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Pathology of the Orbit: Neoplasms

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Albert and Jakobiec's Principles and Practice of Ophthalmology

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Abstract

Orbital tumors constitute a heterogeneous group of neoplasms. A systemic approach allows for better understanding of their classification and clinical implications. Based on their origin, tumors occurring in the orbit are classified as primary neoplasms, which originate in the orbital structures/tissues themselves; secondary neoplasms, which extend by contiguity to the orbit from adjacent structures such as intracranial tumors and tumors of the paranasal sinuses; and metastatic neoplasms.

The primary orbital neoplasms are divided histologically into tumors of the lacrimal gland, tumors with mesenchymal differentiation, neoplasms arising in the orbital bones, lymphoproliferative and hematopoietic neoplasms, tumors originating in the optic nerve sheath, and tumors of uncertain etiology. In this chapter, classifications were based on the most current World Health Organization classification of tumors. For each neoplasm, we provide diagnostic criteria, based on gross and microscopic features, recommendations for usage of immunohistochemistry, and ancillary molecular testing to assist with the diagnosis and differentiation with other similar neoplasms. A summary of the clinical presentation, prevalence, and clinical behavior is also provided.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA

    Valentina Logunova, Anja C. Roden & Diva R. Salomão

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  1. Valentina Logunova
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  2. Anja C. Roden
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  3. Diva R. Salomão
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Correspondence to Diva R. Salomão .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Oregon Health & Science University Department of Ophthalmology, Portland, OR, USA

    Daniel Albert

  2. Massachusetts Eye and Ear, Boston, MA, USA

    Joan Miller

  3. Department of Ophthalmology, University of Illinois at Chicago Department of Ophthalmology, Chicago, IL, USA

    Dimitri Azar

  4. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Lucy H. Young

Section Editor information

  1. Anatomic Pathology, Massachusetts General Hospital, Boston, USA

    Anna M. Stagner

  2. Ophthalmic Pathology and Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA

    Natalie Wolkow

  3. David Glendenning Cogan Laboratory of Pathology, Harvard Medical School, Boston, USA

    Thaddeus Dryja

  4. David Glendenning Cogan Laboratory of Ophthalmic Pathology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Frederick A. Jakobiec

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Logunova, V., Roden, A.C., Salomão, D.R. (2021). Pathology of the Orbit: Neoplasms. In: Albert, D., Miller, J., Azar, D., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-90495-5_135-1

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