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Catalase-Like Nanozymes and Their Applications in Alleviating Tumor Hypoxia for the Therapeutic Enhancement

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9th International Conference on the Development of Biomedical Engineering in Vietnam (BME 2022)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 95))

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Abstract

Cancer has been globally acknowledged as one of the most dangerous health problems. Although current therapies have shown promising results, they cannot eliminate all tumor cells and prevent the recurrence of these cells in the long term. The aggressive progress of a tumor can be triggered when the cancer is suffered from oxygen depletion or so-called hypoxia. Previously, researchers primarily utilized catalase's enzymatic activity to convert the endogenous hydrogen peroxide in cancer cells into oxygen, alleviating intracellular hypoxia. However, using natural enzymes has faced limitations, such as low stability and uneasy and costly production, making it hard to commercialize this method. To tackle the problem, synthetic nanomaterials, which could mimic enzyme-like activity, are utilized and named nanozyme. The ability of nanozymes mostly comes from the redox reaction of cations of high-Z metals, such as manganese, iron, cerium, and iridium. This review will offer readers an overview of the synergistic effect of nanozyme-based delivery models with the ability to generate oxygen to attenuate tumor hypoxia and enhance the therapeutic outcome. Based on the literature search, each type of nanozymes possesses both pros and cons; however, they all perform well in suppressing tumor hypoxia and improving therapeutic efficacy. Though, more studies must be conducted to guarantee these catalase-mimicking nanozymes’ long-term safety before the clinical application. Besides, solving the problem of hypoxia also opens up new paths for potential applications in 3D in-vitro cancer cell culture.

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Acknowledgments

This work was supported by International University (Grant no: T2020-01-BT).

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  1. School of Biotechnology, International University, Vietnam National University - Ho Chi Minh City (VNU - HCMC), 700000, Ho Chi Minh City, Vietnam

    Dinh Nam Nguyen & Kim Truc Nguyen

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  1. Dinh Nam Nguyen
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  1. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Van Toi Vo

  2. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Thi-Hiep Nguyen

  3. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Binh Long Vong

  4. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Ngoc Bich Le

  5. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Thanh Qua Nguyen

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Nguyen, D.N., Nguyen, K.T. (2024). Catalase-Like Nanozymes and Their Applications in Alleviating Tumor Hypoxia for the Therapeutic Enhancement. In: Vo, V.T., Nguyen, TH., Vong, B.L., Le, N.B., Nguyen, T.Q. (eds) 9th International Conference on the Development of Biomedical Engineering in Vietnam. BME 2022. IFMBE Proceedings, vol 95. Springer, Cham. https://doi.org/10.1007/978-3-031-44630-6_25

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