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Propan-1-ol

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Antiseptic Stewardship

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Abstract

Propan-1-ol has bactericidal activity at 60%. It is effective against C. albicans at 85% in 30 s. Some food-associated fungi require at least 5 min exposure time. A mycobactericidal activity of propan-1-ol has not been described. High MIC values indicating resistance to propan-1-ol have so far not been reported. An epidemiological cut-off value to determine acquired resistance has not been proposed yet. No specific resistance mechanisms are currently known for propan-1-ol, no cross-tolerance to antibiotics has been reported. Low-level propan-1-ol exposure (0.5–4%) can increase biofilm formation in S. epidermidis; 0.2–2% propan-1-ol can increase surface attachment in P. aeruginosa. Biofilm development of C. albicans can be inhibited by 2% propan-1-ol. The effect of propan-1-ol at use concentrations on biofilm development and fixation is unknown. Biofilm removal by 60% propan-1-ol is low in S. epidermidis.

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  1. Institute of Hygiene and Environmental Medicine, University of Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany

    Günter Kampf

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Kampf, G. (2018). Propan-1-ol. In: Antiseptic Stewardship. Springer, Cham. https://doi.org/10.1007/978-3-319-98785-9_3

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