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Transcatheter Carotid Body Denervation: First-in-Man Results and Future Directions

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Renal Denervation

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Abstract

The carotid body (CB), a chemoreceptor located at the carotid bifurcation, is considered a therapeutic target in diseases mediated by the sympathetic nervous system. Surgical resection of the CB has demonstrated possible benefits in patients with resistant hypertension. Recent unpublished results from a proof of concept study indicate that transcatheter carotid body ablation is safe and effective and results in significant BP reduction, particularly in patients who have combined (systolic and diastolic phase) hypertension. Presently this technology is not being studied in prospective trials but appears promising as an approach to treat hypertension with evidence suggesting heightened BP lowering responses in patients with increased peripheral chemoreceptor activity. Notably, concerns regarding the use of this approach with respect to preservation of physiological breathing responses will entail further studies with rigorous short and long term safety evaluation.

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Abbreviations

BP:

Blood pressure

CB:

Carotid body

COPD:

Chronic obstructive pulmonary disease

DBP:

Diastolic blood pressure

ISH:

Isolated systolic hypertension

IVUS:

Intravascular ultrasound

SBP:

Systolic blood pressure

SHR:

Spontaneously hypertensive rat

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Declaration of Interest

Prof Lobo is a consultant to Medtronic, ReCor Medical, Ablative Solutions, Aktiia and Vascular Dynamics. He has received educational grants from Medtronic and ReCor Medical and speaker fees from CVRx.

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Authors and Affiliations

  1. Barts BP Centre of Excellence, Barts Heart Centre, St Bartholomew’s Hospital, West Smithfield, London, UK

    Melvin D. Lobo

  2. Barts NIHR Cardiovascular Biomedical Research Centre, Charterhouse Square, William Harvey Research Institute, Queen Mary University London, London, UK

    Melvin D. Lobo

Authors
  1. Melvin D. Lobo
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Correspondence to Melvin D. Lobo .

Editor information

Editors and Affiliations

  1. University of Arizona, Phoenix, AZ, USA

    Richard R. Heuser

  2. Dobeny Hypertension Centre, Royal Perth Hospital, University of Western Australia, Perth, WA, Australia

    Markus P. Schlaich

  3. Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland

    Dagmara Hering

  4. Cardio Vasculäres Centrum Frankfurt, Frankfurt, Germany

    Stefan C. Bertog

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Lobo, M.D. (2023). Transcatheter Carotid Body Denervation: First-in-Man Results and Future Directions. In: Heuser, R.R., Schlaich, M.P., Hering, D., Bertog, S.C. (eds) Renal Denervation. Springer, Cham. https://doi.org/10.1007/978-3-031-38934-4_19

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  • DOI: https://doi.org/10.1007/978-3-031-38934-4_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38933-7

  • Online ISBN: 978-3-031-38934-4

  • eBook Packages: MedicineMedicine (R0)

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