Abstract
Colorectal cancer is the third most commonly diagnosed cancer and second leading cause of cancer-related mortality globally [1, 2]. Based on adenoma-carcinoma sequence theory, early detection and removal of colorectal neoplasms is essential for improving cancer incidence and mortality [3]. Ideally, a neoplastic lesion should be resected in one-piece (en-bloc) with histologically negative margins (R0). Fortunately, 80–90% of polyps are ≤1 cm and can effectively be managed by conventional polypectomy [4]. However, management of large colorectal polyps (≥2 cm) require more advanced resection techniques, as conventional snare-based techniques might result in piecemeal resection, which precludes proper histopathological evaluation and increases the risk for recurrence [5]. Given that large polyps may have an increased risk for harboring malignancy [6], adequate treatment is of the utmost importance. Further, risks of different procedures should be considered.
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References
World Health Organization. Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Published February 2022. Accessed Dec 2022.
Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol. 2021;14(10):101174.
Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36(6):2251–70.
Ma MX, Bourke MJ. Complications of endoscopic polypectomy, endoscopic mucosal resection and endoscopic submucosal dissection in the colon. Best Pract Res Clin Gastroenterol. 2016;30(5):749–67.
Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, et al. Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2015;47(9):829–54.
He X, Wu K, Ogino S, Giovannucci EL, Chan AT, Song M. Association between risk factors for colorectal cancer and risk of serrated polyps and conventional adenomas. Gastroenterology. 2018;155(2):355–373.e18.
Gotoda T, Kondo H, Ono H, et al. A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc. 1999;50(4):560–3.
Hashiguchi Y, Muro K, Saito Y, et al. Japanese Society for Cancer of the colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020;25(1):1–42.
Oka S, Tanaka S, Saito Y, et al. Local recurrence after endoscopic resection for large colorectal neoplasia: a multicenter prospective study in Japan. Am J Gastroenterol. 2015;110(5):697–707.
Iizuka H, Okamura S, Onozato Y, Ishihara H, Kakizaki S, Mori M. Endoscopic submucosal dissection for colorectal tumors. Gastroenterol Clin Biol. 2009;33(10–11):1004–11.
Saito Y, Fukuzawa M, Matsuda T, et al. Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection. Surg Endosc. 2010;24(2):343–52.
Lee EJ, Lee JB, Lee SH, Youk EG. Endoscopic treatment of large colorectal tumors: comparison of endoscopic mucosal resection, endoscopic mucosal resection-precutting, and endoscopic submucosal dissection. Surg Endosc. 2012;26(8):2220–30.
Tajika M, Niwa Y, Bhatia V, et al. Comparison of endoscopic submucosal dissection and endoscopic mucosal resection for large colorectal tumors. Eur J Gastroenterol Hepatol. 2011;23(11):1042–9.
Soliman H, Brieau B, Guillaumot MA, et al. Invasive pit pattern, macronodule and depression are predictive factors of submucosal invasion in colorectal laterally spreading tumours from a Western population. United European Gastroenterol J. 2018;6(10):1569–77.
Ham NS, Kim J, Oh EH, et al. Cost of endoscopic submucosal dissection versus endoscopic piecemeal mucosal resection in the Colorectum. Dig Dis Sci. 2020;65(4):969–77.
Inoue T, Nakagawa K, Yamasaki Y, et al. Underwater endoscopic mucosal resection versus endoscopic submucosal dissection for 20-30 mm colorectal polyps. J Gastroenterol Hepatol. 2021;36(9):2549–57.
Byeon JS, Yang DH, Kim KJ, et al. Endoscopic submucosal dissection with or without snaring for colorectal neoplasms. Gastrointest Endosc. 2011;74(5):1075–83.
Bae JH, Yang DH, Lee S, et al. Optimized hybrid endoscopic submucosal dissection for colorectal tumors: a randomized controlled trial. Gastrointest Endosc. 2016;83(3):584–92.
Yang DH, Kwak MS, Park SH, et al. Endoscopic mucosal resection with circumferential mucosal incision for colorectal neoplasms: comparison with endoscopic submucosal dissection and between two Endoscopists with different experiences. Clin Endosc. 2017;50(4):379–87.
Gamaleldin M, Benlice C, Delaney CP, Steele S, Gorgun E. Management of the colorectal polyp referred for resection: a case-matched comparison of advanced endoscopic surgery and laparoscopic colectomy. Surgery. 2018;163(3):522–7.
Horiuchi A, Makino T, Kajiyama M, Tanaka N, Sano K, Graham DY. Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial. Endoscopy. 2016;48(7):646–51.
Yen AW, Leung JW, Wilson MD, Leung FW. Underwater versus conventional endoscopic resection of nondiminutive nonpedunculated colorectal lesions: a prospective randomized controlled trial (with video). Gastrointest Endosc. 2020 Mar;91(3):643–654.e2.
Chien HC, Uedo N, Hsieh PH. Comparison of underwater and conventional endoscopic mucosal resection for removing sessile colorectal polyps: a propensity-score matched cohort study. Endosc Int Open. 2019;7(11):E1528–36.
Patel M, Haque M, Kohli D, et al. Endoscopic resection reduces morbidity when compared to surgery in veterans with large and complex colorectal polyps. Surg Endosc. 2021;35(3):1164–70.
Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329(27):1977–81.
Lin JS, Perdue LA, Henrikson NB, Bean SI, Blasi PR. Screening for colorectal cancer: updated evidence report and systematic review for the US preventive services task force [published correction appears in JAMA. 2021 Jul 20;326(3):279]. JAMA. 2021;325(19):1978–98.
Zhang M, Shin EJ. Successful endoscopic strategies for difficult polypectomy. Curr Opin Gastroenterol. 2013;29(5):489–894.
Gorgun E, Benlice C, Church JM. Does cancer risk in colonic polyps unsuitable for polypectomy support the need for advanced endoscopic resections? J Am Coll Surg. 2016;223(3):478–84.
Vu JV, Sheetz KH, De Roo AC, Hiatt T, Hendren S. Variation in colectomy rates for benign polyp and colorectal cancer. Surg Endosc. 2021;35(2):802–8.
Ma C, Teriaky A, Sheh S, et al. Morbidity and mortality after surgery for nonmalignant colorectal polyps: a 10-year Nationwide analysis. Am J Gastroenterol. 2019;114(11):1802–10.
Shirai M, Nakamura T, Matsuura A, Ito Y, Kobayashi S. Safer colonoscopic polypectomy with local submucosal injection of hypertonic saline-epinephrine solution. Am J Gastroenterol. 1994;89(3):334–8.
Yamamoto H, Kawata H, Sunada K, et al. Successful en-bloc resection of large superficial tumors in the stomach and colon using sodium hyaluronate and small-caliber-tip transparent hood. Endoscopy. 2003;35(8):690–4.
Zhang XQ, Sang JZ, Xu L, et al. Endoscopic mucosal resection-precutting vs conventional endoscopic mucosal resection for sessile colorectal polyps sized 10-20 mm. World J Gastroenterol. 2022;28(45):6397–409.
Li D, Wang W, Xie J, et al. Efficacy and safety of three different endoscopic methods in treatment of 6-20 mm colorectal polyps. Scand J Gastroenterol. 2020;55(3):362–70.
Luigiano C, Consolo P, Scaffidi MG, et al. Endoscopic mucosal resection for large and giant sessile and flat colorectal polyps: a single-center experience with long-term follow-up. Endoscopy. 2009;41(10):829–35.
Mandic O, Jovanovic I, Cvetkovic M, et al. Factors predicting malignant occurrence and polyp recurrence after the endoscopic resection of large colorectal polyps: a single center experience. Medicina (Kaunas). 2022;58(10):1440.
Bujanda L, Cosme A, Gil I, Arenas-Mirave JI. Malignant colorectal polyps. World J Gastroenterol. 2010;16(25):3103–11.
Nett A, Binmoeller K. Underwater endoscopic mucosal resection. Gastrointest Endosc Clin N Am. 2019;29(4):659–73.
Choi AY, Moosvi Z, Shah S, et al. Underwater versus conventional EMR for colorectal polyps: systematic review and meta-analysis. Gastrointest Endosc. 2021;93(2):378–89.
Xu MD, Wang XY, Li QL, et al. Colorectal lateral spreading tumor subtypes: clinicopathology and outcome of endoscopic submucosal dissection. Int J Color Dis. 2013;28(1):63–72.
Draganov PV, Aihara H, Karasik MS, et al. Endoscopic submucosal dissection in North America: a large prospective multicenter study. Gastroenterology. 2021;160(7):2317–2327.e2.
Tanaka S, Oka S, Chayama K. Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection. J Gastroenterol. 2008;43(9):641–51.
Sakamoto T, Saito Y, Fukunaga S, Nakajima T, Matsuda T. Learning curve associated with colorectal endoscopic submucosal dissection for endoscopists experienced in gastric endoscopic submucosal dissection. Dis Colon Rectum. 2011;54(10):1307–12.
Rajendran A, Pannick S, Thomas-Gibson S, et al. Systematic literature review of learning curves for colorectal polyp resection techniques in lower gastrointestinal endoscopy. Color Dis. 2020;22(9):1085–100.
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Yilmaz, S., Gorgun, E. (2023). What Are the Options for Management of Large Colonic Polyps?. In: Umanskiy, K., Hyman, N. (eds) Difficult Decisions in Colorectal Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-031-42303-1_15
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DOI: https://doi.org/10.1007/978-3-031-42303-1_15
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