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Sex Hormones and Immunosenescence

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Book cover Handbook of Immunosenescence

Abstract

Sex hormones impact a number of aspects of immunity. As a result of the aging process, dramatic changes occur in the endocrine system, particularly in the sex hormones. Thus, it is possible that the hormonal environment may play a role in the effects of aging on normal aspects of the aging immune system, as well as in immune responses to injury and infection. Although much has been uncovered regarding age-related changes in the immune and the endocrine systems, the exact mechanism of the interplay between these three factors has yet to be resolved. In this chapter, we explore each of these areas and investigate how sex hormones may be an important component to immunosenescence. Finally, the beneficial and adverse effects of hormone replacement therapy on the aging process are discussed. As age and gender are potential modifiers of the disease process, therapies targeted to the specific hormonal and immune status of an individual may prove to be of most benefit for optimal clinical outcomes.

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Acknowledgments

This work was supported by DOD PC094680 (CRG), DOD PC131783 (CRG), PCF Creativity Award (CRG), Hyundai Hope on Wheels Program (CRG), and University of Mississippi Medical Center Office of Research (CRG). National Institutes of Health (NIH) F30 AG029724 (VN). NIH R01 AG018859 (EJK), R01 AA012034 (EJK), R01 GM115257 (EJK), Illinois Excellence in Academic Medicine Grant (EJK), and Ralph and Marion C. Falk Research Trust (EJK). We acknowledge Amit Reddy for editorial support.

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Authors and Affiliations

  1. Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

  2. Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

  3. Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

  4. Department of Surgery, Division of Trauma and Critical Care, University of Cincinnati, Cincinnati, OH, USA

    Vanessa Nomellini

  5. Department of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA

    Elizabeth J. Kovacs

  6. Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, USA

    Elizabeth J. Kovacs

  7. Graduate Program in Immunology, University of Colorado Denver, Aurora, CO, USA

    Elizabeth J. Kovacs

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  1. Christian R. Gomez
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  2. Vanessa Nomellini
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  3. Elizabeth J. Kovacs
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Correspondence to Elizabeth J. Kovacs .

Editor information

Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Gomez, C.R., Nomellini, V., Kovacs, E.J. (2018). Sex Hormones and Immunosenescence. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_42-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_42-1

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