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Antioxidant Supplementation in Older Persons

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Systems Biology of Free Radicals and Antioxidants

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Abstract

According to the free-radical theory of aging, oxidative stress is a key contributor to the aging process by inducing structural and functional damages to over the lifespan of the organism. Although innate defenses exist to neutralize such detrimental effects, they still are insufficient to counteract the continuous large production of reactive oxygen species. In this context, interventions aimed at reducing/inhibiting the detrimental effects of oxidants and supporting the organism’s defense against oxidative damage may exert positive actions on the conditions and pathophysiological modifications typical of the aging process. Epidemiological data report significant consumption of antioxidant supplementations (in particular, vitamin C, vitamin E, β-carotene, and selenium) in Western countries, in spite of the scarce evidence available to support such widespread use. Moreover, several studies also raise concerns about the safety of this type of intervention. In this chapter, we discuss available evidence related to the use of antioxidant supplements to prevent age-related subclinical and clinical conditions.

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Authors and Affiliations

  1. Institut du Vieillissement, Gérontopôle, Centre Hospitalier Universitaire de Toulouse, 37 Allées Jules Guesde, 31000, Toulouse, France

    Matteo Cesari, Laurent Demougeot & Bruno Vellas

  2. Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Università Cattolica del Sacro Cuore, Rome, Italy

    Francesco Cerullo & Giovanni Gambassi

  3. Hospice “Sacro Cuore”, Roma, Italy

    Valentina Zamboni

  4. Center for Gerontology and Health Care Research, Department of Community Health, Brown University School of Medicine, Providence, RI, USA

    Giovanni Gambassi

  5. Inserm UMR-1027, Université de Toulouse III Paul Sabatier, Toulouse, France

    Matteo Cesari & Bruno Vellas

Authors
  1. Matteo Cesari
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  2. Francesco Cerullo
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  3. Laurent Demougeot
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  4. Valentina Zamboni
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  5. Giovanni Gambassi
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  6. Bruno Vellas
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Correspondence to Matteo Cesari .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Cesari, M., Cerullo, F., Demougeot, L., Zamboni, V., Gambassi, G., Vellas, B. (2014). Antioxidant Supplementation in Older Persons. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_175

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