  PubMed  Google Scholar 

  • Duthie SE, Goulin GD et al (1994) Effects of THAM and sodium bicarbonate on intracranial pressure and mean arterial pressure in an animal model of focal cerebral injury. J Neurosurg Anesthesiol 6(3):201–208

    CAS  PubMed  Google Scholar 

  • Ebinger M, De Silva DA et al (2009) Imaging the penumbra – strategies to detect tissue at risk after ischemic stroke. J Clin Neurosci 16(2):178–187

    CAS  PubMed  Google Scholar 

  • Edvinsson L, MacKenzie ET et al (1993) Cerebral blood flow and metabolism. Raven, New York

    Google Scholar 

  • Eftekhar B, Morgan MK (2011) Indications for the use of temporary arterial occlusion during aneurysm repair: an institutional experience. J Clin Neurosci 18(7):905–909

    PubMed  Google Scholar 

  • Erecinska M, Silver IA (2001) Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 128(3):263–276

    CAS  PubMed  Google Scholar 

  • Ferch R, Pasqualin A et al (2002) Temporary arterial occlusion in the repair of ruptured intracranial aneurysms: an analysis of risk factors for stroke. J Neurosurg 97(4):836–842

    PubMed  Google Scholar 

  • Fieschi C, Bozzao L et al (1964) Regional measurements of cerebral blood blow by recording in depth of hydrogen “clearance” curves. Boll Soc Ital Biol Sper 40(23):1505–1509

    CAS  PubMed  Google Scholar 

  • Fieschi C, Bozzao L et al (1965) Regional clearance of hydrogen as a measure of cerebral blood flow. Acta Neurol Scand Suppl 14:46–52

    CAS  PubMed  Google Scholar 

  • Foerch C, Otto B et al (2004) Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion. Stroke J Cereb Circ 35(9):2160–2164

    CAS  Google Scholar 

  • Forsting M, Reith W et al (1995) Decompressive craniectomy for cerebral infarction. An experimental study in rats. Stroke J Cereb Circ 26(2):259–264

    CAS  Google Scholar 

  • Foundation NS (2010) Clinical guidelines for stroke management 2010. Australian Government, National Health and Medical Research Council, Melbourne

    Google Scholar 

  • Gelabert-González M, Fernandez-Villa JM et al (2002) Intra-operative monitoring of brain tissue O2 (PtiO2) during aneurysm surgery. Acta Neurochir 144(9):863–866; discussion 866–867

    PubMed  Google Scholar 

  • Georgiadis D, Schwarz S et al (2001) Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach. Stroke J Cereb Circ 32(11):2550–2553

    CAS  Google Scholar 

  • Georgiadis D, Schwarz S et al (2002) Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke. Stroke J Cereb Circ 33(6):1584–1588

    CAS  Google Scholar 

  • Giles TL, Lasserson TJ et al (2006) Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev 3:CD001106

    PubMed  Google Scholar 

  • Go KG (1997) The normal and pathological physiology of brain water. Adv Tech Stand Neurosurg 23:47–142

    CAS  PubMed  Google Scholar 

  • Gonzalez RG, Schaefer PW et al (1999) Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 210(1):155–162

    CAS  PubMed  Google Scholar 

  • Griffiths PD, Hoggard N et al (2001) In vivo measurement of cerebral blood flow: a review of methods and applications. Vasc Med 6(1):51–60

    CAS  PubMed  Google Scholar 

  • Group, T. N. I. o. N. D. a. S. r.-P. S. S. (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333(24):1581–1587

    Google Scholar 

  • Ha SK, Lim DJ et al (2009) Risk of stroke with temporary arterial occlusion in patients undergoing craniotomy for cerebral aneurysm. J Korean Neurosurg Soc 46(1):31–37

    PubMed Central  PubMed  Google Scholar 

  • Hacke W, Kaste M et al (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA: J Am Med Assoc 274(13):1017–1025

    CAS  Google Scholar 

  • Hacke W, Schwab S et al (1996) ‘Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol 53(4):309–315

    CAS  PubMed  Google Scholar 

  • Hacke W, Donnan G et al (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363(9411):768–774

    PubMed  Google Scholar 

  • Hacke W, Kaste M et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359(13):1317–1329

    CAS  PubMed  Google Scholar 

  • Hawkins BT, Davis TP (2005) The blood–brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57(2):173–185

    CAS  PubMed  Google Scholar 

  • Heinsius T, Bogousslavsky J et al (1998) Large infarcts in the middle cerebral artery territory. Etiology and outcome patterns. Neurology 50(2):341–350

    CAS  PubMed  Google Scholar 

  • Heiss WD (1983) Flow thresholds of functional and morphological damage of brain tissue. Stroke J Cereb Circ 14(3):329–331

    CAS  Google Scholar 

  • Hemphill JC 3, Morabito D et al (2005) Brain tissue oxygen monitoring in intracerebral hemorrhage. Neurocrit Care 3(3):260–270

    PubMed  Google Scholar 

  • Hevner RF, Liu S et al (1995) A metabolic map of cytochrome oxidase in the rat brain: histochemical, densitometric and biochemical studies. Neuroscience 65(2):313–342

    CAS  PubMed  Google Scholar 

  • Hill M, Martin RH et al (2012) Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol 11(11):942–950

    CAS  PubMed  Google Scholar 

  • Hoelper BM, Alessandri B et al (2005) Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors. Acta Neurochir 147(7):767–774; discussion 774

    CAS  PubMed  Google Scholar 

  • Hofmeijer J, van der Worp HB et al (2003) Treatment of space-occupying cerebral infarction. Crit Care Med 31(2):617–625

    PubMed  Google Scholar 

  • Hofmeijer J, Amelink GJ et al (2006) Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction. Trials 7:29

    PubMed Central  PubMed  Google Scholar 

  • Hutchinson P, Timofeev I et al (2007) Surgery for brain edema. Neurosurg Focus 22(5):E14

    PubMed  Google Scholar 

  • Imberti R, Bellinzona G et al (2002) Cerebral tissue PO2 and SjvO2 changes during moderate hyperventilation in patients with severe traumatic brain injury. J Neurosurg 96(1):97–102

    PubMed  Google Scholar 

  • Ingvar DH (1961) Quantitative measurement of regional metabolism, pO2, and pCO2 in the cerebral cortex. Neurology 11(4 Pt 2):68–71

    PubMed  Google Scholar 

  • Jabre A, Symon L (1987) Temporary vascular occlusion during aneurysm surgery. Surg Neurol 27(1):47–63

    CAS  PubMed  Google Scholar 

  • Jaeger M, Soehle M et al (2005) Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen. Acta Neurochir 147(1):51–56; discussion 56

    CAS  PubMed  Google Scholar 

  • Janardhan V, Qureshi AI (2004) Mechanisms of ischemic brain injury. Curr Cardiol Rep 6(2):117–123

    PubMed  Google Scholar 

  • Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet 1(7905):480–484

    CAS  PubMed  Google Scholar 

  • Jodicke A, Hubner F et al (2003) Monitoring of brain tissue oxygenation during aneurysm surgery: prediction of procedure-related ischemic events. J Neurosurg 98(3):515–523

    PubMed  Google Scholar 

  • Johnson RD, Maartens NF et al (2011) Decompressive craniectomy for malignant middle cerebral artery infarction: evidence and controversies. J Clin Neurosci 18(8):1018–1022

    PubMed  Google Scholar 

  • Jones TH, Morawetz RB et al (1981) Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 54(6):773–782

    CAS  PubMed  Google Scholar 

  • Juttler E, Schwab S et al (2007) Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke J Cereb Circ 38(9):2518–2525

    Google Scholar 

  • Kasner SE, Demchuk AM et al (2001) Predictors of fatal brain edema in massive hemispheric ischemic stroke. Stroke J Cereb Circ 32(9):2117–2123

    CAS  Google Scholar 

  • Kelly J, Hunt BJ et al (2004) Dehydration and venous thromboembolism after acute stroke. QJM: Mon J Assoc Phys 97(5):293–296

    CAS  Google Scholar 

  • Kernohan JW, Woltman HW (1972) Incisura of the crus due to contralateral brain tumor. Arch Neurol Psychiatr 21:274–287

    Google Scholar 

  • Kett-White R, Hutchinson PJ et al (2002) Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction. J Neurosurg 96(6):1013–1019

    PubMed  Google Scholar 

  • Kety SS (1949) Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J 38(3):321–328

    CAS  PubMed  Google Scholar 

  • Kety SS (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3(1):1–41

    CAS  PubMed  Google Scholar 

  • Kety SS, Schmidt CF (1945) The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol 143:53–66

    CAS  Google Scholar 

  • Khatri R, McKinney AM et al (2012) Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke. Neurology 79(13 Suppl 1):S52–S57

    PubMed  Google Scholar 

  • Kiening KL, Unterberg AW et al (1996) Monitoring of cerebral oxygenation in patients with severe head injuries: brain tissue PO2 versus jugular vein oxygen saturation. J Neurosurg 85(5):751–757

    CAS  PubMed  Google Scholar 

  • Kirmani JF, Alkawi A et al (2012) Advances in thrombolytics for treatment of acute ischemic stroke. Neurology 79(13 Suppl 1):S119–S125

    CAS  PubMed  Google Scholar 

  • Kleinschnitz C (2012) Kallikrein/Kinin-System mediated cell-cell interactions of the blood–brain-barrier after ischemic insult. http://www.sfb688.uni-wuerzburg.de/en/project_areas/area_a/area_aii/a13_kleinschnitz/. Retrieved 24 Jan 2013

  • Koennecke HC, Belz W et al (2011) Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology 77(10):965–972

    PubMed  Google Scholar 

  • Kollmar R, Schwab S (2007) Ischaemic stroke: acute management, intensive care, and future perspectives. Br J Anaesth 99(1):95–101

    CAS  PubMed  Google Scholar 

  • Korenkov AI, Pahnke J et al (2000) Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev 23(3):145–150

    CAS  PubMed  Google Scholar 

  • Krieger D, Adams HP et al (1992) Pure motor hemiparesis with stable somatosensory evoked potential monitoring during aneurysm surgery: case report. Neurosurgery 31(1):145–150

    CAS  PubMed  Google Scholar 

  • Landau WM, Freygang WH Jr et al (1955) The local circulation of the living brain; values in the unanesthetized and anesthetized cat. Trans Am Neurol Assoc (80th Meeting):125–129

    Google Scholar 

  • Lang EW, Mulvey JM et al (2007) Direct cerebral oxygenation monitoring–a systematic review of recent publications. Neurosurg Rev 30(2):99–106; discussion 106–107

    PubMed  Google Scholar 

  • Langfitt TW, Weinstein JD et al (1964) Transmission of Increased Intracranial Pressure. I. Within the Craniospinal Axis. J Neurosurg 21:989–997

    CAS  PubMed  Google Scholar 

  • Lansberg MG, Bluhmki E et al (2009) Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. Stroke J Cereb Circ 40(7):2438–2441

    CAS  Google Scholar 

  • Lanzino G, Kassell NF et al (1996) Age and outcome after aneurysmal subarachnoid hemorrhage: why do older patients fare worse? J Neurosurg 85(3):410–418

    CAS  PubMed  Google Scholar 

  • Lavine SD, Masri LS et al (1997) Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection. J Neurosurg 87(6):817–824

    CAS  PubMed  Google Scholar 

  • Levy DE, Van Uitert RL et al (1979) Delayed postischemic hypoperfusion: a potentially damaging consequence of stroke. Neurology 29(9 Pt 1):1245–1252

    CAS  PubMed  Google Scholar 

  • Lim J, Lasserson TJ et al (2004) Oral appliances for obstructive sleep apnoea. Cochrane Database Syst Rev 4:CD004435

    PubMed  Google Scholar 

  • Lindekleiv H (2005) Neurosurgery in antique medicine. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 125(24):3494–3496

    Google Scholar 

  • Ljunggren B, Saveland H et al (1983) Temporary clipping during early operation for ruptured aneurysm: preliminary report. Neurosurgery 12(5):525–530

    CAS  PubMed  Google Scholar 

  • Macdonald RL, Stoodley M (1998) Pathophysiology of cerebral ischemia. Neurol Med Chir 38(1):1–11

    CAS  Google Scholar 

  • Mackey WC (2010) The role of carotid revascularization in stroke prevention. Perspect Vasc Surg Endovasc Ther 22(1):7–15

    PubMed  Google Scholar 

  • Magnaes B (1976a) Body position and cerebrospinal fluid pressure. Part 1: clinical studies on the effect of rapid postural changes. J Neurosurg 44(6):687–697

    CAS  PubMed  Google Scholar 

  • Magnaes B (1976b) Body position and cerebrospinal fluid pressure. Part 2: clinical studies on orthostatic pressure and the hydrostatic indifferent point. J Neurosurg 44(6):698–705

    CAS  PubMed  Google Scholar 

  • Maher F, Vannucci SJ et al (1994) Glucose transporter proteins in brain. FASEB J 8(13):1003–1011

    CAS  PubMed  Google Scholar 

  • Manninen PH, Lam AM et al (1987) The effect of high-dose mannitol on serum and urine electrolytes and osmolality in neurosurgical patients. Can J Anaesth 34(5):442–446

    CAS  PubMed  Google Scholar 

  • Marcoux FW, Morawetz RB et al (1982) Differential regional vulnerability in transient focal cerebral ischemia. Stroke J Cereb Circ 13(3):339–346

    CAS  Google Scholar 

  • Margaritescu O, Mogoanta L et al (2009) Histopathological changes in acute ischemic stroke. Rom J Morphol Embryol 50(3):327–339

    PubMed  Google Scholar 

  • Markus HS (2004) Cerebral perfusion and stroke. J Neurol Neurosurg Psychiatry 75(3):353–361

    CAS  PubMed Central  PubMed  Google Scholar 

  • Marmarou A, Beaumont A (2011) Physiology of the cerebrospinal fluid and intracranial pressure. In: Winn HR (ed) Youmans neurological surgery, vol 1. Elsevier Saunders, Philadelphia, pp 169–182

    Google Scholar 

  • Masamoto K, Tanishita K (2009) Oxygen transport in brain tissue. J Biomech Eng 131(7):074002

    PubMed  Google Scholar 

  • Mayer SA (2007) Hemicraniectomy: a second chance on life for patients with space-occupying MCA infarction. Stroke J Cereb Circ 38(9):2410–2412

    Google Scholar 

  • Mayer SA, Kowalski RG et al (2004) Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit Care Med 32(12):2508–2515

    PubMed  Google Scholar 

  • Mazzeo AT, Bullock R (2007) Monitoring brain tissue oxymetry: will it change management of critically ill neurologic patients? J Neurol Sci 261(1–2):1–9

    PubMed  Google Scholar 

  • McCormick PW, Stewart M et al (1991) Regional cerebrovascular oxygen saturation measured by optical spectroscopy in humans. Stroke J Cereb Circ 22(5):596–602

    CAS  Google Scholar 

  • McEwen BS, Reagan LP (2004) Glucose transporter expression in the central nervous system: relationship to synaptic function. Eur J Pharmacol 490(1–3):13–24

    CAS  PubMed  Google Scholar 

  • McInnes E, Bell-Syer SE et al (2008) Support surfaces for pressure ulcer prevention. Cochrane Database Syst Rev 4:CD001735

    PubMed  Google Scholar 

  • McNealy DE, Plum P (1962) Brain stem dysfunction with supratentorial mass lesions. Arch Neurol Psychiatr 7:10–32

    Google Scholar 

  • Meyer A (1920) Herniation of the brain. Arch Neurol Psychiatr 4:387–400

    Google Scholar 

  • Meyer FB, Anderson RE et al (1986) Intracellular brain pH, indicator tissue perfusion, electroencephalography, and histology in severe and moderate focal cortical ischemia in the rabbit. J Cereb Blood Flow Metab 6(1):71–78

    CAS  PubMed  Google Scholar 

  • Milhaud D, Thouvenot E et al (2005) Prolonged moderate hypothermia in massive hemispheric infarction: clinical experience. J Neurosurg Anesthesiol 17(1):49–53

    PubMed  Google Scholar 

  • Minnerup J, Sutherland BA et al (2012) Neuroprotection for stroke: current status and future perspectives. Int J Mol Sci 13(9):11753–11772

    CAS  PubMed Central  PubMed  Google Scholar 

  • Momma F, Wang AD et al (1987) Effects of temporary arterial occlusion on somatosensory evoked responses in aneurysm surgery. Surg Neurol 27(4):343–352

    CAS  PubMed  Google Scholar 

  • Morawetz RB, DeGirolami U et al (1978) Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke J Cereb Circ 9(2):143–149

    CAS  Google Scholar 

  • Moskowitz MA, Lo EH et al (2010) The science of stroke: mechanisms in search of treatments. Neuron 67(2):181–198

    CAS  PubMed Central  PubMed  Google Scholar 

  • Moustafa RR, Baron JC (2008) Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery. Br J Pharmacol 153(Suppl 1):S44–S54

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mulvey JM, Dorsch NW et al (2004) Multimodality monitoring in severe traumatic brain injury: the role of brain tissue oxygenation monitoring. Neurocrit Care 1(3):391–402

    PubMed  Google Scholar 

  • Nagao S, Kitaoka T et al (1996) Effect of tris-(hydroxymethyl)-aminomethane on experimental focal cerebral ischemia. Exp Brain Res Exp Hirnforsch Exp Cereb 111(1):51–56

    CAS  Google Scholar 

  • Ndubuizu O, LaManna JC (2007) Brain tissue oxygen concentration measurements. Antioxid Redox Signal 9(8):1207–1219

    CAS  PubMed  Google Scholar 

  • Nemani VM, Manley GT (2004) Brain tissue oxygen monitoring: physiological principles and clinical application. Oper Tech Neurosurg 7(1):2–9

    Google Scholar 

  • O’Brien MD, Jordan MM et al (1974) Ischemic cerebral edema and the blood–brain barrier. Distributions of pertechnetate, albumin, sodium, and antipyrine in brains of cats after occlusion of the middle cerebral artery. Arch Neurol 30(6):461–465

    PubMed  Google Scholar 

  • O’Collins VE, Macleod MR et al (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59(3):467–477

    PubMed  Google Scholar 

  • Oddo M, Le Roux P (2008) Brain tissue oxygen monitors: more than an ischemia monitor. Crit Care Med 36(6):1984–1985

    PubMed  Google Scholar 

  • Ogawa A, Sato H et al (1991) Limitation of temporary vascular occlusion during aneurysm surgery. Study by intraoperative monitoring of cortical blood flow. Surg Neurol 36(6):453–457

    CAS  PubMed  Google Scholar 

  • Ogilvy CS, Carter BS et al (1996) Temporary vessel occlusion for aneurysm surgery: risk factors for stroke in patients protected by induced hypothermia and hypertension and intravenous mannitol administration. J Neurosurg 84(5):785–791

    CAS  PubMed  Google Scholar 

  • Ohmoto T, Nagao S et al (1991) Monitoring of cortical blood flow during temporary arterial occlusion in aneurysm surgery by the thermal diffusion method. Neurosurgery 28(1):49–54; discussion 54–45

    CAS  PubMed  Google Scholar 

  • Olsen TS (1986) Regional cerebral blood flow after occlusion of the middle cerebral artery. Acta Neurol Scand 73(4):321–337

    CAS  PubMed  Google Scholar 

  • Oppenheim C, Samson Y et al (2000) Prediction of malignant middle cerebral artery infarction by diffusion-weighted imaging. Stroke J Cereb Circ 31(9):2175–2181

    CAS  Google Scholar 

  • Pasztor E, Symon L et al (1973) The hydrogen clearance method in assessment of blood flow in cortex, white matter and deep nuclei of baboons. Stroke J Cereb Circ 4(4):556–567

    CAS  Google Scholar 

  • Penchet G, Arne P et al (2007) Use of intraoperative monitoring of somatosensory evoked potentials to prevent ischaemic stroke after surgical exclusion of middle cerebral artery aneurysms. Acta Neurochir 149(4):357–364

    CAS  PubMed  Google Scholar 

  • Poca MA, Benejam B et al (2010) Monitoring intracranial pressure in patients with malignant middle cerebral artery infarction: is it useful? J Neurosurg 112(3):648–657

    PubMed  Google Scholar 

  • Pollock LJ, Boshes B (1936) Cerebrospinal fluid pressure. Arch Neurol Psychiatr 36(5):931–974

    Google Scholar 

  • Pool JL (1961a) Aneurysms of the anterior communicating (ACC) artery–indications for surgery. Trans Am Neurol Assoc 86:232–233

    CAS  PubMed  Google Scholar 

  • Pool JL (1961b) Aneurysms of the anterior communicating artery. Bifrontal craniotomy and routine use of temporary clips. J Neurosurg 18:98–112

    CAS  PubMed  Google Scholar 

  • Qizilbash N, Lewington SL et al (2002) Corticosteroids for acute ischaemic stroke. Cochrane Database Syst Rev 2:CD000064

    PubMed  Google Scholar 

  • Righetti E, Celani MG et al (2004) Glycerol for acute stroke. Cochrane Database Syst Rev 2:CD000096

    PubMed  Google Scholar 

  • Rink C, Khanna S (2011) Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke. Antioxid Redox Signal 14(10):1889–1903

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ritter AM, Robertson CS (1994) Cerebral metabolism. Neurosurg Clin N Am 5(4):633–645

    CAS  PubMed  Google Scholar 

  • Rohrer MJ, Natale AM (1992) Effect of hypothermia on the coagulation cascade. Crit Care Med 20(10):1402–1405

    CAS  PubMed  Google Scholar 

  • Ronning OM, Guldvog B (1999) Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke J Cereb Circ 30(10):2033–2037

    CAS  Google Scholar 

  • Rosenthal G, Hemphill JC 3rd et al (2008) Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med 36(6):1917–1924

    CAS  PubMed  Google Scholar 

  • Rosner MJ, Coley IB (1986) Cerebral perfusion pressure, intracranial pressure, and head elevation. J Neurosurg 65(5):636–641

    CAS  PubMed  Google Scholar 

  • Rosner MJ, Rosner SD et al (1995) Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg 83(6):949–962

    CAS  PubMed  Google Scholar 

  • Rudolph AM, Heymann MA (1967) The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21(2):163–184

    CAS  PubMed  Google Scholar 

  • Ryder HW, Espey FF et al (1951) Observations on the interrelationships of intracranial pressure and cerebral blood flow. J Neurosurg 8(1):46–58

    CAS  PubMed  Google Scholar 

  • Samson D, Batjer HH et al (1994) A clinical study of the parameters and effects of temporary arterial occlusion in the management of intracranial aneurysms. Neurosurgery 34(1):22–28; discussion 28–29

    CAS  PubMed  Google Scholar 

  • Sandercock PA, Counsell C et al (2008a) Antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev 3:CD000029

    PubMed  Google Scholar 

  • Sandercock PA, Counsell C et al (2008b) Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke. Cochrane Database Syst Rev 3:CD000119

    PubMed  Google Scholar 

  • Schramm J, Koht A et al (1990) Surgical and electrophysiological observations during clipping of 134 aneurysms with evoked potential monitoring. Neurosurgery 26(1):61–70

    CAS  PubMed  Google Scholar 

  • Schurr A (2002) Lactate, glucose and energy metabolism in the ischemic brain (review). Int J Mol Med 10(2):131–136

    CAS  PubMed  Google Scholar 

  • Schwab S, Aschoff A et al (1996) The value of intracranial pressure monitoring in acute hemispheric stroke. Neurology 47(2):393–398

    CAS  PubMed  Google Scholar 

  • Schwab S, Schwarz S et al (1998a) Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke J Cereb Circ 29(12):2461–2466

    CAS  Google Scholar 

  • Schwab S, Steiner T et al (1998b) Early hemicraniectomy in patients with complete middle cerebral artery infarction. Stroke J Cereb Circ 29(9):1888–1893

    CAS  Google Scholar 

  • Schwab S, Georgiadis D et al (2001) Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke J Cereb Circ 32(9):2033–2035

    CAS  Google Scholar 

  • Schwarz S, Georgiadis D et al (2002) Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke. Stroke J Cereb Circ 33(2):497–501

    Google Scholar 

  • Shorr AF, Jackson WL et al (2008) Differences between low-molecular-weight and unfractionated heparin for venous thromboembolism prevention following ischemic stroke: a metaanalysis. Chest 133(1):149–155

    CAS  PubMed  Google Scholar 

  • Silva PA, Cerejo A et al (2012) Regional variations in brain oxygenation during temporary clipping in aneurysm surgery. Neurol Res 34(10):971–976

    CAS  PubMed  Google Scholar 

  • Simard JM, Chen M et al (2006) Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. Nat Med 12(4):433–440

    CAS  PubMed Central  PubMed  Google Scholar 

  • Simard JM, Tsymbalyuk N et al (2010) Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke. Stroke J Cereb Circ 41(3):531–537

    CAS  Google Scholar 

  • Sims NR, Muyderman H (2010) Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta 1802(1):80–91

    CAS  PubMed  Google Scholar 

  • Skvarilova B, Povysil C et al (2007) Trephinations–old surgical intervention. Acta Chir Plast 49(4):103–108

    CAS  PubMed  Google Scholar 

  • Steiner T, Weber R et al (2001) Increased intracerebral pressure following stroke. Curr Treat Options Neurol 3(5):441–450

    PubMed  Google Scholar 

  • Stosseck K, Lubbers DW et al (1974) Determination of local blood flow (microflow) by electrochemically generated hydrogen. Construction and application of the measuring probe. Pflugers Arch – Eur J Physiol 348(3):225–238

    CAS  Google Scholar 

  • Sutherland BA, Minnerup J et al (2012) Neuroprotection for ischaemic stroke: translation from the bench to the bedside. Int J Stroke 7(5):407–418

    PubMed  Google Scholar 

  • Suzuki J, Kwak R et al (1979) The safe time limit of temporary clamping of cerebral arteries in the direct surgical treatment of intracranial aneurysm under moderate hypothermia. Tohoku J Exp Med 127(1):1–7

    CAS  PubMed  Google Scholar 

  • Symon L (1985) European Association of Neurosurgical Societies Fifth European lecture. Barcelona, February 24, 1984. Thresholds of ischaemia applied to aneurysm surgery. Acta Neurochir 77(1–2):1–7

    CAS  PubMed  Google Scholar 

  • Symon L (1990) Management of giant intracranial aneurysms. Clin Neurosurg 36:21–47

    CAS  PubMed  Google Scholar 

  • Symon L, Pasztor E et al (1974) The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons. Stroke J Cereb Circ 5(3):355–364

    CAS  Google Scholar 

  • Tan CC, Khurana VG et al (2011) Cerebral blood flow and metabolism and cerebral ischemia. In: Winn HR (ed) Youmans neurological surgery, vol 4. Elsevier Saunders, Philadelphia, pp 3537–3562

    Google Scholar 

  • Taylor CL, Selman WR et al (1996) Temporary vessel occlusion during intracranial aneurysm repair. Neurosurgery 39(5):893–905; discussion 905–896

    CAS  PubMed  Google Scholar 

  • Thome C, Vajkoczy P et al (2001) Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery. J Neurosurg 95(3):402–411

    CAS  PubMed  Google Scholar 

  • Thrift AG, Dewey HM et al (2000) Stroke incidence on the east coast of Australia: the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke J Cereb Circ 31(9):2087–2092

    CAS  Google Scholar 

  • Traystman RJ (2004) The paper that completely altered our thinking about cerebral blood flow measurement. J Appl Physiol 97(5):1601–1602

    PubMed  Google Scholar 

  • Treadwell SD, Thanvi B (2010) Malignant middle cerebral artery (MCA) infarction: pathophysiology, diagnosis and management. Postgrad Med J 86(1014):235–242

    PubMed  Google Scholar 

  • Tsai AG, Cabrales P et al (2010) The physics of oxygen delivery: facts and controversies. Antioxid Redox Signal 12(6):683–691

    CAS  PubMed Central  PubMed  Google Scholar 

  • Vahedi K, Hofmeijer J et al (2007a) Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 6(3):215–222

    PubMed  Google Scholar 

  • Vahedi K, Vicaut E et al (2007b) Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke 38(9):2506–2517

    PubMed  Google Scholar 

  • Valadka AB, Gopinath SP et al (1998) Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 26(9):1576–1581

    CAS  PubMed  Google Scholar 

  • van Santbrink H, Maas AI et al (1996) Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38(1):21–31

    PubMed  Google Scholar 

  • Vink R, Bahtia KD et al (2008) The relationship between intracranial pressure and brain oxygenation following traumatic brain injury in sheep. Acta Neurochir Supplement 102:189–192

    Google Scholar 

  • Wagner S, Schnippering H et al (2001) Suboptimum hemicraniectomy as a cause of additional cerebral lesions in patients with malignant infarction of the middle cerebral artery. J Neurosurg 94(5):693–696

    CAS  PubMed  Google Scholar 

  • Wardlaw JM, Murray V et al (2009) Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 4:CD000213

    PubMed  Google Scholar 

  • Washington CW, Zipfel GJ (2011) Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care 15(2):312–317

    PubMed  Google Scholar 

  • Weinstein JD, Langfitt TW et al (1968) Experimental study of patterns of brain distortion and ischemia produced by an intracranial mass. J Neurosurg 28(6):513–521

    CAS  PubMed  Google Scholar 

  • Wilkins R, Wilkins G (2000) Neurosurgical classics II. Thieme

    Google Scholar 

  • Wirtz CR, Steiner T et al (1997) Hemicraniectomy with dural augmentation in medically uncontrollable hemispheric infarction. Neurosurg Focus 2(5):E3; discussion 1 p following E3

    CAS  PubMed  Google Scholar 

  • Wolf AL, Levi L et al (1993) Effect of THAM upon outcome in severe head injury: a randomized prospective clinical trial. J Neurosurg 78(1):54–59

    CAS  PubMed  Google Scholar 

  • Wong-Riley MT (1989) Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci 12(3):94–101

    CAS  PubMed  Google Scholar 

  • Young W (1980) H2 clearance measurement of blood flow: a review of technique and polarographic principles. Stroke J Cereb Circ 11(5):552–564

    CAS  Google Scholar 

  • Zacharia BE, Mocco J et al (2006) J. Lawrence Pool, M.D.: a pioneer in vascular neurosurgery. Neurosurg Focus 20(6):E2

    PubMed  Google Scholar 

  • Zauner A, Doppenberg EM et al (1997) Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery 41(5):1082–1091; discussion 1091–1083

    CAS  PubMed  Google Scholar 

  • Zauner A, Doppenberg E et al (1998) Extended neuromonitoring: new therapeutic opportunities? Neurol Res 20(Suppl 1):S85–S90

    PubMed  Google Scholar 

  • Zivin JA, Fisher M et al (1985) Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science 230(4731):1289–1292

    CAS  PubMed  Google Scholar 

Further Reading

  • York GK 3rd, Steinberg DA (2010) Neurology in ancient Egypt, Chapter 3. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 95. pp 29–36

    Google Scholar 

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Authors and Affiliations

  1. Women’s and Children’s Hospital, Adelaide, Australia

    Adam Wells (Neurosurgery Registrar)

  2. The Royal Adelaide Hospital, Adelaide, Australia

    Amal Abou-Hamden (Staff Specialist, The Royal Adelaide Hospital; Clinical Senior Lecturer, The University of Adelaide)

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  1. Adam Wells
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  2. Amal Abou-Hamden
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  1. Akademisches Lehrkrankenhaus MLU, Bitterfeld-Wolfen, Germany

    Peter Lanzer

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Wells, A., Abou-Hamden, A. (2014). Neurosurgery in Ischemic Stroke. In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37393-0_104-1

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