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T1ρ Mapping and Its Applications for Assessment of Renal Fibrosis

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Advanced Clinical MRI of the Kidney

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Abstract

In renal MRI, measurement of the spin-lattice relaxation time of water molecules in the rotating frame (T1ρ) may provide a valuable biomarker for kidney fibrosis. Due to the sensitivity of T1ρ to the interactions of free water molecules to macromolecules such as collagen, there is substantial interest in mapping T1ρ for noninvasive imaging of renal fibrosis, which is accompanied by collagen deposition. Unlike other MRI-based markers of tissue fibrosis, T1ρ is not affected by blood flow, perfusion, or inflammation, which enhances its attractiveness as a noninvasive and specific biomarker of kidney fibrosis. In this chapter, we will discuss the physical principles of T1ρ mapping, different pulse sequence implementations, data acquisition and analysis methods, followed by an overview of emerging applications of T1ρ imaging of kidney disease.

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Acknowledgement

We gratefully acknowledge the Preclinical PET Imaging Facility and Biomedical Magnetic Resonance Center at Washington University School of Medicine in St. Louis. This work was supported by National Institutes of Health (NIH) Grants R01DK110622, R01DK111861, R01DK129888, and R41DK129138. E. J. Baldelomar also received support by NIH Grant TL1TR002344.

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Authors and Affiliations

  1. Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Octavia Bane & Sara Lewis

  2. BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Octavia Bane

Authors
  1. Octavia Bane
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  2. Sara Lewis
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Correspondence to Octavia Bane .

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Editors and Affiliations

  1. Department of Radiology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Suraj D. Serai

  2. Department of Radiology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Kassa Darge

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Bane, O., Lewis, S. (2023). T1ρ Mapping and Its Applications for Assessment of Renal Fibrosis. In: Serai, S.D., Darge, K. (eds) Advanced Clinical MRI of the Kidney. Springer, Cham. https://doi.org/10.1007/978-3-031-40169-5_11

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  • DOI: https://doi.org/10.1007/978-3-031-40169-5_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-40168-8

  • Online ISBN: 978-3-031-40169-5

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