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Reconstructive Options in Wound Care: From Simplest to Most Complex

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Pearls and Pitfalls in Skin Ulcer Management

Abstract

Despite significant advances, treatment for chronic ulcers remains challenging to clinicians and surgeons and, in addition, they demand many healthcare resources. Chronic wounds include diabetic foot, venous or arterial vascular leg, and pressure ulcers. Due to their complex etiology, they frequently require a multidisciplinary approach. It is critical to provide individualized patient assessment and treatment, preventing complications. Pressure ulcers are classified as grades I–IV depending on the extent and severity of the wound. Grades I and II are generally managed conservatively; instead, grades III and IV may need surgical procedures, from debridement to complex reconstruction. Simple surgical procedures such as direct closure and skin grafting are useful in early-stage ulcers. However, for advanced chronic pressure injuries, soft tissue flap coverage such as musculocutaneous, fasciocutaneous, and perforator-based flaps may be required. The selection of a proper reconstructive surgery depends on multiple factors, including ulcer location and grade, vascularization of adjacent tissues, patient mobility, and surgeon preference.

This chapter provides an overview of the management and reconstructive modalities of complex chronic ulcers in various anatomical locations, including atypical location of pressure ulcers during the COVID-19 pandemic. Hence, particular emphasis has been given to current advances in reconstructive surgical procedures to achieve healing in such patients.

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References

  1. Padula WV, Delarmente BA. The national cost of hospital-acquired pressure injuries in the United States. Int Wound J. 2019;16(3):634–40. https://doi.org/10.1111/iwj.13071.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Richmond NA, Maderal AD, Vivas AC. Evidence-based management of common chronic lower extremity ulcers. Dermatol Ther. 2013;26(3):187–96. https://doi.org/10.1111/dth.12051.

    Article  PubMed  Google Scholar 

  3. Rice JB, Desai U, Cummings AK, Birnbaum HG, Skornicki M, Parsons NB. Burden of diabetic foot ulcers for medicare and private insurers. Diabetes Care. 2014;37(3):651–8. https://doi.org/10.2337/dc13-2176.

    Article  PubMed  Google Scholar 

  4. Shankaran V, Brooks M, Mostow E. Advanced therapies for chronic wounds: NPWT, engineered skin, growth factors, extracellular matrices. Dermatol Ther. 2013;26(3):215–21. https://doi.org/10.1111/dth.12050.

    Article  PubMed  Google Scholar 

  5. Clarke HF, Bradley C, Whytock S, Handfield S, van der Wal R, Gundry S. Pressure ulcers: implementation of evidence-based nursing practice. J Adv Nurs. 2005;49(6):578–90. https://doi.org/10.1111/j.1365-2648.2004.03333.x.

    Article  PubMed  Google Scholar 

  6. Bennett G, Dealey C, Posnett J. The cost of pressure ulcers in the UK. Age Ageing. 2004;33(3):230–5. https://doi.org/10.1093/ageing/afh086.

    Article  PubMed  Google Scholar 

  7. Nunan R, Harding KG, Martin P. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech. 2014;7(11):1205–13. https://doi.org/10.1242/dmm.016782.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hsu KF, Kao LT, Chu PY, et al. Simple and efficient pressure ulcer reconstruction via primary closure combined with closed-incision negative pressure wound therapy (CiNPWT)-experience of a single surgeon. J Pers Med. 2022;12(2):182. https://doi.org/10.3390/jpm12020182.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Baccarani A, Pappalardo M, Starnoni M, De Santis G. Plastic surgeons in the middle of the coronavirus disease 2019 pandemic storm in Italy. Plast Reconstr Surg Glob Open. 2020;8(5):e2889. https://doi.org/10.1097/GOX.0000000000002889.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Starnoni M, Baccarani A, Pappalardo M, De Santis G. Management of personal protective equipment in plastic surgery in the era of coronavirus disease. Plast Reconstr Surg Glob Open. 2020;8(5):e2879. https://doi.org/10.1097/GOX.0000000000002879.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lindqvist EK, Sommar P, Stenius M, Lagergren JF. Complications after pressure ulcer surgery - a study of 118 operations in spinal cord injured patients. J Plast Surg Hand Surg. 2020;54(3):145–50. https://doi.org/10.1080/2000656X.2020.1720700.

    Article  PubMed  Google Scholar 

  12. Chiang IH, Wang CH, Tzeng YS. Surgical treatment and strategy in patients with multiple pressure sores. Int Wound J. 2018;15(6):900–8. https://doi.org/10.1111/iwj.12942.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Tchanque-Fossuo CN, Kuzon WM. An evidence-based approach to pressure sores. Plast Reconstr Surg. 2011;127(2):932–9. https://doi.org/10.1097/PRS.0b013e3182046a02.

    Article  CAS  PubMed  Google Scholar 

  14. Anon. Pressure ulcers in adults: prediction and prevention. Clinical practice guideline nAfHCP. Panel for the Prediction and Prevention of Pressure Ulcers in Adults. Dermatol Nurs. 1992;5(1):17–33.

    Google Scholar 

  15. Marriott R, Rubayi S. Successful truncated osteomyelitis treatment for chronic osteomyelitis secondary to pressure ulcers in spinal cord injury patients. Ann Plast Surg. 2008;61(4):425–9. https://doi.org/10.1097/SAP.0b013e318162f257.

    Article  CAS  PubMed  Google Scholar 

  16. Develop- NPSAPC, ment Conference Staging System FA. http://www.npuap.org/pr2.htm. Accessed 29 Nov 2009.

  17. Kruger EA, Pires M, Ngann Y, Sterling M, Rubayi S. Comprehensive management of pressure ulcers in spinal cord injury: current concepts and future trends. J Spinal Cord Med. 2013;36(6):572–85. https://doi.org/10.1179/2045772313Y.0000000093.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Singh R, Rohilla RK, Siwach R, Verma V, Kaur K. Surgery for pressure ulcers improves general health and quality of life in patients with spinal cord injury. J Spinal Cord Med. 2010;33(4):396–400. https://doi.org/10.1080/10790268.2010.11689718.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rubayi S, Burnett CC. The efficacy of single-stage surgical management of multiple pressure sores in spinal cord-injured patients. Ann Plast Surg. 1999;42(5):533–9. https://doi.org/10.1097/00000637-199905000-00012.

    Article  CAS  PubMed  Google Scholar 

  20. Dwivedi MK, Srivastava RN, Bhagat AK, et al. Pressure ulcer management in paraplegic patients with a novel negative pressure device: a randomised controlled trial. J Wound Care. 2016;25(4):199–200, 202–4, 206–7. https://doi.org/10.12968/jowc.2016.25.4.199.

    Article  CAS  PubMed  Google Scholar 

  21. Dumville JC, Webster J, Evans D, Land L. Negative pressure wound therapy for treating pressure ulcers. Cochrane Database Syst Rev. 2015;5:CD011334. https://doi.org/10.1002/14651858.CD011334.pub2.

    Article  Google Scholar 

  22. Gupta S, Baharestani M, Baranoski S, et al. Guidelines for managing pressure ulcers with negative pressure wound therapy. Adv Skin Wound Care. 2004;17(Suppl 2):1–16. https://doi.org/10.1097/00129334-200411002-00001.

    Article  PubMed  Google Scholar 

  23. Kirman CN et al Pressure ulcers ntapUoFCoM. 2008. www.emedicine.com/plastic/topic424.htm.

  24. Ichioka S, Ohura N, Nakatsuka T. Benefits of surgical reconstruction in pressure ulcers with a non-advancing edge and scar formation. J Wound Care. 2005;14(7):301–5. https://doi.org/10.12968/jowc.2005.14.7.26807.

    Article  CAS  PubMed  Google Scholar 

  25. Boyko TV, Longaker MT, Yang GP. Review of the current management of pressure ulcers. Adv Wound Care (New Rochelle). 2018;7(2):57–67. https://doi.org/10.1089/wound.2016.0697.

    Article  PubMed  Google Scholar 

  26. Schiffman J, Golinko MS, Yan A, Flattau A, Tomic-Canic M, Brem H. Operative debridement of pressure ulcers. World J Surg. 2009;33(7):1396–402. https://doi.org/10.1007/s00268-009-0024-4.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Rudensky B, Lipschits M, Isaacsohn M, Sonnenblick M. Infected pressure sores: comparison of methods for bacterial identification. South Med J. 1992;85(9):901–3.

    Article  CAS  PubMed  Google Scholar 

  28. Laing TA, Ekpete N, Oon S, Carroll SM. Surgical reconstruction of pressure ulcer defects: a single- or two-stage procedure? J Wound Ostomy Continence Nurs. 2010;37(6):615–8. https://doi.org/10.1097/WON.0b013e3181f90d03.

    Article  PubMed  Google Scholar 

  29. Sørensen JL, Jørgensen B, Gottrup F. Surgical treatment of pressure ulcers. Am J Surg. 2004;188(1A Suppl):42–51. https://doi.org/10.1016/S0002-9610(03)00290-3.

    Article  PubMed  Google Scholar 

  30. Boyce DE, Shokrollahi K. Reconstructive surgery. BMJ. 2006;332(7543):710–2. https://doi.org/10.1136/bmj.332.7543.710.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Kierney PC, Engrav LH, Isik FF, Esselman PC, Cardenas DD, Rand RP. Results of 268 pressure sores in 158 patients managed jointly by plastic surgery and rehabilitation medicine. Plast Reconstr Surg. 1998;102(3):765–72. https://doi.org/10.1097/00006534-199809030-00022.

    Article  CAS  PubMed  Google Scholar 

  32. Baccarani A, De Maria F, Pappalardo M, Pedone A, De Santis G. Necrobiosis Lipoidica Affecting the Leg: What Is the Best Treatment in a Patient with Very High Aesthetic Demand? Plast Reconstr Surg Glob Open. 2020;8(7):e3000. https://doi.org/10.1097/GOX.0000000000003000. eCollection 2020 Jul. PMID: 32802684

  33. Schryvers OI, Stranc MF, Nance PW. Surgical treatment of pressure ulcers: 20-year experience. Arch Phys Med Rehabil. 2000;81(12):1556–62. https://doi.org/10.1053/apmr.2000.17828.

    Article  CAS  PubMed  Google Scholar 

  34. Sameem M, Au M, Wood T, Farrokhyar F, Mahoney J. A systematic review of complication and recurrence rates of musculocutaneous, fasciocutaneous, and perforator-based flaps for treatment of pressure sores. Plast Reconstr Surg. 2012;130(1):67e–77e. https://doi.org/10.1097/PRS.0b013e318254b19f.

    Article  CAS  PubMed  Google Scholar 

  35. Homma K, Murakami G, Fujioka H, Fujita T, Imai A, Ezoe K. Treatment of ischial pressure ulcers with a posteromedial thigh fasciocutaneous flap. Plast Reconstr Surg. 2001;108(7):1990–6; discussion 1997. https://doi.org/10.1097/00006534-200112000-00023.

    Article  CAS  PubMed  Google Scholar 

  36. Janis JE, Kwon RK, Attinger CE. The new reconstructive ladder: modifications to the traditional model. Plast Reconstr Surg. 2011;127(Suppl 1):205S–12S. https://doi.org/10.1097/PRS.0b013e318201271c.

    Article  CAS  PubMed  Google Scholar 

  37. Levine SM, Sinno S, Levine JP, Saadeh PB. Current thoughts for the prevention and treatment of pressure ulcers: using the evidence to determine fact or fiction. Ann Surg. 2013;257(4):603–8. https://doi.org/10.1097/SLA.0b013e318285516a.

    Article  PubMed  Google Scholar 

  38. Borman H, Maral T. The gluteal fasciocutaneous rotation-advancement flap with V-Y closure in the management of sacral pressure sores. Plast Reconstr Surg. 2002;109(7):2325–9. https://doi.org/10.1097/00006534-200206000-00025.

    Article  PubMed  Google Scholar 

  39. Coşkunfirat OK, Ozgentaş HE. Gluteal perforator flaps for coverage of pressure sores at various locations. Plast Reconstr Surg. 2004;113(7):2012–7; discussion 2018-9. https://doi.org/10.1097/01.prs.0000122215.48226.3f.

    Article  PubMed  Google Scholar 

  40. Hong JPJ, Goh TLH, Choi DH, Kim JJ, Suh HS. The efficacy of perforator flaps in the treatment of chronic osteomyelitis. Plast Reconstr Surg. 2017;140(1):179–88. https://doi.org/10.1097/PRS.0000000000003460.

    Article  CAS  PubMed  Google Scholar 

  41. Suh HP, Hong JP. The role of reconstructive microsurgery in treating lower-extremity chronic wounds. Int Wound J. 2019;16(4):951–9. https://doi.org/10.1111/iwj.13127.

    Article  PubMed  PubMed Central  Google Scholar 

  42. He J, Xu H, Wang T, Ma S, Dong J. Treatment of complex ischial pressure sores with free partial lateral latissimus dorsi musculocutaneous flaps in paraplegic patients. J Plast Reconstr Aesthet Surg. 2012;65(5):634–9. https://doi.org/10.1016/j.bjps.2011.10.001.

    Article  PubMed  Google Scholar 

  43. Parkash S, Banerjee S. The total gluteus maximus rotation and other gluteus maximus musculocutaneous flaps in the treatment of pressure ulcers. Br J Plast Surg. 1986;39(1):66–71. https://doi.org/10.1016/0007-1226(86)90006-8.

    Article  CAS  PubMed  Google Scholar 

  44. Ohjimi H, Ogata K, Setsu Y, Haraga I. Modification of the gluteus maximus V-Y advancement flap for sacral ulcers: the gluteal fasciocutaneous flap method. Plast Reconstr Surg. 1996;98(7):1247–52. https://doi.org/10.1097/00006534-199612000-00020.

    Article  CAS  PubMed  Google Scholar 

  45. Park C, Park BY. Fasciocutaneous V-Y advancement flap for repair of sacral defects. Ann Plast Surg. 1988;21(1):23–6. https://doi.org/10.1097/00000637-198807000-00004.

    Article  CAS  PubMed  Google Scholar 

  46. Rubayi S, Doyle BS. The gluteus maximus muscle-splitting myocutaneous flap for treatment of sacral and coccygeal pressure ulcers. Plast Reconstr Surg. 1995;96(6):1366–71. https://doi.org/10.1097/00006534-199511000-00020.

    Article  CAS  PubMed  Google Scholar 

  47. Lin CT, Ou KW, Chiao HY, et al. Inferior gluteal artery perforator flap for sacral pressure ulcer reconstruction: a retrospective case study of 11 patients. Ostomy Wound Manage. 2016;62(1):34–9.

    PubMed  Google Scholar 

  48. Zhang N, Yu X, Zhao Q, et al. Rotational repair of pressure ulcer using double-perforators based flaps: a report of 11 cases. J Tissue Viability. 2016;25(4):244–8. https://doi.org/10.1016/j.jtv.2016.06.003.

    Article  PubMed  Google Scholar 

  49. Koshima I, Moriguchi T, Soeda S, Kawata S, Ohta S, Ikeda A. The gluteal perforator-based flap for repair of sacral pressure sores. Plast Reconstr Surg. 1993;91(4):678–83. https://doi.org/10.1097/00006534-199304000-00017.

    Article  CAS  PubMed  Google Scholar 

  50. Allen RJ, Tucker C. Superior gluteal artery perforator free flap for breast reconstruction. Plast Reconstr Surg. 1995;95(7):1207–12. https://doi.org/10.1097/00006534-199506000-00010.

    Article  CAS  PubMed  Google Scholar 

  51. Verpaele AM, Blondeel PN, Van Landuyt K, et al. The superior gluteal artery perforator flap: an additional tool in the treatment of sacral pressure sores. Br J Plast Surg. 1999;52(5):385–91. https://doi.org/10.1054/bjps.1999.3101.

    Article  CAS  PubMed  Google Scholar 

  52. Ao M, Mae O, Namba Y, Asagoe K. Perforator-based flap for coverage of lumbosacral defects. Plast Reconstr Surg. 1998;101(4):987–91. https://doi.org/10.1097/00006534-199804040-00015.

    Article  CAS  PubMed  Google Scholar 

  53. Wilhelmi BJNMP. Surgical treatment and principles. Carbondale, IL: Department of Surgery, Division of Plastic Surgery, Southern Illinois University School of Medicine, E-Medicine; 2008. www.emedicine.com/plastic/topic462.htm.

    Google Scholar 

  54. Marchi M, Battaglia S, Marchese S, Intagliata E, Spataro C, Vecchio R. Surgical reconstructive procedures for treatment of ischial, sacral and trochanteric pressure ulcers. G Chir. 2015;36(3):112–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Lee JT, Cheng LF, Lin CM, Wang CH, Huang CC, Chien SH. A new technique of transferring Island pedicled anterolateral thigh and vastus lateralis myocutaneous flaps for reconstruction of recurrent ischial pressure sores. J Plast Reconstr Aesthet Surg. 2007;60(9):1060–6. https://doi.org/10.1016/j.bjps.2007.03.026.

    Article  PubMed  Google Scholar 

  56. Mills R. Gluteus maximus musculocutaneous flap. In: Strauch B, Vasconez L, Hall-Findlay E, editors. Grabb’s encyclopedia of flaps, vol. 3. London: Little Brown; 1990. p. 1687–8.

    Google Scholar 

  57. Tobin GR, Sanders BP, Man D, Weiner LJ. The biceps femoris myocutaneous advancement flap: a useful modification for ischial pressure ulcer reconstruction. Ann Plast Surg. 1981;6(5):396–401. https://doi.org/10.1097/00000637-198105000-00009.

    Article  CAS  PubMed  Google Scholar 

  58. Labandter HP. The gracilis muscle flap and musculocutaneous flap in the repair of perineal and ischial defects. Br J Plast Surg. 1980;33(1):95–8. https://doi.org/10.1016/0007-1226(80)90064-8.

    Article  CAS  PubMed  Google Scholar 

  59. Rubayi S, Chandrasekhar BS. Trunk, abdomen, and pressure sore reconstruction. Plast Reconstr Surg. 2011;128(3):201e–15e. https://doi.org/10.1097/PRS.0b013e31822214c1.

    Article  CAS  PubMed  Google Scholar 

  60. Singh R, Wadhwani J, Rohilla RK, Kaur K. Proximal femoral resection and tensor fascia Lata flap for recalcitrant trochanteric pressure ulcers. Spinal Cord Ser Cases. 2019;5:15. https://doi.org/10.1038/s41394-019-0157-0.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Malik R, Pinto P, Bogaisky M, Ehrlich AR. Older adults with heel ulcers in the acute care setting: frequency of noninvasive vascular assessment, surgical intervention, and 1-year mortality. J Am Med Dir Assoc. 2013;14(12):916–9. https://doi.org/10.1016/j.jamda.2013.09.004.

    Article  PubMed  Google Scholar 

  62. Bosanquet DC, Wright AM, White RD, Williams IM. A review of the surgical management of heel pressure ulcers in the 21st century. Int Wound J. 2016;13(1):9–16. https://doi.org/10.1111/iwj.12416.

    Article  PubMed  Google Scholar 

  63. Park JS, Lee JH, Lee JS, Baek JH. Medialis pedis flap for reconstruction of weight bearing heel. Microsurgery. 2017;37(7):780–5. https://doi.org/10.1002/micr.30198.

    Article  PubMed  Google Scholar 

  64. Finkemeier CG, Neiman R. Reverse sural artery pedicle flap. J Orthop Trauma. 2016;30(Suppl 2):S41–2. https://doi.org/10.1097/BOT.0000000000000613.

    Article  PubMed  Google Scholar 

  65. Grishkevich VM. Proximally based sural adipose-cutaneous/scar flap in elimination of ulcerous scar soft-tissue defect over the achilles tendon and posterior heel region: a new approach. J Burn Care Res. 2014;35(3):e143–50. https://doi.org/10.1097/BCR.0b013e3182a2a74f.

    Article  PubMed  Google Scholar 

  66. Pappalardo M, Jeng SF, Sadigh PL, Shih HS. Versatility of the Free Anterolateral Thigh Flap in the Reconstruction of Large Defects of the Weight-Bearing Foot: A Single-Center Experience with 20 Consecutive Cases. J Reconstr Microsurg. 2016;32(7):562–70.

    Google Scholar 

  67. Rubayi S, Kiyono Y. Flap surgery to cover olecranon pressure ulcers in spinal cord injury patients. Plast Reconstr Surg. 2001;107(6):1473–81. https://doi.org/10.1097/00006534-200105000-00026.

    Article  CAS  PubMed  Google Scholar 

  68. Bunkis J, Ryu RK, Walton RL, Epstein LI, Vasconez LO. Fasciocutaneous flap coverage for periolecranon defects. Ann Plast Surg. 1985;14(4):361–70. https://doi.org/10.1097/00000637-198504000-00010.

    Article  CAS  PubMed  Google Scholar 

  69. Thornton JW, Stevenson TR, VanderKolk CA. Osteoradionecrosis of the olecranon: treatment by radial forearm flap. Plast Reconstr Surg. 1987;80(6):833–5. https://doi.org/10.1097/00006534-198712000-00015.

    Article  CAS  PubMed  Google Scholar 

  70. Kokkalis ZT, Papanikos E, Mazis GA, Panagopoulos A, Konofaos P. Lateral arm flap: indications and techniques. Eur J Orthop Surg Traumatol. 2019;29(2):279–84. https://doi.org/10.1007/s00590-019-02363-0.

    Article  PubMed  Google Scholar 

  71. Schmidt CC, Kohut GN, Greenberg JA, Kann SE, Idler RS, Kiefhaber TR. The anconeus muscle flap: its anatomy and clinical application. J Hand Surg Am. 1999;24(2):359–69. https://doi.org/10.1053/jhsu.1999.0359.

    Article  CAS  PubMed  Google Scholar 

  72. Lalikos JF, Fudem GM. Brachioradialis musculocutaneous flap closure of the elbow utilizing a distal skin Island: a case report. Ann Plast Surg. 1997;39(2):201–4. https://doi.org/10.1097/00000637-199708000-00017.

    Article  CAS  PubMed  Google Scholar 

  73. Ham W, Schoonhoven L, Schuurmans MJ, Leenen LP. Pressure ulcers from spinal immobilization in trauma patients: a systematic review. J Trauma Acute Care Surg. 2014;76(4):1131–41. https://doi.org/10.1097/TA.0000000000000153.

    Article  PubMed  Google Scholar 

  74. Davies KE, Yesudian P. Pressure alopecia. Int J Trichol. 2012;4(2):64–8. https://doi.org/10.4103/0974-7753.96901.

    Article  Google Scholar 

  75. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–13. https://doi.org/10.1016/S0140-6736(20)30211-7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Knight D. Patient positioning in anaesthesia. Continuing education in anaesthesia. Crit Care Pain. 2004;4(5):160–3.

    Google Scholar 

  77. Offner PJ, Haenel JB, Moore EE, Biffl WL, Franciose RJ, Burch JM. Complications of prone ventilation in patients with multisystem trauma with fulminant acute respiratory distress syndrome. J Trauma. 2000;48(2):224–8. https://doi.org/10.1097/00005373-200002000-00004.

    Article  CAS  PubMed  Google Scholar 

  78. Lucchini A, Bambi S, Mattiussi E, et al. Prone position in acute respiratory distress syndrome patients: a retrospective analysis of complications. Dimens Crit Care Nurs. 2020;39(1):39–46. https://doi.org/10.1097/DCC.0000000000000393.

    Article  PubMed  Google Scholar 

  79. Bloomfield R, Noble DW, Sudlow A. Prone position for acute respiratory failure in adults. Cochrane Database Syst Rev. 2015;11:CD008095. https://doi.org/10.1002/14651858.CD008095.pub2.

    Article  Google Scholar 

  80. Ibarra G, Rivera A, Fernandez-Ibarburu B, Lorca-García C, Garcia-Ruano A. Prone position pressure sores in the COVID-19 pandemic: the Madrid experience. J Plast Reconstr Aesthet Surg. 2020;74:2141. https://doi.org/10.1016/j.bjps.2020.12.057.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Pappalardo M, Starnoni M, De Maria F, et al. Secondary autologous fat grafting for the treatment of Chin necrosis as a consequence of prone position in COVID-19 patients. Plast Reconstr Surg Glob Open. 2022;10(11):e4705. https://doi.org/10.1097/GOX.0000000000004705.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Coleman SR, Lam S, Cohen SR, Bohluli B, Nahai F. Fat grafting: challenges and debates. Atlas Oral Maxillofac Surg Clin North Am. 2018;26(1):81–4. https://doi.org/10.1016/j.cxom.2017.10.006.

    Article  PubMed  Google Scholar 

  83. Pappalardo M, Davies K, Morley S. Fat Grafting in Facial Palsy: A Secondary Revision Technique to Improve the Facial Aesthetics. Plast Reconstr Surg Glob Open. 2022;10(10):e4572. https://doi.org/10.1097/GOX.0000000000004572. eCollection 2022 Oct. PMID: 36284721

  84. Pappalardo M, Montesano L, et al. Immunomodulation in vascularized composite allotransplantation: what is the role for adipose-derived stem cells? Ann Plast Surg. 2019;82(2):245–51. https://doi.org/10.1097/SAP.0000000000001763.

    Article  CAS  PubMed  Google Scholar 

  85. Di Stefano AB, Pappalardo M, et al. MicroRNAs in solid organ and vascularized composite allotransplantation: Potential biomarkers for diagnosis and therapeutic use. Transplant Rev (Orlando). 2020;34(4):100566. https://doi.org/10.1016/j.trre.2020.100566.

    Article  PubMed  Google Scholar 

  86. Starnoni M, Pappalardo M, Spinella A, et al. Systemic sclerosis cutaneous expression: management of skin fibrosis and digital ulcers. Ann Med Surg. 2021;71:102984.

    Article  Google Scholar 

  87. Thamm O, Koenen P, et al. Autologous fat grafting improves wound healing. Plast Reconstr Surg. 2012;130(2S):485.

    Article  Google Scholar 

  88. Rangaswamy M. Regenerative wound healing by open grafting of autologous fat and PRP-gel—a new concept and potential alternative to flaps. Plast Reconstr Surg Glob Open. 2021;9(1):e3349. https://doi.org/10.1097/GOX.0000000000003349.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Davalbhakta AV, Niranjan NS. Fasciocutaneous flaps based on fascial feeding vessels for defects in the periolecranon area. Br J Plast Surg 1999;52:60.

    Google Scholar 

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Pappalardo, M., Lolli, F., Lattanzi, M., De Santis, G. (2023). Reconstructive Options in Wound Care: From Simplest to Most Complex. In: Maruccia, M., Papa, G., Ricci, E., Giudice, G. (eds) Pearls and Pitfalls in Skin Ulcer Management. Springer, Cham. https://doi.org/10.1007/978-3-031-45453-0_39

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