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Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways

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Protein Kinase CK2 Cellular Function in Normal and Disease States

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 12))

Abstract

Near simultaneously with the explosive expansion in the understanding of CK2’s prodigious promiscuity, the kinase was and has been implicated in a large number of cancers through a variety of mechanisms. Over the past few years, tremendous progress has been made in describing the diverse ways in which CK2 signaling promotes tumorigenesis, tumor maintenance, and progression. In this chapter, we address CK2’s role in cancer generally and then provide a detailed overview of CK2’s ability to regulate two oncogenic signaling pathways, NF-κB and JAK/STAT, in myriad contexts.

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Acknowledgments

This work was supported in part by NIH grant CA158534 (ENB), NS057563 (ENB), NS050665 (ENB), ABTA Basic Research Fellowship in Honor of Paul Fabbri (BCM), and the William E. Cash Jr. Memorial Fund in Neuro-Oncology Research (BCM).

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Authors and Affiliations

  1. Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Etty N. Benveniste Ph.D. & Braden C. McFarland

  2. PhD Program in Biological and Biomedical Sciences, Harvard University, Boston, MA, 02115, USA

    G. Kenneth Gray

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  1. Etty N. Benveniste Ph.D.
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  2. G. Kenneth Gray
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  3. Braden C. McFarland
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Correspondence to Etty N. Benveniste Ph.D. .

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  1. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, Minnesota, USA

    Khalil Ahmed

  2. Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark

    Olaf-Georg Issinger

  3. Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland

    Ryszard Szyszka

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Benveniste, E.N., Gray, G.K., McFarland, B.C. (2015). Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways. In: Ahmed, K., Issinger, OG., Szyszka, R. (eds) Protein Kinase CK2 Cellular Function in Normal and Disease States. Advances in Biochemistry in Health and Disease, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-14544-0_15

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