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Prostate Focused Ultrasound Therapy

  • Chapter
Therapeutic Ultrasound

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

The tremendous progress in engineering and computing power coupled with ultrasound transducer technology and imaging modalities over the past 20 years have encouraged a revival of clinical interest in ultrasound therapy, mainly in High-Intensity Focused Ultrasound (HIFU). So far, the most extensive results from HIFU obtained in urology involve transrectal prostate ablation, which appears to be an effective therapeutic alternative for patients with malignant prostate tumors. Prostate cancer (PCa) is one of the most frequently diagnosed cancers in men. Several treatment options with different therapeutic approaches exist, including HIFU for localized PCa that has been in use for over 15 years. Since the early 2000s, two systems have been marketed for this application, and other devices are currently in clinical trials. HIFU treatment can be used either alone or in combination with (before- or after-) external beam radiotherapy (EBRT) (before or after HIFU) and can be repeated multiple times. HIFU treatment is performed under real-time monitoring with ultrasound or guided by MRI. Two indications are validated today: Primary care treatment and EBRT failure. The results of HIFU for primary care treatment are similar to standard conformal EBRT, even though no randomized comparative studies have been performed and no 10-year follow up data is yet available for HIFU. Salvage HIFU after EBRT failure is increasing with oncological outcomes, similar to those achieved with surgery but with the advantage of fewer adverse effects. HIFU is an evolving technology perfectly adapted for focal treatment. Thus, HIFU focal therapy is another pathway that must be explored when considering the accuracy and reliability for PCa mapping techniques. HIFU would be particularly suited for such a therapy since it is clear that HIFU outcomes and toxicity are relative to the volume of prostate treated.

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Notes

  1. 1.

    http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics

  2. 2.

    The authors published some materials of this book chapter in 2012 in Chapter 6 of “Management of Prostate, A Multidisciplinary Approach”. Springer, Bolla, Michel, van Poppel, Hendrik (Eds.), 2012, pp.191–212.

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Authors and Affiliations

  1. INSERM, U1032, Lyon, F-69003, France

    Jean-Yves Chapelon, Olivier Rouvière, Sébastien Crouzet & Albert Gelet

  2. Laboratory of Therapeutic Applications of Ultrasound, Université Lyon 1, Lyon, France

    Jean-Yves Chapelon, Olivier Rouvière, Sébastien Crouzet & Albert Gelet

  3. Department of Radiology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France

    Olivier Rouvière

  4. Department of Urology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France

    Sébastien Crouzet & Albert Gelet

Authors
  1. Jean-Yves Chapelon
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  2. Olivier Rouvière
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  3. Sébastien Crouzet
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  4. Albert Gelet
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Corresponding author

Correspondence to Jean-Yves Chapelon .

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Editors and Affiliations

  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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Chapelon, JY., Rouvière, O., Crouzet, S., Gelet, A. (2016). Prostate Focused Ultrasound Therapy. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_2

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