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Moving Forward the Discussion on Sudden Infant and Perinatal Unexplained Death

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Crib Death - Sudden Infant Death Syndrome (SIDS)

Abstract

Sudden infant death syndrome (SIDS) or crib death and sudden perinatal unexplained death (SPUD) represent facets of a multifactorial problem that has not yet found an unified approach on the clinical plane, and therefore only field of study that allows for the possibility of scientific progress is anatomic pathology The pathological findings and their relationship with SIDS and SPUD are discussed.

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References

  1. American Academy of Pediatrics (2012) Policy statement. Breastfeeding and the use of human milk. Pediatrics 129:e827–e841.

    Google Scholar 

  2. Anderson KR, Hill RW (1982) Occlusive lesions of cardiac conducting tissue arteries in sudden infant death syndrome. Pediatrics 69:50–52.

    PubMed  CAS  Google Scholar 

  3. Anderson RH (2000) Sudden and unexpected death in infancy and the conduction system of the heart. Cardiovasc Pathol 9:147–148.

    PubMed  CAS  Google Scholar 

  4. Anderson RH, Bouton J, Burrow CT, Smith A (1974) Sudden death in infancy: a study of cardiac specialized tissue. Br Med J 2:135–139.

    PubMed  CAS  PubMed Central  Google Scholar 

  5. Anderson WR, Edland JF, Schenk EA (1970) Conducting system changes in the sudden infant death syndrome. Am J Pathol 59:35a.

    Google Scholar 

  6. Arbustini E, Diegoli M, Grasso M, Fasani R, D’Armini A, Martinelli L, Goggi C, Campana C, Gavazzi A, Vigano M (1993) Expression of proliferating cell markers in normal and diseased human hearts. Am J Cardiol 72:608–614.

    PubMed  CAS  Google Scholar 

  7. Barton JR, Boheler KR, Brand NJ, Thomas PS (1995) Molecular biology of cardiac development and growth. Springer, Berlin/Heidelberg/New York.

    Google Scholar 

  8. Basso C, Corrado D, Rossi L, Thiene G (2001) Ventricular preexcitation in children and young adults: atrial myocarditis as a possible trigger of sudden death. Circulation 103:269–275.

    PubMed  CAS  Google Scholar 

  9. Bharati S, Lev M (1986) Congenital abnormalities in the conduction system in sudden death in young adults. J Am Coll Cardiol 8:1096–1104.

    PubMed  CAS  Google Scholar 

  10. Bharati S, Lev M (1994) Conduction system findings in sudden death in young adults with a history of bronchial asthma. J Am Coll Cardiol 23:741–746.

    PubMed  CAS  Google Scholar 

  11. Bharati S, Dreifus L, Bucheleres G, Molthan M, Covitz W, Isenberg HS, Lev M (1985) The conduction system in patients with a prolonged QT interval. J Am Coll Cardiol 6:1110–1119.

    PubMed  CAS  Google Scholar 

  12. Bharati S, Krongrad E, Lev M (1985) Study of the conduction system in a population of patients with sudden infant death syndrome. Pediatr Cardiol 6:29–40.

    PubMed  CAS  Google Scholar 

  13. Blanco CE, Hanson MA, Kumar P (1995) Breathing and sleep states in the fetus and at birth. In: Loughlin GM, Carrol JL, Marcus CL (eds) Sleep and breathing in children. A developmental approach. Marcel Dekker, Inc, New York, pp 161–179.

    Google Scholar 

  14. Bolande RP, Leistikow EA, Wartman F, Louis T (1996) The development of preatherosclerotic coronary artery lesions in perinatal piglets. Biol Neonate 69:109–118.

    PubMed  CAS  Google Scholar 

  15. Cacciatore J (2013) Psychological effects of stillbirth. Semin Fetal Neonatal Med 18:76–82.

    PubMed  Google Scholar 

  16. Centers for Disease Control and Prevention (CDC) (2014) Linked birth/infant death records, 2007–2010 results. http://wonder.cdc.gov/lbd-current.html. Accessed July 26, 2014.

  17. Chamberlin NL, Saper CB (1994) Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J Neurosci 414:6500–6510.

    Google Scholar 

  18. Cimaz R, Stramba-Badiale M, Brucato A, Catelli L, Panzeri P, Meroni PL (2000) QT interval prolongation in asymptomatic anti-SSA/Ro-positive infants without congenital heart block. Arthritis Rheum 43:1049–1053.

    PubMed  CAS  Google Scholar 

  19. Cohle SD, Lie JT (1991) Pathologic changes of the cardiac conduction tissue in sudden unexpected death. A review. Pathol Annu 26(Pt 2):33–57.

    PubMed  Google Scholar 

  20. Colombo B, Ottaviani G, Ramos SG, Matturri L (1998) Apoptosis in cardiac conduction system in sudden infant death syndrome (SIDS): preliminary results. In: Proceedings of the 5th SIDS International Conference, Rouen, p 157.

    Google Scholar 

  21. Crotti L, Tester DJ, White WM, Bartos DC, Insolia R, Besana A, Kunic JD, Will ML, Velasco EJ, Bair JJ, Ghidoni A, Cetin I, Van Dyke DL, Wick MJ, Brost B, Delisle BP, Facchinetti F, George AL, Schwartz PJ, Ackerman MJ (2013) Long QT syndrome-associated mutations in intrauterine fetal death. JAMA 309:1473–1482.

    PubMed  CAS  Google Scholar 

  22. Cuneo BF, Etheridge SP, Horigome H, Sallee D, Moon-Grady A, Weng HY, Ackerman MJ, Benson DW (2013) Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: risk stratification of perinatal long-QT syndrome. Circ Arrhythm Electrophysiol 6:946–951.

    PubMed  Google Scholar 

  23. Daliento L, Nava A, Fasoli G, Mazzucco A, Thiene G (1984) Dysplasia of the atrioventricular valves associated with conduction system anomalies. Br Heart J 51:243–251.

    PubMed  CAS  PubMed Central  Google Scholar 

  24. Davies MJ, Anderson RH, Becker AE (1983) The conduction system of the heart. Butterworth, London.

    Google Scholar 

  25. Dawes GS, Fox HE, Leduc BM, Liggins GC, Richards RT (1972) Respiratory movements and rapid eye movement sleep in the fetal lamb. J Physiol 220:119–143.

    PubMed  CAS  PubMed Central  Google Scholar 

  26. Doerr W (1957) Die morphologie des reizleitungssystemes ihre orthologie und pathologie. In: Spang K (ed) Rhythmusstörungen des herzens. Thieme, Stuttgart, pp 11–16.

    Google Scholar 

  27. Doerr W, Schiebler TH (1963) Pathologische anatomie des reizleitungssystems. In: Bargmann W, Doerr W (eds) Das Herz des Menschen. Thieme, Stuttgart.

    Google Scholar 

  28. Dony C, Gruss P (1987) Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal tissue. Nature 299:711–714.

    Google Scholar 

  29. Drobyshevsky A, Derrick M, Luo K, Zhang LQ, Wu YN, Takada SH, Yu L, Tan S (2012) Near-term fetal hypoxia-ischemia in rabbits: MRI can predict muscle tone abnormalities and deep brain injury. Stroke 43:2757–2763.

    PubMed  CAS  PubMed Central  Google Scholar 

  30. Eastman Q (2003) Genetics. Crib death exoneration could usher in new gene tests. Science 300:1858.

    PubMed  CAS  Google Scholar 

  31. Euler C (1986) Brainstem mechanisms for generation and control of breathing pattern. In: Cherniack NS, Waddicombe JG (eds) Handbook of physiology, Section 3. Respiration, vol 2: Control of breathing. American Psychological Society, Bethesda, pp 1–67.

    Google Scholar 

  32. Ferris JA (1972) Cot death – why not the heart? Med Sci Law 12:173–177.

    PubMed  CAS  Google Scholar 

  33. Ferris JA (1973) Hypoxic changes in conducting tissue of the heart in sudden death in infancy syndrome. Br Med J 2:23–25.

    PubMed  CAS  PubMed Central  Google Scholar 

  34. Ferris JA, Aherne WA (1971) Cartilage in relation to the conducting tissue of the heart in sudden death. Lancet 1:64–66.

    PubMed  CAS  Google Scholar 

  35. Filiano JJ, Kinney HC (1992) Arcuate nucleus hypoplasia in the sudden infant death syndrome. J Neuropathol Exp Neurol 51:394–403.

    PubMed  CAS  Google Scholar 

  36. Filiano JJ, Kinney HC (1994) A perspective on neuropathologic findings in victims of sudden infant death syndrome: the triple risk model. Biol Neonate 65:194–197.

    PubMed  CAS  Google Scholar 

  37. Giudicessi JR, Ackerman MJ (2013) Arrhythmia risk in long QT syndrome: beyond the disease-causative mutation. Circ Cardiovasc Genet 6:313–316.

    PubMed  Google Scholar 

  38. Gollob MH, Green MS, Tang AS-L, Gollob T, Karibe A, Hassa A, Ahmad F, Lozado R, Shah G, Fananapazir L, Bachinski L, Roberts R (2001) Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med 344:1823–1831.

    PubMed  CAS  Google Scholar 

  39. Guareschi M, Ottaviani G, Ramos SG, Matturri L (1998) Morte improvvisa del lattante (SIDS): un caso con vie accessorie e resorptive degeneration. Pathologica 90:294–297.

    PubMed  CAS  Google Scholar 

  40. Guntheroth WG, Spiers PS (1996) Are bedding and rebreathing suffocation a cause of SIDS? Pediatr Pulmonol 22:335–341.

    PubMed  CAS  Google Scholar 

  41. Guntheroth WG, Spiers PS (1999) Prolongation of the QT interval and the sudden infant death syndrome. Pediatrics 10:813–814.

    Google Scholar 

  42. Hervonen A, Vaalasti A, Partanen M, Kanerva L, Vaalasti T (1976) The paraganglia, a persisting endocrine system in man. Am J Anat 146:207–210.

    PubMed  CAS  Google Scholar 

  43. Hirano T, Simbulan D, Kumayawa T (1994) Effects of kainic acid in the parabrachial region for ongoing respiratory activity and reflexive respiratory suppression. Brain Res 665:54–62.

    PubMed  CAS  Google Scholar 

  44. Ho SY, Anderson RH (1988) Conduction tissue and SIDS. Ann N Y Acad Sci 533:176–190.

    PubMed  CAS  Google Scholar 

  45. Ho SY, Mortimer G, Anderson RH, Pomerance A, Keelings JW (1985) Conduction system defects in three perinatal patients with arrhythmia. Br Heart J 53:158–163.

    PubMed  CAS  PubMed Central  Google Scholar 

  46. Hunt CE, Hauck FR (2010) Sudden infant death syndrome: gene-environment interactions. In: Brugada R (ed) Clinical approach to sudden cardiac death syndromes. Springer, London, pp 7–21

    Google Scholar 

  47. Iams JD, Lynch CD (2011) Stillbirth and lessons for pregnancy care. JAMA 306:2506–2507.

    PubMed  CAS  Google Scholar 

  48. Ip S, Chung M, Raman G, Trikalinos TA, Lau J (2009) A summary of the agency for healthcare research and quality’s evidence report on breastfeeding in developed countries. Breastfeed Med 1(Suppl):S17–S30.

    Google Scholar 

  49. Iranpour R, Kelishadi R, Babaie S, Khosravi-Darani K, Farajian S (2013) Comparison of long chain polyunsaturated fatty acid content in human milk in preterm and term deliveries and its correlation with mothers’ diet. J Res Med Sci 18:1–5.

    PubMed  PubMed Central  Google Scholar 

  50. James TN (1961) Morphology of the human atrioventricular node, with remarks pertinent to its electrophysiology. Am Heart J 62:756–777.

    PubMed  CAS  Google Scholar 

  51. James TN (1968) Sudden death in babies: new observation in the heart. Am J Cardiol 22:479–506.

    PubMed  CAS  Google Scholar 

  52. James TN (1970) Cardiac conduction system: fetal and postnatal development. Am J Cardiol 25:213–226.

    PubMed  CAS  Google Scholar 

  53. James TN (1976) Sudden death of babies. Circulation 53:1–2.

    PubMed  CAS  Google Scholar 

  54. James TN (1983) Change and sudden death. J Am Coll Cardiol 1:164–183.

    PubMed  CAS  Google Scholar 

  55. James TN (1983) The Mikamo lecture. Structure and function of AV junction. Jpn Circ J 47:1–47.

    PubMed  CAS  Google Scholar 

  56. James TN (1985) Crib death. J Am Coll Cardiol 5:1185–1187.

    PubMed  CAS  Google Scholar 

  57. James TN (1985) Normal variations and pathologic changes in structure of the cardiac conduction system and their functional significance. J Am Coll Cardiol 5:71B–78B.

    PubMed  CAS  Google Scholar 

  58. James TN (1993) Congenital disorders of cardiac rhythm and conduction. J Cardiovasc Electrophysiol 4:702–718.

    PubMed  CAS  Google Scholar 

  59. James TN (1994) Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation 90:556–573.

    PubMed  CAS  Google Scholar 

  60. James TN (1996) Long reflections on the QT interval: the sixth annual Gordon K. Moe lecture. J Cardiovasc Electrophysiol 7:738–759.

    PubMed  CAS  Google Scholar 

  61. James TN (1997) Apoptosis in congenital heart disease. Coron Artery Dis 8:599–616.

    PubMed  CAS  Google Scholar 

  62. James TN (1998) Normal and abnormal consequences of apoptosis in the human heart. Annu Rev Physiol 60:309–325.

    PubMed  CAS  Google Scholar 

  63. James TN (1999) Apoptosis in cardiac disease. Am J Med 107:606–620.

    PubMed  CAS  Google Scholar 

  64. James TN (2002) Structure and function of the sinus node, AV node and His bundle of the human heart: part I – structure. Prog Cardiovasc Dis 45:235–267.

    PubMed  Google Scholar 

  65. James TN (2003) Structure and function of the sinus node, AV node and His bundle of the human heart: part II – function. Prog Cardiovasc Dis 45:327–360.

    PubMed  Google Scholar 

  66. James TN, Marshall TK (1976) De Subitaneis Mortibus XVIII. Persistent fetal dispersion of the atrioventricular node and His bundle within the central fibrous body. Circulation 6:1026–1034.

    Google Scholar 

  67. James TN, Froggatt P, Marshall TK (1967) Sudden death in young athletes. Ann Intern Med 67:1013–1021.

    PubMed  CAS  Google Scholar 

  68. James TN, Froggatt P, Atkinson WJ Jr, Lurie PR, McNamara DG, Miller WW, Schloss GT, Carroll JF, North RL (1978) De subitaneis mortibus XXX. Observations on the pathophysiology of the QT syndromes with special reference to the neuropathology of the heart. Circulation 57:1221–1231.

    PubMed  CAS  Google Scholar 

  69. James TN, Nichols MM, Sapire DW, Di Patre PL, Lopez SM (1996) Complete heart block and fatal right ventricular failure in an infant. Circulation 93:1588–1600.

    PubMed  CAS  Google Scholar 

  70. James TN, St. Martin E, Willis PW 3rd, Lohr TO (1996) Apoptosis as a possible cause of gradual development of complete heart block and fatal arrhythmias associated with absence of the AV node, sinus node and internodal pathways. Circulation 93:1424–1438.

    PubMed  CAS  Google Scholar 

  71. Jankus A (1976) The cardiac conduction system in sudden infant death syndrome: a report on three cases. Pathology 8:275–280.

    PubMed  CAS  Google Scholar 

  72. Jervell A, Lange-Nielsen F (1957) Congenital deaf-mutism, functional heart disease with prolongation of the QT interval and sudden death. Am Heart J 54:59–68.

    PubMed  CAS  Google Scholar 

  73. Kajstura J, Mansukhani M, Cheng W, Reiss K, Krajewski S, Reed JC, Quaini F, Sonnenblick EH, Anversa P (1995) Programmed cell death and expression of the protooncogene bcl-2 in myocytes during postnatal maturation of the heart. Exp Cell Res 219:110–121.

    PubMed  CAS  Google Scholar 

  74. Kent AFS (1893) Researches on the structure and function of the mammalian heart. J Physiol 14:233–254.

    Google Scholar 

  75. Kinney HC, Filiano JJ, Harper RM (1992) The neuropathology of the sudden infant death syndrome. A review. J Neuropathol Exp Neurol 51:115–126.

    PubMed  CAS  Google Scholar 

  76. Kinney HC, O’Donnel TJ, Kriger P, White WF (1993) Early developmental changes in H3-nicotine binding in the human brainstem. Neuroscience 55:1127–1138.

    PubMed  CAS  Google Scholar 

  77. Kozakewich HPW, McManus BM, Vawter G (1982) The sinus node in sudden infant death syndrome. Circulation 65:1242–1246.

    PubMed  CAS  Google Scholar 

  78. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Gu Y, Ikeda Y, Chu PH, Ross J Jr, Giles WR, Chien KR (2001) A defect in the Kv channel-interacting protein 2 (KchIP2) gene leads to a complete loss of Ito and confers susceptibility to ventricular tachycardia. Cell 107:801–812.

    PubMed  CAS  Google Scholar 

  79. Lavezzi AM, Ottaviani G, Matturri L (2003) Identification of neurons responding to hypoxia in sudden infant death syndrome (SIDS). Pathol Int 53:769–774.

    PubMed  Google Scholar 

  80. Lavezzi AM, Ottaviani G, Ballabio G, Rossi L, Matturri L (2004) Preliminary study on the cytoarchitecture of the human parabrachial/Kölliker-Fuse complex, with reference to sudden infant death syndrome and sudden intrauterine unexplained death. Pediatr Dev Pathol 7:171–179.

    PubMed  Google Scholar 

  81. Lavezzi AM, Ottaviani G, Mauri M, Matturri L (2004) Hypoplasia of the arcuate nucleus and maternal smoking during pregnancy, in perinatal and infant sudden unexpected death. Neuropathology 24:284–289.

    PubMed  Google Scholar 

  82. Lavezzi AM, Ottaviani G, Matturri L (2004) Involvement of somatostatin in breathing control before and after birth, and in perinatal and infant sudden unexplained death. Folia Neuropathol 42:59–65.

    PubMed  CAS  Google Scholar 

  83. Lavezzi AM, Ottaviani G, Matturri L (2004) Role of somatostatin and apoptosis in breathing control in sudden perinatal and infant unexplained death. Clin Neuropathol 23:304–310.

    PubMed  CAS  Google Scholar 

  84. Lavezzi AM, Ottaviani G, Rossi L, Matturri L (2004) Cytoarchitectural organization of the Parabrachial/Kölliker-Fuse complex in man. Brain Dev 26:316–320.

    PubMed  Google Scholar 

  85. Lavezzi AM, Ottaviani G, Rossi L, Matturri L (2004) Hypoplasia of the parabrachial/Kölliker-Fuse complex in perinatal death. Biol Neonate 86:92–97.

    PubMed  Google Scholar 

  86. Lavezzi AM, Ottaviani G, Matturri L (2005) Adverse effects of prenatal tobacco smoke exposure on biological parameters of the developing brainstem. Neurobiol Dis 20:601–607.

    PubMed  CAS  Google Scholar 

  87. Lavezzi AM, Ottaviani G, Matturri L (2005) Biology of the smooth muscle cells in human atherosclerosis. APMIS 113:112–121.

    PubMed  Google Scholar 

  88. Lavezzi AM, Ottaviani G, Mauri M, Terni L, Matturri L (2005) Involvement of the EN-2 gene in normal and abnormal development of the human arcuate nucleus. Int J Exp Pathol 86:25–31.

    PubMed  CAS  PubMed Central  Google Scholar 

  89. Lavezzi AM, Ottaviani G, Mauri M, Matturri L (2006) Alterations of biological features of the cerebellum in sudden perinatal and infant death. Curr Mol Med 6:429–435.

    PubMed  CAS  Google Scholar 

  90. Lavezzi AM, Ottaviani G, Terni L, Matturri L (2006) Histological and biological developmental characterization of the human cerebellar cortex. Int J Dev Neurosci 24:365–371.

    PubMed  Google Scholar 

  91. Lavezzi AM, Casale V, Oneda R, Weese-Mayer DE, Matturri L (2009) Sudden infant death syndrome and sudden intrauterine unexplained death: correlation between hypoplasia of raphé nuclei and serotonin transporter gene promoter polymorphism. Pediatr Res 66:22–27.

    PubMed  CAS  Google Scholar 

  92. Lavezzi AM, Mehboob R, Matturri L (2011) Developmental alterations of the spinal trigeminal nucleus disclosed by substance P immunohistochemistry in fetal and infant sudden unexplained deaths. Neuropathology 31:405–413.

    PubMed  Google Scholar 

  93. Liebrechts-Akkerman G, Lao O, Liu F, van Sleuwen BE, Engelberts AC, L’hoir MP, Tiemeier HW, Kayser M (2011) Postnatal parental smoking: an important risk factor for SIDS. Eur J Pediatr 170:1281–1291.

    PubMed  PubMed Central  Google Scholar 

  94. Lie JT, Rosenberg HS, Erickson EE (1976) Histopathology of the conduction system in the sudden infant death syndrome. Circulation 53:3–8.

    PubMed  CAS  Google Scholar 

  95. Lown B, Ganong WF, Levine SA (1952) The syndrome of short P-R interval, normal QRS complex and paroxysmal rapid heart action. Circulation 5:693–706.

    PubMed  CAS  Google Scholar 

  96. MacDorman MF, Kirmeyer SE, Wilson EC (2012) Fetal and perinatal mortality, United States, 2006. Natl Vital Stat Rep 60:1–23. www.cdc.gov/nchs/data/nvsr/nvsr60/nvsr60_08.pdf. Accessed July 26, 2014.

  97. Mahaim I, Benatt A (1938) Nouvelles recherches sur les connexions superiors de la branche gauche du faisceau de His-Tawara avec cloison interventriculaire. Cardiologia 1:61–120.

    Google Scholar 

  98. Marino TA, Kane BM (1985) Cardiac atrioventricular junctional tissues in hearts from infants who died suddenly. J Am Coll Cardiol 5:1178–1184.

    PubMed  CAS  Google Scholar 

  99. Marino TA, Haldar S, Williamson EC, Beaverson K, Walter RA, Marino DR, Beatty C, Lipson KE (1991) Proliferating cell nuclear antigen in developing and adult rat cardiac muscle cells. Circ Res 69:1353–1360.

    PubMed  CAS  Google Scholar 

  100. Maron BJ, Clark CE, Goldstein RE, Epstein SE (1976) Potential role of QT interval prolongation in sudden infant death syndrome. Circulation 54:423–430.

    PubMed  CAS  Google Scholar 

  101. Massing GK, James TN (1976) Anatomical configuration of the His bundle and bundle branches in the human heart. Circulation 53:609–621.

    PubMed  CAS  Google Scholar 

  102. Matturri L, Nappo A, Varesi C, Martini I, Rossi L (1997) Dualismo del nodo atrioventricolare per la presenza del nodo del seno coronarico di Zahn in un caso di morte improvvisa del lattante (SIDS). Riv Ital Pediatr 23:130–133.

    Google Scholar 

  103. Matturri L, Ottaviani G, Biondo B, Ramos SG, Rossi L (1998) Discrete T-lymphocytic leptomeningitis of the ventral medullary surface in a case of sudden unexpected infant death. Adv Clin Path 2:313–316.

    PubMed  Google Scholar 

  104. Matturri L, Ottaviani G, Rossi L (1999) Sudden and unexpected infant death due to an hemangioendothelioma located in the medulla oblongata. Adv Clin Path 3:29–33.

    PubMed  CAS  Google Scholar 

  105. Matturri L, Ottaviani G, Ramos SG, Rossi L (2000) Sudden infant death syndrome (SIDS). A study of cardiac conduction system. Cardiovasc Pathol 9:137–145.

    PubMed  CAS  Google Scholar 

  106. Matturri L, Ottaviani G, Lavezzi AM, Turconi P, Cazzullo A, Rossi L (2001) Expression of apoptosis and proliferating cell nuclear antigen (PCNA) in the cardiac conduction system of crib death (SIDS). Adv Clin Path 5:79–86.

    PubMed  CAS  Google Scholar 

  107. Matturri L, Biondo B, Suàrez-Mier MP, Rossi L (2002) Brain stem lesions in the sudden infant death syndrome: variability in the hypoplasia of the arcuate nucleus. Acta Neuropathol (Berl) 194:12–20.

    Google Scholar 

  108. Matturri L, Lavezzi AM, Ottaviani G, Rossi L (2002) Anatomia patologica della sindrome della morte improvvisa del lattante (SIDS) e della morte inaspettata del feto. In: Proceedings of the National Symposium “Sudden Infant Death Syndrome (SIDS) and Sudden Unexplained Intrauterine Death”, Milan, pp 13–23.

    Google Scholar 

  109. Matturri L, Minoli I, Lavezzi AM, Cappellini A, Ramos S, Rossi L (2002) Hypoplasia of medullary arcuate nucleus in unexpected late fetal death (stillborn infants): a pathological study. Pediatrics 109:E43.

    PubMed  Google Scholar 

  110. Matturri L, Ottaviani G, Ballabio G, Lavezzi AM (2002) Medullary arcuate nucleus’ cellular differentiation in SIDS and unexpected late fetal stillbirth cases. In: Proceedings of the 7th SIDS International Conference, Florence, p 135.

    Google Scholar 

  111. Matturri L, Ottaviani G, Rossi L (2002) Should overdone external cardiac massage in infants dying of SIDS be discouraged? In: Proceedings of the 7th International Conference on SIDS, Florence, p 136.

    Google Scholar 

  112. Matturri L, Lavezzi AM, Minoli I, Ottaviani G, Cappellini A, Rubino B, Rossi L (2003) Association between pulmonary hypoplasia and hypoplasia of arcuate nucleus in stillbirth. J Perinatol 23:328–332.

    PubMed  Google Scholar 

  113. Matturri L, Lavezzi AM, Ottaviani G, Rossi L (2003) Intimal preatherosclerotic thickening of the coronary arteries in human fetuses of smoker mothers. J Thromb Haemost 1:2234–2238.

    PubMed  CAS  Google Scholar 

  114. Matturri L, Ottaviani G, Rossi L (2003) External cardiac massage in infants. Intensive Care Med 29:1199–1200.

    PubMed  Google Scholar 

  115. Matturri L, Ottaviani G, Alfonsi G, Crippa M, Rossi L, Lavezzi AM (2004) Study of the brainstem, particularly the arcuate nucleus, in sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD). Am J Forensic Med Pathol 25:44–48.

    PubMed  Google Scholar 

  116. Matturri L, Ottaviani G, Corti G, Lavezzi AM (2004) Pathogenesis of early atherosclerotic lesions in infants. Pathol Res Pract 200:403–410.

    PubMed  Google Scholar 

  117. Matturri L, Ottaviani G, Lavezzi AM, Rossi L (2004) Early atherosclerotic lesions of the cardiac conduction system arteries in infants. Cardiovasc Pathol 13:276–281.

    PubMed  Google Scholar 

  118. Matturri L, Ottaviani G, Lavezzi AM, Grana DR, Milei J (2005) Natural history of perinatal and infant coronary atherosclerosis due to maternal cigarette smoking. In: Proceedings of the “4th World Congress of Pediatric Cardiology and Cardiac Surgery” Buenos Aires, p 31.

    Google Scholar 

  119. Matturri L, Ottaviani G, Lavezzi AM, Grana DR, Milei J (2005) Perinatal and infant early atherosclerotic coronary lesions related to maternal smoking. In: Proceedings of the “4th World Congress of Pediatric Cardiology and Cardiac Surgery”, Buenos Aires, p 48.

    Google Scholar 

  120. Matturri L, Ottaviani G, Benedetti G, Agosta E, Lavezzi AM (2005) Unexpected perinatal death and sudden infant death syndrome (SIDS): anatomopathologic and legal aspects. Am J Forensic Med Pathol 26:155–160.

    PubMed  Google Scholar 

  121. Matturri L, Ottaviani G, Lavezzi AM (2005) Early atherosclerotic lesions in infancy: role of parental cigarette smoking. Virchows Arch 447:74–80.

    PubMed  Google Scholar 

  122. Matturri L, Ottaviani G, Lavezzi AM (2005) Sudden infant death triggered by dive reflex. J Clin Pathol 58:77–80.

    PubMed  CAS  PubMed Central  Google Scholar 

  123. Matturri L, Ottaviani G, Lavezzi AM (2005) Perinatal and infant atherosclerotic coronary lesions related to maternal smoking. In: Proceedings of the “6th International Congress on Coronary Artery Disease: from Prevention to Intervention”, Istanbul, p 66.

    Google Scholar 

  124. Matturri L, Ottaviani G, Lavezzi AM (2005) Techniques and criteria in pathologic and forensic-medical diagnostics in sudden unexpected infant and perinatal death. Am J Clin Pathol 124:259–268.

    PubMed  Google Scholar 

  125. Matturri L, Ottaviani G, Lavezzi AM (2005) Unexpected sudden death related to medullary brain lesions. Acta Neuropathol (Berl) 109:554–555.

    Google Scholar 

  126. Matturri L, Ottaviani G, Lavezzi AM, Ramos SG (2005) Peripheral chemoreceptors and sudden infant death syndrome: a wide open problem. Curr Cardiol Rev 1:65–70.

    Google Scholar 

  127. Matturri L, Ottaviani G, Lavezzi AM (2006) Maternal smoking and sudden infant death syndrome: epidemiological study related to pathology. Virchows Arch 449:697–706.

    PubMed  Google Scholar 

  128. Matturri L, Ottaviani G, Minoli I, Mauri M, Lavezzi AM (2007) Neonatal pulmonary hypoplasia frequently associated with brainstem hypodevelopment. 8th World Congress of Perinatal Medicine. Florence, Italy. J Perinat Med 35(Suppl):209.

    Google Scholar 

  129. Matturri L, Ottaviani G, Mingrone R, Lavezzi AM, Fulcheri E (2007) Sudden intrauterine unexplained death (SIUD) «gray zone» or borderline. 8th World Congress of Perinatal Medicine. Florence, Italy. J Perinat Med 35(Suppl):210.

    Google Scholar 

  130. Matturri L, Ottaviani G, Nonnis Marzano F, Lavezzi AM (2006) Stillbirth versus SIDS. Pathology of the autonomic nervous system and DNA polymorphisms in SIUD and SIDS. In: Proceedings of the 9th SIDS International Conference, Yokohama, pp 105–106.

    Google Scholar 

  131. Matturri L, Ottaviani G, Lavezzi AM (2008) Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS) – a technical protocol. Virchows Arch 452:19–25.

    PubMed  Google Scholar 

  132. Matturri L, Lavezzi AM (2011) Unexplained stillbirth versus SIDS: common congenital diseases of the autonomic nervous system–pathology and nosology. Early Hum Dev 87:209–215.

    PubMed  Google Scholar 

  133. Milei J, Ottaviani G, Lavezzi AM, Grana DR, Stella I, Matturri L (2008) Perinatal and infant early atherosclerotic coronary lesions. Can J Cardiol 24:137–141.

    PubMed  PubMed Central  Google Scholar 

  134. Moon HD (1957) Coronary arteries in fetuses, infants and juveniles. Circulation 16:263–267.

    PubMed  CAS  Google Scholar 

  135. Morpurgo CV, Lavezzi AM, Ottaviani G, Rossi L (2004) Bulbo-spinal pathology and sudden respiratory infant death syndrome. Eur J Anaesthesiol 21:589–593.

    PubMed  CAS  Google Scholar 

  136. Nachmanoff DB, Panigrahy A, Filiano JJ, Sieeper LA, Valdes-Dapena M, Krous HF, White WF, Kinney HC (1998) Brainstem H3-nicotine receptor binding in the sudden infant death syndrome. J Neuropathol Exp Neurol 57:1018–1025.

    PubMed  CAS  Google Scholar 

  137. Olszewski J, Baxter D (1982) Cytoarchitecture of the human brain stem. Karger, Basel.

    Google Scholar 

  138. Ottaviani G (2006) Histological observation of the cardiac conduction system in the diagnostics of sudden infant death syndrome (SIDS). “SIDS e ALTE Aggiornamento 2005. Primo Corso Teorico Pratico di Anatomia-Patologica in casi di Sospetta SIDS e di morte inaspettata fetale”, Parma, Italy. Acta Biomed Ateneo Parmense 77:52.

    Google Scholar 

  139. Ottaviani G, Ramos SG, Matturri L (1997) Defective “resorptive degeneration” of the heart’s conduction system and sudden infant death syndrome. Ann Españ Pediatr 92(Suppl):53.

    Google Scholar 

  140. Ottaviani G, Goisis M, Ramos SG, Matturri L (1998) Dispersione del tessuto giunzionale e sue conseguenze in un caso di morte improvvisa del lattante. Cardiologia 43:737–739.

    PubMed  CAS  Google Scholar 

  141. Ottaviani G, Matturri L, Ramos SG, Rossi L (1998) Resorptive degeneration of the heart’s conduction system and sudden infant death syndrome: preliminary results. In: Proceedings of the 5th SIDS International Conference, Rouen, p 156.

    Google Scholar 

  142. Ottaviani G, Rossi L, Bondurri A, Ramos SG, Matturri L (1998) Morte improvvisa del lattante: un caso di sdoppiamento del nodo atrio-ventricolare. Riv Ital Pediatr 24:1165–1167.

    Google Scholar 

  143. Ottaviani G, Lavezzi AM, Rossi L, Matturri L (1999) Proliferating cell nuclear antigen (PCNA) and apoptosis in hyperacute and acute myocardial infarction. Eur J Histochem 43:7–14.

    PubMed  CAS  Google Scholar 

  144. Ottaviani G, James TN, Rossi L, Matturri L (2002) Significance of Mahaim fibers in crib death. In: Proceedings of the 7th SIDS International Conference, Florence, p 136.

    Google Scholar 

  145. Ottaviani G, Matturri L, Lavezzi AM, Rossi L, James TN (2002) Postnatal apoptosis of the cardiac conduction system in crib death: preliminary results. In: Proceedings of the 7th SIDS International Conference, Florence, p 132.

    Google Scholar 

  146. Ottaviani G, Matturri L, Rossi L, James TN (2002) Crib death: further support for the concept of fatal cardiac electrical instability as the final common pathway. In: Proceedings of the 7th SIDS International Conference, Florence, p 66.

    Google Scholar 

  147. Ottaviani G, Matturri L, Rossi L, James TN (2003) Crib death: further support for the concept of fatal cardiac electrical instability as the final common pathway. Int J Cardiol 92:17–26.

    PubMed  Google Scholar 

  148. Ottaviani G, Lavezzi AM, Rossi L, Matturri L (2004) Sudden unexpected death of a term fetus in a anticardiolipin positive mother. Am J Perinatol 21:31–35.

    Google Scholar 

  149. Ottaviani G, Matturri L, Rossi L, Lavezzi AM, James TN (2004) Multifocal cardiac Purkinje cell tumor in infancy. Europace 6:138–141.

    PubMed  Google Scholar 

  150. Ottaviani G, Matturri L, Bruni B, Lavezzi AM (2005) Sudden infant death syndrome “gray zone” disclosed only by a study of the brain stem on serial sections. J Perinat Med 33:165–169.

    PubMed  Google Scholar 

  151. Ottaviani G, Rossi L, Matturri L (2005) Myocardial injury attributable to external cardiac massage in infants. Cardiology 1:25–29.

    Google Scholar 

  152. Ottaviani G, Matturri L, Mingrone R, Lavezzi AM (2006) Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death. J Clin Pathol 59:497–500.

    PubMed  CAS  PubMed Central  Google Scholar 

  153. Ottaviani G (2006) A case of respiratory unexpected death. “SIDS e ALTE Aggiornamento 2005. Primo Corso Teorico Pratico di Anatomia-Patologica in casi di sospetta SIDS e di morte inaspettata fetale”. Parma, Italy. Acta Biomed Ateneo Parmense 77:45.

    Google Scholar 

  154. Ottaviani G (2006) Morte improvvisa inaspettata perinatale e del lattante (SIDS): studio istopatologico del sistema di conduzione cardiaco. In: Proceedings of the Conference “Morte improvvisa del lattante (SIDS) e morte inaspettata del feto: La rilevanza medico-sociale e formativa della ricerca scientifica: la legge 31 del 2006”. Corso di .alta formazione continua: “Tecniche e criteri anatomo-patologici e medico-legali nella diagnostica della morte inaspettata del feto versus SIDS”, Milan, pp 73–78.

    Google Scholar 

  155. Ottaviani G (2006) Studio istopatologico del sistema di conduzione cardiaco nella morte improvvisa del lattante e perinatale. In: Proceedings of the Convegno “Morte improvvisa del lattante e morte inaspettata del feto. La rilevanza giuridica e medico-sociale della ricerca scientifica: la legge n. 31 del 2006”, Gargnano, pp 63–74.

    Google Scholar 

  156. Ottaviani G, Matturri L (2007) Cardiovascular pathology of sudden perinatal unexpected death (SPUD) and sudden infant death syndrome (SIDS). 8th World Congress of Perinatal Medicine, Florence, Italy. J Perinat Med 35(Suppl):229–230.

    Google Scholar 

  157. Ottaviani G, Matturri L (2008) Histopathology of the cardiac conduction system in sudden intrauterine unexplained death. Cardiovasc Pathol 17:146–155.

    PubMed  Google Scholar 

  158. Ottaviani G, Bergui G (2009) Sudden unexpected death in infancy (SUDI): A new anatomo-clinical approach. Europace 11:395.

    PubMed  Google Scholar 

  159. Ottaviani G, Mingrone R, Lavezzi AM, Matturri L (2009) Infant and perinatal pulmonary hypoplasia frequently associated with brainstem hypodevelopment. Virchows Arch 454:451–456.

    PubMed  Google Scholar 

  160. Ottaviani G (2010) In utero exposure to smoking and peripheral chemoreceptor function. Pediatrics [E-letter]. http://pediatrics.aappublications.org/content/125/3/e592/reply. Accessed July 26, 2014.

  161. Ottaviani G (2011) Sudden deaths in term infants within 24 hours of birth. Pediatrics. http://pediatrics.aappublications.org/content/127/4/e869/reply. Accessed July 26, 2014.

  162. Ottaviani G (2011) Sudden infant and perinatal unexplained death: are we moving forward yet? Cardiovasc Pathol 10:302–306.

    Google Scholar 

  163. Pacharn P, Kline-Fath B, Calvo-Garcia M, Linam LE, Rubio EI, Salisbury S, Brody AS (2013) Congenital lung lesions: prenatal MRI and postnatal findings. Pediatr Radiol 43:1136–1143

    PubMed  Google Scholar 

  164. Priori SG, Bloise R, Crotti L (2001) The long QT syndrome. Europace 3:16–27.

    PubMed  CAS  Google Scholar 

  165. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C, Document Reviewers, Ackerman M, Belhassen B, Estes NA 3rd, Fatkin D, Kalman J, Kaufman E, Kirchhof P, Schulze-Bahr E, Wolpert C, Vohra J, Refaat M, Etheridge SP, Campbell RM, Martin ET, Quek SC (2013) Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace 15:1389–1406.

    PubMed  Google Scholar 

  166. Ramos SG, Matturri L, Biondo B, Ottaviani G, Rossi L (1998) Hyperplasia of the aorticopulmonary paraganglia: a new insight into the pathogenesis of sudden infant death syndrome? Cardiologia 43:953–958.

    PubMed  CAS  Google Scholar 

  167. Ramos SG, Matturri L, Ottaviani G, Rossi L (1998) Maternal smoking and aorticopulmonary paraganglia in sudden infant death syndrome. In: Proceedings of the 5th SIDS International Conference, Rouen, p 169.

    Google Scholar 

  168. Ramos SG, Matturri L, Ottaviani G, Rossi L, Rossi MA (1999) Lesions of aorticopulmonary paraganglia related to sudden death: histopathologic considerations. J Heart Dis 1:141.

    Google Scholar 

  169. Ramos SG, Ottaviani G, Biondo B, Rossi L, Matturri L (1999) Hyperplasia of the aorticopulmonary paraganglia in infants dying of SIDS: further supports for the cardio-respiratory hypothesis. In: Proceedings of the International Symposium on SIDS and Lombardy Region project for the reduction of the risk for sudden infant death and unexplained intrauterine death, Milan, pp 117–128.

    Google Scholar 

  170. Rodan GA, Bourret LA, Norton LA (1978) DNA synthesis in cartilage cells is stimulated by oscillating electric fields. Science 199:690–692.

    PubMed  CAS  Google Scholar 

  171. Robertson JH (1960) The significance of intimal thickening in the arteries of the newborn. Arch Dis Child 35:588–590.

    PubMed  CAS  PubMed Central  Google Scholar 

  172. Romano C, Gemme G, Pongiglione R (1963) Rare cardiac arrythmias of the pediatric age. II. Syncopal attacks due to paroxysmal ventricular fibrillation. Presentation of the 1st case in Italian literature. Clin Pediatr (Bologna) 45:656–683.

    CAS  Google Scholar 

  173. Rossenbacker T, Priori SG (2007) Clinical diagnosis of long QT syndrome: back to the caliper. Eur Heart J 28:527–528.

    PubMed  Google Scholar 

  174. Rossi L (1969) Histopathologic features of cardiac arrhythmias. Casa Editrice Ambrosiana, Milan.

    Google Scholar 

  175. Rossi L (1975) A histological survey of pre-excitation syndrome and related arrhythmias. G Ital Cardiol 5:816–828.

    PubMed  CAS  Google Scholar 

  176. Rossi L (1978) Intramural ramification of the left bundle branch. Am Heart J 96:271–272.

    PubMed  CAS  Google Scholar 

  177. Rossi L (1983) The pathologic basis of cardiac arrhythmias. Cardiol Clin 1:13–17.

    PubMed  CAS  Google Scholar 

  178. Rossi L (1998) Histopathology of the cardiac conduction system in the problem of arrhythmogenic SIDS. In: Proceedings of the 18th International Symposium on Neonatal Intensive Care, Milan, p 75.

    Google Scholar 

  179. Rossi L, Matturri L (1988) His bundle haematoma and external cardiac massage: histopathological findings. Br Heart J 59:586–587.

    PubMed  CAS  PubMed Central  Google Scholar 

  180. Rossi L, Matturri L (1990) Clinicopathological approach to cardiac arrhythmias. A color atlas. Centro Scientifico Torinese, Turin.

    Google Scholar 

  181. Rossi L, Matturri L (1991) Anatomohistological features of sudden infant death. New Trends Arrhyt 6:135–142.

    Google Scholar 

  182. Rossi L, Matturri L (1995) Anatomo-histological features of the heart’s conduction system and innervation in SIDS. In: Rognum TO (ed) Sudden infant death syndrome: new trends in the nineties. Scandinavian University Press, Oslo, pp 207–212.

    Google Scholar 

  183. Rossi L, Matturri L (1995) Cardiac conduction and nervous system in health disease and sudden death: an anatomoclinical overview. Osp Maggiore 89:239–257.

    Google Scholar 

  184. Rossi L, Matturri L (1998) Neuronal degeneration localized in the thoracic spinal cord sympathetic center in a case with prolonged QT interval. G Ital Cardiol 28(Suppl):535–537.

    Google Scholar 

  185. Rossi L, Thiene G (1983) Arrhythmologic pathology of sudden cardiac death. Casa Editrice Ambrosiana, Milan.

    Google Scholar 

  186. Rossi L, Knippel M, Taccardi B (1975) Histological findings. His bundle recordings and bodysurface potential mappings in a case of Wolff-Parkinson-White syndrome. An anatomoclinical comparison. Cardiology 60:265–279.

    PubMed  CAS  Google Scholar 

  187. Rossi L, Thiene G, Knippel M (1978) A case of surgically corrected Wolff-Parkinson-White syndrome: clinical and histological data. Br Heart J 40:581–585.

    PubMed  CAS  PubMed Central  Google Scholar 

  188. Rossi L, Piffer R, Turolla E, Frigerio B, Coumel P, James TN (1985) Multifocal purkinje-like tumor of the heart. Occurrence with other anatomic abnormalities in the atrioventricular junction of an infant with junctional tachycardia, Lown-Ganong-Levine syndrome, and sudden death. Chest 87:340–345.

    PubMed  CAS  Google Scholar 

  189. Rossi L, Matturri L, Lotto A (1988) Cardiac conduction blocks and pacemaking. An anatomoclinical color atlas. Clas International, Brescia.

    Google Scholar 

  190. Rossi L, Pozzato R, Matturri L (1991) L’anatomia patologica della morte cardiaca oggi. Riv Ital Med Leg 13:93–110.

    Google Scholar 

  191. Rossi L, Matturri L, Ottaviani G (2002) Arrhythmogenic sudden death in the modern setting SIDS. An overview. In: Proceedings of the 7th International Conference on SIDS, Florence, p 153.

    Google Scholar 

  192. Rossi L, Matturri L, Ottaviani G (2002) Sudden unexpected death of a term fetus with maternal infant anti-cardiolipin antibodies. A case report. In: Proceedings of the 7th International Conference on SIDS, Florence, p 137.

    Google Scholar 

  193. Rumyantsev PP (1977) Interrelations of the proliferation and differentiation processes during cardiac myogenesis and regeneration. Int Rev Cytol 51:187–273.

    CAS  Google Scholar 

  194. Schaller B, Cornelius JF, Sandu N, Ottaviani G, Perez-Pinzon MA (2009) Oxygen-conserving reflexes of the brain: the current molecular knowledge. J Cell Mol Med 13:644–647.

    PubMed  CAS  Google Scholar 

  195. Schwartz PJ (1976) Cardiac sympathetic innervation and the sudden infant death syndrome. A possible pathogenetic link. Am J Med 60:167–172.

    PubMed  CAS  Google Scholar 

  196. Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti RR, Grancini F, Marini ED, Perticone F, Rositi D, Salice P (1998) Prolongation of the QT interval and the sudden infant death syndrome. N Engl J Med 338:1709–1714.

    PubMed  CAS  Google Scholar 

  197. Schwartz PJ, Priori SG, Dumaine R, Napolitano C, Antzelevitch C, Stramba-Badiale M, Richard TA, Berti MR, Bloise R (2000) A molecular link between the sudden infant death syndrome and the long-QT syndrome. N Engl J Med 343:262–267.

    PubMed  CAS  Google Scholar 

  198. Southall DP, Arrowsmith WA, Stebbins V, Alexander JR (1986) QT interval measurements before sudden infant death syndrome. Arch Dis Child 61:327–333.

    PubMed  CAS  PubMed Central  Google Scholar 

  199. Stéphan-Blanchard E, Chardon K, Léké A, Delanaud S, Djeddi D, Libert JP, Bach V, Telliez F (2010) In utero exposure to smoking and peripheral chemoreceptor function in preterm neonates. Pediatrics 125:e592–e599.

    PubMed  Google Scholar 

  200. Suàrez-Mier MP, Aguilera B (1998) Histopathology of the conduction system in sudden infant death. Forensic Sci Int 93:143–154.

    Google Scholar 

  201. Suàrez-Mier MP, Gamallo C (1998) Atrioventricular node fetal dispersion and His fragmentation of the cardiac conduction system in sudden cardiac death. J Am Coll Cardiol 32:1885–1890.

    PubMed  Google Scholar 

  202. Tester DJ, Ackerman MJ (2009) Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children. Annu Rev Med 60:69–84.

    PubMed  CAS  Google Scholar 

  203. Thiene G (1988) Problems in the interpretation of cardiac pathology in reference to SIDS. Ann N Y Acad Sci 533:191–199.

    PubMed  CAS  Google Scholar 

  204. Turner CJ, Wren C (2013) The epidemiology of arrhythmia in infants: a population-based study. J Paediatr Child Health 49:278–281.

    PubMed  Google Scholar 

  205. Valdès-Dapena M (1985) Are some crib deaths sudden cardiac deaths? J Am Coll Cardiol 5(6 Suppl):113B–117B.

    PubMed  Google Scholar 

  206. Valdés-Dapena M, Gilbert-Barness E (2002) Cardiovascular causes for sudden infant death. Pediatr Pathol Mol Med 21:195–211.

    PubMed  Google Scholar 

  207. Valdés-Dapena MA, Greene M, Basavanand N, Catherman R, Truex RC (1973) The myocardial conduction system in sudden death in infancy. N Engl J Med 289:1179–1180.

    PubMed  Google Scholar 

  208. Van Norstrand DW, Ackerman MJ (2010) Genomic risk factors in sudden infant death syndrome. Genome Med 2:86.

    PubMed  PubMed Central  Google Scholar 

  209. Viskin S, Fish R, Roth A, Schwartz PJ, Belhassen B (2000) QT or not QT? N Engl J Med 343:352–356.

    PubMed  CAS  Google Scholar 

  210. Waldo AL, James TN (1973) A retrospective look at A-V nodal rhythms (A Zahn). Circulation 47:222–224.

    PubMed  CAS  Google Scholar 

  211. Ward OC (1964) A new familial cardiac syndrome in children. J Ir Med Assoc 54:103–106.

    PubMed  CAS  Google Scholar 

  212. Weinberg SB, Purdy BA (1970) Postmortem leukocyte culture studies in sudden infant death. Nature 226:1264–1265.

    PubMed  CAS  Google Scholar 

  213. Willinger M, Hoffman HJ, Hartford RB (1994) Infant sleep position and risk for sudden infant death syndrome: report of meeting held January 13 and 14, 1994, National Institutes of Health, Bethesda, MD. Pediatrics 93:814–819.

    PubMed  CAS  Google Scholar 

  214. Wolff GS, Han J, Curran G (1978) Wolff-Parkinson-White syndrome in the neonate. Am J Cardiol 41:559–563.

    PubMed  CAS  Google Scholar 

  215. Wolff L, Parkinson J, White PD (1930) Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. Am Heart J 5:685–704.

    Google Scholar 

  216. Wren C (1998) Mechanism of fetal tachycardia. Heart 79:536–539.

    PubMed  CAS  PubMed Central  Google Scholar 

  217. Wren C, Vogel M, Lord S, Abrams D, Bourke J, Rees P, Rosenthal E (2012) Accuracy of algorithms to predict accessory pathway location in children with Wolff-Parkinson-White syndrome. Heart 98:202–206.

    PubMed  Google Scholar 

  218. Yang Z, Lantz PE, Ibdah JA (2007) Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death. Pediatr Int 49:883–887.

    PubMed  CAS  Google Scholar 

  219. Zahn A (1912) Experimentelle untersuchungen über die reizbildung im atrioventrikularnoten und sinus coronarius. Zentralbl Physiol 26:495.

    Google Scholar 

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  1. Università degli Studi di Milano, Milano, Italy

    Giulia Ottaviani MD, PhD

  2. The University of Texas Health Science Center at Houston, Houston, TX, USA

    Giulia Ottaviani MD, PhD

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Ottaviani, G. (2014). Moving Forward the Discussion on Sudden Infant and Perinatal Unexplained Death. In: Crib Death - Sudden Infant Death Syndrome (SIDS). Springer, Cham. https://doi.org/10.1007/978-3-319-08347-6_4

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