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Tranquilizers/Anxiolytics: Definition, Indications, Contraindications, and Treatment

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NeuroPsychopharmacotherapy

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Abstract

The term “anxiolytics” has been more commonly used recently instead of “tranquilizers” or “minor tranquilizers” to describe this group of substances and medications used in the treatment of states of anxiety, tension, fear, agitation, and anxiety disorders.

Although benzodiazepines are commonly perceived as the main drugs representing this group, other and newer compounds targeting neurobiological and neurotransmitter systems including but not limited to the gamma-aminobutyric acid (GABA) system and the monoaminergic (serotonin/norepinephrine) systems have been increasingly studied and used in clinical practice.

This chapter provides an introduction and overview of the book section “Tranquilizers/Anxiolytics” on current and evolving pharmacological approaches in the treatment of anxiety disorders, anxiety states, and symptoms. Mechanisms of action, pharmacokinetic aspects, indications and contraindications, general information and principles, potential clinical limitations and barriers of treatment with anxiolytic medications, as well as novel agents are summarized.

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Authors and Affiliations

  1. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada

    Stefan Kloiber & Gerasimos Konstantinou

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  1. Stefan Kloiber
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  2. Gerasimos Konstantinou
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Correspondence to Stefan Kloiber .

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Editors and Affiliations

  1. Dept Psychiatry , Psychosomatics & Psychotherapy, University of Würzburg, Medical School Clinical Neurochemistry, Würzburg, Germany

    Peter Riederer

  2. Inst für Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. Würzburg, Bayern, Germany

    Christian Riederer

Section Editor information

  1. Department of Psychiatry, University of Toronto, Toronto, ON, Canada

    Stefan Kloiber

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Kloiber, S., Konstantinou, G. (2021). Tranquilizers/Anxiolytics: Definition, Indications, Contraindications, and Treatment. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_59-1

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