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Transfusion-Related Acute Lung Injury (TRALI)

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Oncologic Critical Care

Abstract

TRALI is an adult respiratory distress syndrome occurring within 6 h of transfusion that presents with fever, cyanosis, dyspnea, and opacity of the pulmonary fields on frontal chest radiograph. TRALI has been described with all blood components, and its mechanism has been associated with donor HLA antibodies and some biologic response modifiers that trigger a leukocyte damage of the lung capillaries leading to leakage of fluid in the alveolar spaces. There is a 20% mortality as consequence of TRALI, and many patients require oxygen support and mechanical ventilation.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Adriana Maria Knopfelmacher

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  1. Adriana Maria Knopfelmacher
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Editors and Affiliations

  1. Department of Critical Care and Respiratory Care, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Joseph L. Nates

  2. Division of Anesthesiology, Critical Care and Pain Medicine, Department of Critical Care and Respiratory Care, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Kristen J. Price

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Knopfelmacher, A.M. (2020). Transfusion-Related Acute Lung Injury (TRALI). In: Nates, J., Price, K. (eds) Oncologic Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-74588-6_108

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  • DOI: https://doi.org/10.1007/978-3-319-74588-6_108

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74587-9

  • Online ISBN: 978-3-319-74588-6

  • eBook Packages: MedicineReference Module Medicine

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